A calm river with several colorful boats docked along the shore. In the background, there are buildings and a mosque.

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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in St. Louis.
Hotel La Residence

Hotel La Residence

BP 254 - 159 rue Blaise Diagne St. Louis
$108 nightly
$124 total
Sep 21 - Sep 22
Total with taxes and fees
Hotel La Residence
Hôtel de la Poste

Hôtel de la Poste

Quai Roume St. Louis Saint-Louis Region
$83 nightly
$97 total
Sep 26 - Sep 27
Total with taxes and fees
7.6/10 Good! (110 reviews)
Hôtel de la Poste
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Learn more about St. Louis

Wander the UNESCO-listed island with its colorful colonial buildings and visit the historic Faidherbe Bridge for spectacular river views. Explore the bustling Guet Ndar fishing quarter where you can watch fishermen bring in their daily catch and visit the North's oldest mosque.

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A calm river with several colorful boats docked along the shore. In the background, there are buildings and a mosque.
Photo by Samantha B.

Top St. Louis Hotel Reviews

Find out more about St. Louis

Pamper your every desire on your upcoming sabbatical. After all, you love the finer things in life, both at home and when you book a getaway. You'll join the multitudes of vacationers who have made St. Louis so popular in the last year. There's no reason to delay a getaway to St. Louis any longer. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Book one of Expedia's luxurious 5-star hotels in St. Louis and get ready to be pampered like never before. You deserve an outstanding getaway.

Book the Best St. Louis 5-Star Hotels

You'll have a wonderful time at one of these 5-star hotels. Exceptional customer care, luxurious bedding, and fabulous spa offerings are all on offer. You're sure to find exactly the accommodation you need. You'll also enjoy a high standard of care and meticulous guest relations, so get ready for a wonderful adventure. What kind of amenities will make your stay a wonderful one? A rejuvenating facial treatment to help your cares fall away? A concierge to help you make reservations at that outstanding restaurant? Comfortable beds, delectable chocolate desserts, and even a hot tub in the bathroom...these hotels are one-of-a-kind. Don't want to take our word for it? Explore our listings and pick the perfect accommodation for your needs.

Can't wait to get outside? We hear you. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. Whatever you plan to do, the 5-star hotels in St. Louis are the perfect place to rest up after an exciting day.

Your Getaway Starts Today

The results are in, and St. Louis 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. It's time to indulge yourself -- Expedia can help you land a great deal on accommodation. Opt for one of our St. Louis 5-star hotels today and relax in total tranquility at your convenience.

Frequently asked questions

How much does it cost to stay in a 5-star hotel in St. Louis?
There are a range of pricing options for 5-star hotels in St. Louis on Expedia. How much you'll pay will depend on your vacation dates, trip length and other factors. Compare available accommodations for your desired dates and use our pricing and other filters to land the ideal upscale stay.
  • Search for the lowest price per night from $97
What makes a hotel 5 stars in St. Louis?
Exceptional guest service characterizes every 5-star hotel in St. Louis. From the moment you arrive, staff attend to your every whim, whether arranging customized tours or providing a nightly turn-down service. Plus, hotels must feature superior conveniences to be entitled to a 5-star rating. These can include luxury bathrooms, a wellness center, pools, gastronomic kitchens and knowledgeable concierge.
Are there any 5-star all-inclusive resorts in St. Louis?
Use our convenient filters to find an upscale escape in St. Louis where everything you need is included. After your initial search, narrow your results for accommodations that have a 5-star rating and are deemed "All inclusive." The main thing to look forward to at these stays? Pure enjoyment and indulgence.

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