Southern Region Vacations & Trips

Book a Hotel + Flight or Car together to unlock savings

Photo by Kalunde Mbevi
  • Plan, book, travel with confidence

  • Better together

    Save up to $1,045 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Your Southern Region Vacation

When adventure calls, answer it with a tailor-made vacation package to Southern Region. Wherever it is you're headed and whatever you have planned, prepare to discover a destination that'll make you truly feel alive. Your trip to Southern Region wouldn't be complete without spending some time in its best cities, starting with Blantyre. A couple of the top attractions here include Mandala House and Carlsberg Brewery. Zomba is another favorite city with Southern Region travelers. Visitors to this city enjoy Emperor's View and Williams Falls. Expedia has everything you need when it comes to organizing your Southern Region vacation. From flights and hotels, to activities and more, we know how to create a travel experience like no other.

Top destinations in Southern Region

Find the Best Southern Region Vacation Packages

Southern Region Essential Information

Language
Chichewa
Currency
Malawian kwachas
Closest Airport
Chileka Intl. Airport (BLZ)
Top Sights
Lake Malawi National Park, Monkey Bay Beach and Liwonde National Park

Southern Region Hotel Deals

Protea Hotel by Marriott Blantyre Ryalls

Protea Hotel by Marriott Blantyre Ryalls

4.5 out of 5
2 Hannover Avenue Blantyre
Fully refundableReserve now, pay when you stay
$146 nightly
The price is $171 total per night from Dec 13 to Dec 14
$171 total
Dec 13 - Dec 14
Total with taxes and fees
8.8/10 Excellent! (141 reviews)
Lovely old hotel with lots of character. Staff are polite and helpful

Reviewed on Feb 14, 2025

Protea Hotel by Marriott Blantyre Ryalls
Crossroads Hotel Blantyre

Crossroads Hotel Blantyre

3.5 out of 5
Crossroads Mall Blantyre
$156 nightly
The price is $184 total per night from Nov 19 to Nov 20
$184 total
Nov 19 - Nov 20
Total with taxes and fees
8.8/10 Excellent! (46 reviews)
Nice breakfast buffet, helpful professional staff, clean, comfy, convenient , lots of food choices in attached mall

Reviewed on Oct 6, 2025

Crossroads Hotel Blantyre
Amaryllis Hotel

Amaryllis Hotel

5 out of 5
2 Laws Rd Blantyre Southern Region
Fully refundableReserve now, pay when you stay
$137 nightly
The price is $162 total per night from Nov 28 to Nov 29
$162 total
Nov 28 - Nov 29
Total with taxes and fees
10/10 Exceptional! (2 reviews)
If you're looking for modern conveniences like air conditioning, wifi, great service, and nice rooms, this is Blantyre's best hotel by far. The staff was incredible - it made me realize that Malawi can have a real five star tourism industry if it wants to. Mwai at the front desk is exceptional, as ...

Reviewed on Sep 16, 2025

Amaryllis Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Southern Region

What to do in Southern Region

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.