Title: The Best 5 Star Hotels in Syracuse, NE  | Expedia.com

[Syracuse Travel Guide](https://expedia.com/Syracuse.dx602465)[Hotels in Syracuse](https://expedia.com/Syracuse-Hotels.d602465.Travel-Guide-Hotels)[Vacation Rentals in Syracuse](https://expedia.com/Syracuse-Vacation-Rentals.d602465.Travel-Guide-VacationRentals)[Flights to Syracuse](https://expedia.com/Cheap-Flights-To-Syracuse.d602465.Travel-Guide-Flights)[Car Rentals in Syracuse](https://expedia.com/Car-Rentals-In-Syracuse.d602465.Car-Rental-Guide)[Syracuse Vacation Packages](https://expedia.com/Syracuse.d602465.Destination-Travel-Guides)

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## Check availability on Syracuse 5 Star Hotels

Tonight

[Feb 27 - Feb 28](https://www.expedia.com/Hotel-Search?regionId=602465&startDate=2026-02-27&endDate=2026-02-28&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Feb 28 - Mar 1](https://www.expedia.com/Hotel-Search?regionId=602465&startDate=2026-02-28&endDate=2026-03-01&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Feb 27 - Mar 1](https://www.expedia.com/Hotel-Search?regionId=602465&startDate=2026-02-27&endDate=2026-03-01&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Mar 6 - Mar 8](https://www.expedia.com/Hotel-Search?regionId=602465&startDate=2026-03-06&endDate=2026-03-08&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

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## Top Syracuse Hotel Reviews

## Find out more about Syracuse

Why not demand the best of accommodations during your holiday to Syracuse? After all, you love the finer things in life, both at home and when you book a getaway. You'll join the multitudes of vacationers who have made Syracuse so popular in the last year. There's no reason to delay a getaway to Syracuse any longer. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Book one of Expedia's luxurious 5-star hotels in Syracuse and get ready to enjoy the getaway of a lifetime. Don't wait any longer!

### 5-Star Hotels in Syracuse

A stay in one of these hotels is bound to be memorable. Spa treatments, delicious meals, and personalized service are all ready for you. You're sure to find exactly the accommodation you need. You can also look forward to an outstanding experience and fantastic customer care, so get ready for a wonderful adventure. How do you want to relax? A full-body massage to help your cares fall away? A concierge to help you pick out your next adventure? Comfortable beds, lip-smacking main courses, and even space for your family pet in some cases...these hotels have it all. 

But you aren't going to spend your entire vacation in your room, of course. We've got you covered. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what's on your agenda, the 5-star hotels in Syracuse are the perfect place to relax after a busy day. Ready to learn more? Then check out our listings and pick the perfect accommodation for your needs. 

### Your Getaway Starts Today

The results are in, and Syracuse 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. It's time to indulge yourself -- Expedia can help you land a great deal on accommodation. Opt for one of Expedia's Syracuse 5-star hotels today and settle down in complete comfort tomorrow.

## Frequently asked questions

### How much does it cost to stay in a 5-star hotel in Syracuse?

> - Search for the lowest price per night

### What makes a hotel 5 stars in Syracuse?

### Are there any 5-star all-inclusive resorts in Syracuse?

## Explore a world of travel with Expedia

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- [Unadilla Hotels ](https://www.expedia.com/Unadilla-Hotels.d553248634983496924.Travel-Guide-Hotels)
- [Otoe Hotels ](https://www.expedia.com/Otoe-Hotels.d553248634983071246.Travel-Guide-Hotels)
- [Palmyra Hotels ](https://www.expedia.com/Palmyra-Hotels.d553248634983378707.Travel-Guide-Hotels)
- [Hotels near The Golf Club at Table Creek ](https://www.expedia.com/The-Golf-Club-At-Table-Creek-Hotels.0-l553248621532648719-0.Travel-Guide-Filter-Hotels)
- [4 Star Hotels in Southeast Nebraska ](https://www.expedia.com/4Star-Southeast-Nebraska-Hotels.s40-0-d6230714.Travel-Guide-Filter-Hotels)
- [3 Star Hotels in Weeping Water ](https://www.expedia.com/3Star-Weeping-Water-Hotels.s30-0-d3000349812.Travel-Guide-Filter-Hotels)
- [Southeast Nebraska Hotels ](https://www.expedia.com/Southeast-Nebraska-Hotels.d6230714.Travel-Guide-Hotels)
- [B&B in Southeast Nebraska ](https://www.expedia.com/Southeast-Nebraska-Bed-And-Breakfast.d6230714-aaBedAndBreakfast.Travel-Guide-Accommodation)
- [Cheap Hotels in Southeast Nebraska ](https://www.expedia.com/Southeast-Nebraska-Hotels-Cheap-Hotels.0-0-d6230714-tCheapHotels.Travel-Guide-Filter-Hotels)
- [Luxury Hotels in Southeast Nebraska ](https://www.expedia.com/Southeast-Nebraska-Hotels-Luxury-Hotel.0-0-d6230714-tLuxuryHotel.Travel-Guide-Filter-Hotels)
- [Cottages in Southeast Nebraska ](https://www.expedia.com/Southeast-Nebraska-Cottages.d6230714-aaCottages.Travel-Guide-Accommodation)
- [Historic Hotels in Southeast Nebraska ](https://www.expedia.com/Southeast-Nebraska-Hotels-Historic-Hotel.0-0-d6230714-tHistoricHotel.Travel-Guide-Filter-Hotels)
- [Hotels with Kitchenettes in Southeast Nebraska ](https://www.expedia.com/Southeast-Nebraska-Hotels-Hotels-With-Kitchens.0-0-d6230714-tHotelswithKitchens.Travel-Guide-Filter-Hotels)
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- [Hotels & Resorts for Couples in Southeast Nebraska ](https://www.expedia.com/Southeast-Nebraska-Hotels-Couples-Resorts-Hotels.0-0-d6230714-tCouplesResortsHotels.Travel-Guide-Filter-Hotels)
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- [Weeping Water Hotels ](https://www.expedia.com/Weeping-Water-Hotels.d3000349812.Travel-Guide-Hotels)
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- [Hotels near Wildwood Golf Course ](https://www.expedia.com/Wildwood-Golf-Course-Hotels.0-l6311901-0.Travel-Guide-Filter-Hotels)
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- [3 Star Hotels in Nebraska City ](https://www.expedia.com/3Star-Nebraska-City-Hotels.s30-0-d8901.Travel-Guide-Filter-Hotels)
- [4 Star Hotels in Nebraska City ](https://www.expedia.com/4Star-Nebraska-City-Hotels.s40-0-d8901.Travel-Guide-Filter-Hotels)
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- [Romantic Hotels in Nebraska City ](https://www.expedia.com/Nebraska-City-Hotels-Romantic-Hotel.0-0-d8901-tRomanticHotel.Travel-Guide-Filter-Hotels)
- [Extended Stay Hotels in Nebraska City ](https://www.expedia.com/Nebraska-City-Hotels-Extended-Stay-Hotels.0-0-d8901-tExtendedStayHotels.Travel-Guide-Filter-Hotels)
- [Waterpark Hotels in Nebraska City ](https://www.expedia.com/Nebraska-City-Hotels-Waterpark-Hotels.0-0-d8901-tWaterparkHotels.Travel-Guide-Filter-Hotels)
- [Family Hotels in Nebraska City ](https://www.expedia.com/Nebraska-City-Hotels-Family-Hotel.0-0-d8901-tFamilyHotel.Travel-Guide-Filter-Hotels)
- [Boutique Hotels in Nebraska City ](https://www.expedia.com/Nebraska-City-Hotels-Boutique-Hotel.0-0-d8901-tBoutiqueHotel.Travel-Guide-Filter-Hotels)
- [Hotels with an Indoor Pool in Nebraska City ](https://www.expedia.com/Nebraska-City-Hotels-Hotels-With-Indoor-Pool.0-0-d8901-tHotelswithIndoorPool.Travel-Guide-Filter-Hotels)
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- [Green Hotels in Nebraska City ](https://www.expedia.com/Nebraska-City-Hotels-GreenSustainable.0-0-d8901-tGreenSustainable.Travel-Guide-Filter-Hotels)
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- [Hotels with Balconies in Nebraska City ](https://www.expedia.com/Nebraska-City-Hotels-Hotels-With-Balconies.0-0-d8901-tHotelswithBalconies.Travel-Guide-Filter-Hotels)

- [Flights from Otoe County ](https://www.expedia.com/lp/flights/553248635976433235/flights-from-otoe-county)
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- [Flights to Nebraska City ](https://www.expedia.com/Cheap-Flights-To-Nebraska-City.d8901.Travel-Guide-Flights)
- [Flights from Nebraska City ](https://www.expedia.com/lp/flights/8901/flights-from-nebraska-city)

- [Visit Southeast Nebraska ](https://www.expedia.com/Southeast-Nebraska.dx6230714)
- [Southeast Nebraska Vacations ](https://www.expedia.com/Southeast-Nebraska.d6230714.Destination-Travel-Guides)
- [Visit Weeping Water ](https://www.expedia.com/Weeping-Water.dx3000349812)
- [Eagle Raceway ](https://www.expedia.com/Eagle-Raceway-Eagle.d655702016888266752.Vacation-Attraction)
- [Visit Nehawka ](https://www.expedia.com/Nehawka.dx3000349780)
- [Arbor Day Farm ](https://www.expedia.com/Arbor-Day-Farm-Nebraska-City.d553248621532648722.Vacation-Attraction)
- [Wildwood Golf Course ](https://www.expedia.com/Wildwood-Golf-Course-Nebraska-City.d6311901.Vacation-Attraction)
- [Grandpa's Woods Golf Course ](https://www.expedia.com/Grandpas-Woods-Golf-Course-Murdock.d553248621578434786.Vacation-Attraction)
- [Wildwood Historic Center ](https://www.expedia.com/Wildwood-Historic-Center-Nebraska-City.d6311905.Vacation-Attraction)
- [Arbor Lodge State Historical Park ](https://www.expedia.com/Arbor-Lodge-State-Historical-Park-Nebraska-City.d6311895.Vacation-Attraction)
- [Visit Nebraska City ](https://www.expedia.com/Nebraska-City.dx8901)
- [Nebraska City Vacations ](https://www.expedia.com/Nebraska-City.d8901.Destination-Travel-Guides)

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- [Car rentals near Burr ](https://www.expedia.com/Car-Rentals-In-Burr.d553248634983243042.Car-Rental-Guide)
- [Car rentals near Weeping Water ](https://www.expedia.com/Car-Rentals-In-Weeping-Water.d3000349812.Car-Rental-Guide)
- [Car rentals near Nehawka ](https://www.expedia.com/Car-Rentals-In-Nehawka.d3000349780.Car-Rental-Guide)
- [Car rentals near Nebraska City ](https://www.expedia.com/Car-Rentals-In-Nebraska-City.d8901.Car-Rental-Guide)
- [Car rentals in Thrifty Car Rental 7135 Gilespie Street ](https://www.expedia.com/Thrifty-Car-Rental-at-7135-Gilespie-Street-Las-Vegas-Nevada-USA.v8901.Car-Rental-Guide-Location)
- [Enterprise Rental Cars in Nebraska City ](https://www.expedia.com/Enterprise-Car-Rentals-In-Nebraska-City.d8901-c15.Car-Rental-Guide-Suppliers)
- [Hertz Rental Cars in Nebraska City ](https://www.expedia.com/Hertz-Car-Rentals-In-Nebraska-City.d8901-c40.Car-Rental-Guide-Suppliers)
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- [Auto Rent Rental Cars in Nebraska City ](https://www.expedia.com/Auto-Rent-Car-Rentals-In-Nebraska-City.d8901-c1006.Car-Rental-Guide-Suppliers)
- [Payless Rental Cars in Nebraska City ](https://www.expedia.com/Payless-Car-Rentals-In-Nebraska-City.d8901-c38.Car-Rental-Guide-Suppliers)
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- [National Car Rental Rental Cars in Nebraska City ](https://www.expedia.com/National-Car-Rental-Car-Rentals-In-Nebraska-City.d8901-c42.Car-Rental-Guide-Suppliers)

- [Southeast Nebraska Vacation Rentals ](https://www.expedia.com/Southeast-Nebraska-Vacation-Rentals.d6230714.Travel-Guide-VacationRentals)
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- [Things to do in Southeast Nebraska ](https://www.expedia.com/Things-To-Do-In-Southeast-Nebraska.d6230714.Travel-Guide-Activities)