
Santa Isabel Vacations from $500
Book a Hotel + Flight or Car together to unlock savings
Your Santa Isabel Vacation
Say farewell to planning worries and hello to a Santa Isabel vacation package. With everything organized before you leave, you can focus on discovering every inch of this city, starting with Espino, which is great for hiking, nature and families. Make your trip to Santa Isabel even more fulfilling by including some sightseeing. Parque Ceremonial Indigena de Caguana, Parque Ceremonial Indigena Caguana and Parque Acuatico are among the popular attractions worth exploring. Expedia has what you need to escape the everyday. Tailor your vacation to Santa Isabel to match your travel style, whatever that may be!
The Latest Santa Isabel vacation packages


Ola Boutique Hotel
Reviewed on Aug 26, 2025

San Agustin Apartments
Reviewed on Aug 26, 2025

Urbana Hotel
Reviewed on Aug 26, 2025

The Oliver Hotel
Reviewed on Aug 25, 2025
Discover the most popular places to visit in Santa Isabel
Parque Ceremonial Indigena de Caguana
Explore the great outdoors at Parque Ceremonial Indigena de Caguana, a lovely green space in Caguana. Wander the forest or discover the area's countryside.
Parque Ceremonial Indigena Caguana
You can spend time browsing the exhibits at Parque Ceremonial Indigena Caguana in Caguana. Discover the area's countryside and waterfalls.
Batey Zipline Adventure
You can take time to visit Batey Zipline Adventure during your travels to Caguana. Wander the forest or discover the area's countryside.
What to do in Santa Isabel

Explore Indigenous Roots with Farm-to-Table Meal and Transport

Utuado Canyon, River & Waterfall Adventure in Puerto Rico

Private Tour of the White Canyon Ancestral Route in Utuado
Santa Isabel Hotel Deals

Costa Bahia Hotel & Convention Center
Reviewed on Aug 21, 2025

Hotel Nuevo Mejico
Reviewed on Aug 13, 2025

Parador El Buen Café
Reviewed on Aug 18, 2025