Title: The Best 5 Star Hotels in Opelousas, LA from $105 | Expedia.com

[Opelousas Travel Guide](https://expedia.com/Opelousas.dx9235)[Hotels in Opelousas](https://expedia.com/Opelousas-Hotels.d9235.Travel-Guide-Hotels)[Vacation Rentals in Opelousas](https://expedia.com/Opelousas-Vacation-Rentals.d9235.Travel-Guide-VacationRentals)[Flights to Opelousas](https://expedia.com/Cheap-Flights-To-Opelousas.d9235.Travel-Guide-Flights)[Car Rentals in Opelousas](https://expedia.com/Car-Rentals-In-Opelousas.d9235.Car-Rental-Guide)[Opelousas Vacation Packages](https://expedia.com/Opelousas.d9235.Destination-Travel-Guides)

![The historic Dutch Romanesque Revival style Cathedral of Saint John the Evangelist or La Cathedrale St-Jean built in 1916 on Cathedral Street in downtown Lafayette, Louisiana, USA](https://images.trvl-media.com/place/9235/0930b9c0-a21c-4193-a87e-9efe9ae4e660.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/9235/0930b9c0-a21c-4193-a87e-9efe9ae4e660.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check availability on Opelousas 5 Star Hotels

Tonight

[Mar 19 - Mar 20](https://www.expedia.com/Hotel-Search?regionId=9235&startDate=2026-03-19&endDate=2026-03-20&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Mar 20 - Mar 21](https://www.expedia.com/Hotel-Search?regionId=9235&startDate=2026-03-20&endDate=2026-03-21&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Mar 20 - Mar 22](https://www.expedia.com/Hotel-Search?regionId=9235&startDate=2026-03-20&endDate=2026-03-22&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

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## Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Opelousas.

![DoubleTree by Hilton Hotel Lafayette](https://images.trvl-media.com/lodging/1000000/10000/3800/3724/3eb25caa_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### DoubleTree by Hilton Hotel Lafayette

1521 W Pinhook Rd Lafayette LA

$91 nightly

$105 total

Apr 5 - Apr 6

Total with taxes and fees

8.4/10 Very Good! (1,000 reviews)

[](https://expedia.com/Lafayette-Hotels-DoubleTree-By-Hilton-Hotel-Lafayette.h3724.Hotel-Information)

![Maison D'Memoire Bed & Breakfast Cottages](https://images.trvl-media.com/lodging/20000000/19440000/19439500/19439467/d6d4049a_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Maison D'Memoire Bed & Breakfast Cottages

8450 Roberts Cove Road Rayne LA

$179 nightly

$203 total

Mar 30 - Mar 31

Total with taxes and fees

9.6/10 Exceptional! (95 reviews)

[](https://expedia.com/Lafayette-Hotels-Maison-DMemoire-Bed-Breakfast-Cottages.h19439467.Hotel-Information)

![Wyndham Garden Lafayette](https://images.trvl-media.com/lodging/1000000/30000/27100/27016/92389f54_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Wyndham Garden Lafayette

1801 W Pinhook Road Lafayette LA

[Get rates](https://expedia.com/Hotel-Search?startDate=4%2F2%2F2026&endDate=4%2F3%2F2026&selected=27016&PinnedHotelID=27016&HadPinnedHotel=true&regionId=9235)

5.4/10 (548 reviews)

[](https://expedia.com/Lafayette-Hotels-Wyndham-Garden-Lafayette.h27016.Hotel-Information)

Still don't see what you're looking for?

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Learn more about Opelousas

Spice up your visit to the Zydeco Capital with live music venues and the annual Zydeco Festival in late August. Explore Cajun food history at the Opelousas Museum, then sample authentic boudin and crawfish at family-owned restaurants locals recommend.

[See all hotels in Opelousas](https://www.expedia.com/Hotel-Search?startDate=2026-04-02&endDate=2026-04-03&adults=2&regionId=9235)

![The historic Dutch Romanesque Revival style Cathedral of Saint John the Evangelist or La Cathedrale St-Jean built in 1916 on Cathedral Street in downtown Lafayette, Louisiana, USA](https://images.trvl-media.com/place/9235/0930b9c0-a21c-4193-a87e-9efe9ae4e660.jpg?impolicy=fcrop&w=900&h=600&p=1&q=high)

## Top Opelousas Hotel Reviews

## Find out more about Opelousas

You enjoy the finer things in life, both at home and on vacation. Why not demand the best during your excursion to Opelousas? There's no reason to delay a getaway to Opelousas any longer. You'll join the multitudes of vacationers who have made Opelousas so fashionable in the last year. The hotels in Opelousas also offer great customer service, averaging 3.6 in our ranking system, giving you a lot to look forward to. You deserve an outstanding getaway. Our 5-star hotels in Opelousas are the perfect places to relax in during your next chunk of time off.

### Book the Best Opelousas 5-Star Hotels

You can expect high quality from your hotel. Top-notch service, delicious meals, and one-on-one attention are all ready for you. You're sure to find exactly the accommodation you need. You'll be pleased to note that the hotels in Opelousas offer great customer service, averaging 3.6 in our ranking system, giving you a lot to look forward to. What creature comforts do you want in your lodging? 24-hour room service, so you can order that berry tart in the wee hours of the morning? A body scrub that will leave you feeling great? Butler services? Whatever it is your heart desires, you're bound to find it here. Want to see for yourself? Plenty of visitors recommend this location. 

But you aren't going to spend your entire vacation in your room, of course. You're in luck. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what's on your agenda, the 5-star hotels in Opelousas are waiting for you to relax after an exciting day.

### Make Your Escape

The results are in, and Opelousas 5-star hotels are the place to be when you book your next vacation. Many visitors recommend a trip to this location, so don't wait any longer. Expedia can help you land a great deal on accommodation. Your great getaway is just a mouse-click away. Choose one of the 5-star hotels in Opelousas today and decompress in total tranquility tomorrow.

## Frequently asked questions

### How much does it cost to stay in a 5-star hotel in Opelousas?

> - Search for the lowest price per night from $105

### What makes a hotel 5 stars in Opelousas?

### Are there any 5-star all-inclusive resorts in Opelousas?

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