Title: $141 Cheap Flights to Santiago Island - Expedia.com ![One of the highlights of my trip to the Galapagos was snorkeling with Galapagos penguins off of Bartolome Island. Galapagos Penguins are the only penguin bread found north of the equator. #lifeatexpedia](https://images.trvl-media.com/place/6336382/a64f32d4-e200-431c-89af-7a17c4de4f0e.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Sarah Mack ![](https://images.trvl-media.com/place/6336382/a64f32d4-e200-431c-89af-7a17c4de4f0e.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # $141 Cheap Flights to Santiago Island [View $141 flight on Tue, Jun 16, 2026](https://expedia.com/Flights-Search?trip=oneway&leg1=from:CUE,to:GPS,departure:6/16/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:140.73&airProductToken=AQoxCi8IzIIBEgQxNDA0GIIlIOaTASiW7o8DMOrvjwM4T0AAWAFqAlFQcghPMDBRUEFaQhIKCAEQARgBKgJMQRgBIgQIARABKAIoBCgGMAE) [Santiago Island Travel Guide](https://expedia.com/Santiago-Island.dx6336381)[Hotels in Santiago Island](https://expedia.com/Santiago-Island-Hotels.d6336381.Travel-Guide-Hotels)[Car Rentals in Santiago Island](https://expedia.com/Car-Rentals-In-Santiago-Island.d6336381.Car-Rental-Guide)[Santiago Island Vacation Packages](https://expedia.com/Santiago-Island.d6336381.Destination-Travel-Guides) ## Popular airlines - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AV.svg) Avianca - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_LA.svg) LATAM Airlines Group - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__notification.svg) ### Be in the know Get alerts if flight prices drop or rise\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Book smarter Save up to 30% on select hotels after you book a flight\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Earn twice Earn your airline miles on top of our OneKeyCash [Learn about One Key](https://www.expedia.com/welcome-one-key) ## How much is the cheapest flight to Santiago Island? Prices were available within the past 7 days and start at $141 for one-way flights and $313 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply. All deals One way Roundtrip ![LATAM Airlines Group](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/LA.gif) Tue, Jun 16 - Sat, Jun 20 CUE Cuenca GPS Santa Cruz Island $313 Roundtrip found 6 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:CUE,to:GPS,departure:6/16/2026TANYT&leg2=from:GPS,to:CUE,departure:6/20/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:312.79&airProductToken=AQoxCi8IzIIBEgQxNDA0GIIlIOaTASiW7o8DMOrvjwM4T0AAWAFqAlFQcghPMDBRUEFaQgoxCi8IzIIBEgQxNDA5GOaTASCCJSijnZADMJOekAM4T0AAWAFqAlFQcghPMDBRUEFaQhIKCAEQARgBKgJMQRgBIgQIARABKAIoBCgGMAE) ![avianca](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/av.gif) Thu, Nov 5 - Thu, Nov 12 GYE Guayaquil GPS Santa Cruz Island $327 Roundtrip found 6 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:GYE,to:GPS,departure:11/5/2026TANYT&leg2=from:GPS,to:GYE,departure:11/12/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:326.19&airProductToken=AQo0CjIIwawBEgQxNjM4GIYmIOaTASjmrZwDMOOunAM4U0AAWAFqBUJBU0lDcghTUk9CMElSSQo0CjIIwawBEgQxNjM5GOaTASCGJijw_ZwDMOP-nAM4U0AAWAFqBUJBU0lDcghTUk9CMElSSRIKCAEQARgBKgJBVhgBIgQIARABKAIoAygEMAE) ![United](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/UA.gif) Thu, Apr 16 - Wed, Apr 22 EWR New York GPS Santa Cruz Island $888 Roundtrip found 5 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:EWR,to:GPS,departure:4/16/2026TANYT&leg2=from:GPS,to:EWR,departure:4/22/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:887.69&airProductToken=AQqhAQo0CNWCARIEMjY5MBjEjQEgiDgow8KKAzC1xIoDOFNAAFgBagdFQ09OT01ZcghTTkEzQTBFTgozCNWCARIEMTAwMhiIOCCUcijuxIoDMKnHigM4U0ABWAFqB0VDT05PTVlyCFNOQTNBMEVOCjQIwawBEgQxNjg4GJRyIOaTASjwyooDMPLLigM4UEABWAFqB0VDT05PTVlyCFNOQTNBMEVOCqEBCjQIwawBEgQxNjg5GOaTASCUcii5hosDMLuHiwM4U0AAWAFqB0VDT05PTVlyCEtOQTBBMEVOCjMI1YIBEgQyMDgzGJRyIIg4KK-LiwMw6o2LAzhLQAFYAWoHRUNPTk9NWXIIS05BMEEwRU4KNAjVggESBDEzOTcYiDggxI0BKL6RiwMwnpOLAzhLQAFYAWoHRUNPTk9NWXIIS05BMEEwRU4SCggBEAEYASoCVUEYASIECAEQASgCKAMoBDAB) ![Alaska Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AS.gif) Mon, Apr 27 - Wed, May 13 SEA Seattle GPS Santa Cruz Island $946 Roundtrip found 1 day ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:SEA,to:GPS,departure:4/27/2026TANYT&leg2=from:GPS,to:SEA,departure:5/13/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:945.63&airProductToken=AQqaAQotCMGmARIDMzA1GJIBIIwCKN-8iwMw0L-LAzhRQABYAWoCTUFyCFFIMkVDVU1OCjMIwawBEgQ3Mzc3GIwCIIYmKNnDiwMw7MWLAzhVQAFYAWoHQ0xBU1NJQ3IIVVpPQjJJUjkKNAjBrAESBDE2MzIYhiYg5pMBKP_HiwMw8siLAzhVQAFYAWoHQ0xBU1NJQ3IIVVpPQjJJUjkKmgEKNAjBrAESBDE2MzMY5pMBIIYmKIDyjAMw8_KMAzhVQABYAWoHQ0xBU1NJQ3IIVVpPQjJJUjkKMwjBrAESBDczNzgYhiYgjAIo8fSMAzD_9owDOFVAAVgBagdDTEFTU0lDcghVWk9CMklSOQotCMGmARIDMzA1GIwCIJIBKKj_jAMwwYKNAzhRQAFYAWoCTUFyCFFIMkVDVU1OEgoIARABGAEqAkFWGAEiBAgBEAEoAigDKAQwAQ) ![Delta](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/DL.gif) Tue, Jan 12 - Tue, Jan 26 MSP Minneapolis GPS Santa Cruz Island $1,241 Roundtrip found 4 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:MSP,to:GPS,departure:1/12/2027TANYT&leg2=from:GPS,to:MSP,departure:1/26/2027TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:1240.66&airProductToken=AQqRAQouCMSYARIENTA1MxjMfCCpUSjzrqIDMJ-wogM4VkAAWAFqAlNMcghOTFhTTERHWAouCMyCARIEMTQ1MxipUSCGJijysKIDMIe0ogM4TkABWAFqAlNMcghOTFhTTERHWAovCMyCARIEMTQxMRiGJiDmkwEol7WiAzCNtqIDOE5AAVgBagJTTHIITkxYU0xER1gKkQEKLwjMggESBDE0MTQY5pMBIIYmKNjHowMwxsijAzhOQABYAWoCU0xyCE5MWFNMREdYCi4IzIIBEgQxNDU0GIYmIKlRKMjKowMw2M2jAzhOQAFYAWoCU0xyCE5MWFNMREdYCi4IxJgBEgQ1MDAxGKlRIMx8KL3RowMwgtOjAzhWQAFYAWoCU0xyCE5MWFNMREdYEgwIARABGAEqAkxBMgAYASIECAEQASgCKAQoBjAB) ## Frequently asked questions ### What month is the cheapest to fly to Santiago Island? ### Which US cities fly direct to Santiago Island? ### How to find a cheap flight to Santiago Island? ### How to get a cheap last-minute flight to Santiago Island? ### How far in advance should I book a flight to Santiago Island? ### Which day of the week is the cheapest day to buy a plane ticket to Santiago Island? ### Which airlines fly to Santiago Island? ### Where do you fly into Santiago Island? ### How far is the airport from central Santiago Island? ### Can I save money by booking a Santiago Island trip package? ### Can I change or cancel my flight to Santiago Island? \*Flight schedules are subject to change. ## Book with confidence # Tips to find the cheapest flights to Santiago Island **The cheapest day to fly** Get started finding a cheap flight to Santiago Island on Expedia by either choosing a deal on this page or entering into the search bar your travel dates, origin airport, and whether you want roundtrip or one-way airfare. You can filter for flexibility, number of stops, airline, and departure/arrival times to find the best flight for you. **The cheapest month to fly** June is the cheapest month to fly to Santiago Island. This coincides with the low season when fewer people travel. Whichever month you travel in, though, be sure to book at least a month in advance if you want to score cheap tickets to Santiago Island. ARC's data shows that domestic flights booked 28 days or more before departure are typically 24% cheaper than those booked last minute. **The most affordable time to book a flight** Typically, a Sunday can be the cheapest time to book a flight to Santiago Island, according to ARC’s data. On average, you could save between 6% and 13% by booking on a Sunday instead of a Friday, which is the most expensive day to make a reservation. **The cheapest round-trip tickets to Santiago Island** The lowest price for round-trip flights to Santiago Island in 2026 starts from from $313, while one-way tickets start from from $141\. Expedia's effective search tool is one of the best ways to find a budget airfare. Simply enter your dates, and within seconds, it'll show you a vast selection of the cheapest flights to Santiago Island. If you have a preferred departure time or airline, you can use the handy filters to customize your search. **The cheapest airlines flying to Santiago Island** LATAM Airlines Group, avianca, United, Alaska Airlines, Delta are just some of the airlines that can typically offer cheap tickets to Santiago Island. You can find their most affordable flights by using the “airline” search filter and then sorting prices from low to high. As a trusted partner of the world's leading airlines, Expedia offers you some of the best airfare deals to Santiago Island and countless more destinations worldwide. **The most affordable airports to fly into** To view the cheapest airports to fly into for Santiago Island, simply order your search results from lowest to highest price. Expedia's search tool compares flight prices for all airports close to your destination, so you don't have to manually search them one by one to find the cheapest flight to Santiago Island. If you have a preferred place to fly into, take advantage of the “arrival airport” filter to narrow down your search on Expedia. **Save with a package** With Expedia's amazing [package deals](https://www.expedia.com/package-deals), you could save hundreds of dollars by booking your Santiago Island plane tickets together with your accommodations, car rental, or activities. Just select the search wizard's “package” option to view some of the cheapest deals. Look out for the green savings label to see how much you're saving. **Date flexibility for the cheapest flights to Santiago Island** If you can be flexible with your travel dates, it's a good idea to broaden your search by comparing prices on different days. This will open up more options, meaning you could uncover a less expensive flight to Santiago Island. **Stopover savings** The cheapest tickets to Santiago Island are sometimes those with a stopover. Book one of these flights, and you'll change planes at an airport en route to Santiago Island. While the overall travel time might be longer than a non-stop flight, you may decide it's worth it for the money saved. **Get Expedia's Price Drop Protection** Price Drop Protection means that if your flight gets cheaper after booking, you'll be credited the difference\*. This gives you peace of mind that you're getting one of the cheapest flights to Santiago Island for your chosen departure. Expedia's Price Drop Protection is available for a small fee but is free to One Key Gold and Platinum tier members. \*Terms apply. **Use our Price Tracking feature** Expedia's Price Tracking feature is another great tool that removes the guesswork from finding cheap flights to Santiago Island. Simply download the free Expedia app to your smart device and activate Santiago Island flight price alerts for your travel dates. There's even a price predictor tool that uses historical data to indicate the best time to book, giving you peace of mind that you'll nab the lowest prices. **Book with Expedia** As well as Price Drop Protection and Price Tracking, Expedia's close partnership with a vast selection of the world's leading airlines means you're sure to find cheap flights to Santiago Island. Plus, the One Key rewards program lets you earn real cash rewards on most bookings that you can use to save money on future trips. Best of all, it's free to join, and members often unlock exclusive discounts, too. Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023\. The percentages you see are averages. ## Travel information | Destination airport | Seymour | | ----------------------------- | ----------- | | Destination airport IATA code | GPS | | Destination city name | Isla Baltra | | Roundtrip price | $313 | ## Trending flights to Santiago Island Prices were available within the past 7 days and start at $141 for one-way flights and $313 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply. All deals One way Roundtrip ![avianca](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/av.gif) Thu, May 7 - Thu, May 14 MIA Miami GPS Santa Cruz Island $444 Roundtrip found 6 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:MIA,to:GPS,departure:5/7/2026TANYT&leg2=from:GPS,to:MIA,departure:5/14/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:443.26&airProductToken=AQpnCjEIwawBEgQ3Mzc3GIwCIIYmKPmojAMwjKuMAzhVQABYAWoFTElHSFRyCFVaT0IxSVI5CjIIwawBEgQxNjM4GIYmIOaTASiwrowDMKOvjAM4VUABWAFqBUxJR0hUcghVWk9CMUlSOQpnCjIIwawBEgQxNjM5GOaTASCGJiiw_owDMKP_jAM4VUAAWAFqBUxJR0hUcghVWk9CMUlSOQoxCMGsARIENzM4MBiGJiCMAiilgI0DMK6CjQM4VUABWAFqBUxJR0hUcghVWk9CMUlSORIKCAEQARgBKgJBVhgBIgQIARABKAIoAygEMAE) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - [Rabida Island Hotels ](https://www.expedia.com/Rabida-Island-Hotels.d6336653.Travel-Guide-Hotels) - 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