Title: $67 Cheap Flights & Airfare to Santo Domingo de los Tsáchilas - Expedia.com ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_flights_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_flights_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Cheap Flights to Santo Domingo de los Tsáchilas from $67 [View $67 flight on Fri, Feb 20, 2026](https://expedia.com/Flights-Search?trip=oneway&leg1=from:GYE,to:UIO,departure:2/20/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:66.96&airProductToken=AQozCjEIwawBEgQxNjc3GIYmIJRyKKvXhQMw4teFAzhTQABYAWoFQkFTSUNyCFNST0IwSVJJEgoIARABGAEqAkFWGAEiBAgBEAEoAigDKAQwAQ) - [Roundtrip](?flightType=roundtrip) - [One-way](?flightType=oneway) - [Multi-city](?flightType=multicity) ### Travelers Adults ChildrenAges 2 to 17 InfantsYounger than 2 EconomyPremium economyBusiness classFirst class Leaving from Going to Departing Returning Add a place to stay Add a car Direct flights only [Santo Domingo de los Tsáchilas Hotels](https://expedia.com/Destinations-In-Santo-Domingo-De-Los-Tsachilas.d6239845.Hotel-Destinations)[Vacation Rentals in Santo Domingo de los Tsáchilas](https://expedia.com/Destinations-In-Santo-Domingo-De-Los-Tsachilas.d6239845.Vacation-Rental-Destinations)[Car Rentals in Santo Domingo de los Tsáchilas](https://expedia.com/Destinations-In-Santo-Domingo-De-Los-Tsachilas.d6239845.Car-Rental-Destinations)[Santo Domingo de los Tsáchilas Vacations](https://expedia.com/Santo-Domingo-De-Los-Tsachilas.d6239845.Destination-Travel-Guides) ## Popular airlines to Santo Domingo de los Tsáchilas - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_LA.svg) LATAM Airlines Group - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AV.svg) Avianca - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AA.svg) American Airlines - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_DL.svg) Delta - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_UA.svg) United - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_CM.svg) Copa - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AC.svg) Air Canada - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__notification.svg) ### Be in the know Get alerts if flight prices drop or rise\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Book smarter Save up to 30% on select hotels after you book a flight\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Earn twice Earn your airline miles on top of our OneKeyCash [Learn about One Key](https://www.expedia.com/welcome-one-key) ## How much is the cheapest flight to Santo Domingo de los Tsáchilas? Prices were available within the past 7 days and start at $67 for one-way flights and $136 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply. All deals One way Roundtrip ![avianca](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/av.gif) Wed, Apr 8 - Wed, Apr 15 GYE Guayaquil UIO Quito $136 Roundtrip just found [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:GYE,to:UIO,departure:4/8/2026TANYT&leg2=from:UIO,to:GYE,departure:4/15/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:135.27&airProductToken=AQoiCiAIwawBEgQxNjE1GIYmIJRyKOXoiQMwnOmJAzhTQABYAQoiCiAIwawBEgQxNjE0GJRyIIYmKIy2igMww7aKAzhTQABYARIKCAEQARgBKgJBVhgBIgQIARABKAQwAQ) ![LATAM Airlines Group](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/LA.gif) Sat, Apr 11 - Sun, Apr 12 GYE Guayaquil UIO Quito $137 Roundtrip just found [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:GYE,to:UIO,departure:4/11/2026TANYT&leg2=from:UIO,to:GYE,departure:4/12/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:136.42&airProductToken=AQowCi4IzIIBEgQxNDA3GIYmIJRyKNKHigMwhYiKAzhPQABYAWoCUVByCE8wMFFQQVpKEgoIARABGAEqAkxBGAEiBAgBEAEoAigEKAYwAQ) ![LATAM Airlines Group](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/LA.gif) Wed, Apr 8 - Mon, Apr 20 GYE Guayaquil UIO Quito $138 Roundtrip just found [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:GYE,to:UIO,departure:4/8/2026TANYT&leg2=from:UIO,to:GYE,departure:4/20/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:137.57&airProductToken=AQoiCiAIzIIBEgQxNDE4GIYmIJRyKO3oiQMwoOmJAzhPQABYAQoiCiAIzIIBEgQxMzU0GJRyIIYmKOLsigMwl-2KAzhPQABYARIKCAEQARgBKgJMQRgBIgQIARABKAQwAQ) ![avianca](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/av.gif) Wed, Feb 11 - Sun, Feb 15 GYE Guayaquil UIO Quito $139 Roundtrip just found [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:GYE,to:UIO,departure:2/11/2026TANYT&leg2=from:UIO,to:GYE,departure:2/15/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:138.72&airProductToken=AQoiCiAIwawBEgQxNjE1GIYmIJRyKOXyhAMwnPOEAzhaQABYAQoiCiAIwawBEgQxNjEwGJRyIIYmKOeghQMwnqGFAzhXQABYARIKCAEQARgBKgJBVhgBIgQIARABKAQwAQ) ![LATAM Airlines Group](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/LA.gif) Thu, Feb 12 - Fri, Feb 13 GYE Guayaquil UIO Quito $142 Roundtrip just found [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:GYE,to:UIO,departure:2/12/2026TANYT&leg2=from:UIO,to:GYE,departure:2/13/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:141.02&airProductToken=AQoiCiAIzIIBEgQxMzYyGIYmIJRyKNf6hAMwiPuEAzhRQABYAQoiCiAIzIIBEgQxNDExGJRyIIYmKIuGhQMwwIaFAzhPQABYARIKCAEQARgBKgJMQRgBIgQIARABKAQwAQ) ![avianca](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/av.gif) Mon, Feb 9 - Wed, Feb 11 GYE Guayaquil UIO Quito $143 Roundtrip just found [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:GYE,to:UIO,departure:2/9/2026TANYT&leg2=from:UIO,to:GYE,departure:2/11/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:142.17&airProductToken=AQoiCiAIwawBEgQxNjIxGIYmIJRyKI3ahAMwxNqEAzhQQABYAQoiCiAIwawBEgQxNjc0GJRyIIYmKMnzhAMwgPSEAzhaQABYARIKCAEQARgBKgJBVhgBIgQIARABKAQwAQ) ![Copa](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/CM.gif) Mon, Mar 16 - Wed, Mar 25 BOS Boston UIO Quito $306 Roundtrip found 1 hour ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:BOS,to:UIO,departure:3/16/2026TANYT&leg2=from:UIO,to:BOS,departure:3/25/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:305.80&airProductToken=AQpjCjAIw5oBEgM3MDUYwZMBIO_EASjV5ocDMKXphwM4QUAAWAFqA0JBU3IIQUxBQVRaMlMKLwjDmgESAzIxMRjvxAEglHIok-qHAzCL64cDOEFAAFgBagNCQVNyCEFMQUFUWjJTCmMKLwjDmgESAzE1OBiUciDvxAEoxc2IAzC4zogDOEFAAFgBagNCQVNyCEFMQUFUWjJTCjAIw5oBEgM3MDQY78QBIMGTASj204gDMMLWiAM4QUAAWAFqA0JBU3IIQUxBQVRaMlMSCggCEAEYASoCQ00YASIECAEQASgCKAMoBDAL) ![United](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/UA.gif) Wed, Apr 29 - Mon, May 4 LAX Los Angeles UIO Quito $319 Roundtrip just found [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:LAX,to:UIO,departure:4/29/2026TANYT&leg2=from:UIO,to:LAX,departure:5/4/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:319.00&airProductToken=AQpxCjcI1YIBEgQyMDg2GIu4ASCIOCiV1YsDMNrWiwM4R0AAWAFqCjFfYmFzaWNlY29yCEdOQTBBMEJMCjYI1YIBEgQxMDAyGIg4IJRyKI7XiwMwydmLAzhHQABYAWoKMV9iYXNpY2Vjb3IIR05BMEEwQkwKcQo2CNWCARIEMTAwNRiUciCIOCipiowDMOSMjAM4R0AAWAFqCjFfYmFzaWNlY29yCEdOQTBBMEJMCjcI1YIBEgQxNzQzGIg4IIu4ASjLjowDMKaQjAM4R0AAWAFqCjFfYmFzaWNlY29yCEdOQTBBMEJMEgoIARABGAEqAlVBGAEiBAgBEAEoAigDKAQwCw) ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Tue, Mar 3 - Sun, Mar 8 MCO Orlando UIO Quito $332 Roundtrip found 7 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:MCO,to:UIO,departure:3/3/2026TANYT&leg2=from:UIO,to:MCO,departure:3/8/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:331.10&airProductToken=AQpmCjEIwYIBEgQyNTg3GMxwIIwCKNHShgMwntOGAzhCQABYAWoFQkFTSUNyCE9MTjBBSEJaCjEIwYIBEgQyMjU5GIwCIJRyKJLWhgMwj9iGAzhCQAFYAWoFQkFTSUNyCE9MTjBBSEJaCmUKMAjBggESAzkzMhiUciCMAijSiIcDMNqKhwM4QkAAWAFqBUJBU0lDcghPTE4wQUhCWgoxCMGCARIEMzI1MRiMAiDMcCjmjocDMLiPhwM4QkABWAFqBUJBU0lDcghPTE4wQUhCWhIMCAEQARgBKgJBQTIAGAEiBAgBEAEoAigDKAQwCw) ![United](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/UA.gif) Wed, Feb 25 - Fri, Mar 6 BWI Baltimore UIO Quito $334 Roundtrip found 2 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:BWI,to:UIO,departure:2/25/2026TANYT&leg2=from:UIO,to:BWI,departure:3/6/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:333.30&airProductToken=AQpECiAI1YIBEgQyMTQwGMFFIIg4KOGPhgMwu5GGAzhHQABYAQogCNWCARIEMTAwMhiIOCCUcijqkoYDMKqVhgM4R0ABWAEKQwogCNWCARIEMjA4MxiUciCIOCjr74YDMKbyhgM4R0AAWAEKHwjVggESAzYwNBiIOCDBRSiK84YDML70hgM4R0ABWAESCggBEAEYASoCVUEYASIECAEQASgEMAE) ## Airports in Santo Domingo de los Tsáchilas Prices were available within the past 7 days. Prices and availability are subject to change. [](https://www.expedia.com/Flights-Search?leg1=from:CMH,to:UIO,departure:2/20/2026TANYT&leg2=from:UIO,to:CMH,departure:2/28/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&sortOrder=INCREASING&sortType=PRICE) UIO Mariscal Sucre Intl. Cheapest [Flights from $945 ](https://www.expedia.com/Flights-Search?leg1=from:CMH,to:UIO,departure:2/20/2026TANYT&leg2=from:UIO,to:CMH,departure:2/28/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&sortOrder=INCREASING&sortType=PRICE) **Enjoy extra legroom, flight flexibility, and a seamless travel experience.** \*Flight schedules are subject to change. \*Flight schedules are subject to change. - Top Flights Destinations - Top Santo Domingo de los Tsáchilas Hotels - Airlines Operating - Expedia's Latest Trends ### Top Flight Destinations In Santo Domingo de los Tsáchilas - [Flights to Santo Domingo de los Colorados ](https://expedia.com/Cheap-Flights-To-Santo-Domingo-De-Los-Colorados.d6326188.Travel-Guide-Flights) - [Flights to San Miguel de los Bancos ](https://expedia.com/Cheap-Flights-To-San-Miguel-De-Los-Bancos.d6326183.Travel-Guide-Flights) - [Flights to Puerto Quito ](https://expedia.com/Cheap-Flights-To-Puerto-Quito.d553248635975102806.Travel-Guide-Flights) - [Flights to La Palma ](https://expedia.com/Cheap-Flights-To-La-Palma.d553248635975871253.Travel-Guide-Flights) - [Flights to Sigchos ](https://expedia.com/Cheap-Flights-To-Sigchos.d6351071.Travel-Guide-Flights) - [Flights to Lloa ](https://expedia.com/Cheap-Flights-To-Lloa.d553248635975867643.Travel-Guide-Flights) - [Flights to La Concordia ](https://expedia.com/Cheap-Flights-To-La-Concordia.d3000458248.Travel-Guide-Flights) - [Flights to Sierra ](https://expedia.com/Cheap-Flights-To-Sierra.d3000655750.Travel-Guide-Flights) - [Flights to Andes ](https://expedia.com/Cheap-Flights-To-Andes.d6053668.Travel-Guide-Flights) ### Top Flight Destinations In the World - [Flights to Australia ](https://expedia.com/Destinations-In-Australia.d10.Flight-Destinations) - [Flights to Brazil ](https://expedia.com/Destinations-In-Brazil.d23.Flight-Destinations) - [Flights to Mexico ](https://expedia.com/Destinations-In-Mexico.d117.Flight-Destinations) - [Flights to United States of America ](https://expedia.com/Destinations-In-United-States-Of-America.d201.Flight-Destinations) - [Flights to Canada ](https://expedia.com/Destinations-In-Canada.d31.Flight-Destinations) - [Flights to Colombia ](https://expedia.com/Destinations-In-Colombia.d38.Flight-Destinations) - [Flights to Russia ](https://expedia.com/Destinations-In-Russia.d153.Flight-Destinations) - [Flights to South Korea ](https://expedia.com/Destinations-In-South-Korea.d94.Flight-Destinations) - [Flights to Japan ](https://expedia.com/Destinations-In-Japan.d89.Flight-Destinations) - [Flights to United Kingdom ](https://expedia.com/Destinations-In-United-Kingdom.d190.Flight-Destinations) - [Flights to Türkiye ](https://expedia.com/Destinations-In-Turkiye.d183.Flight-Destinations) - [Flights to Argentina ](https://expedia.com/Destinations-In-Argentina.d8.Flight-Destinations) - [Flights to Greece ](https://expedia.com/Destinations-In-Greece.d67.Flight-Destinations) - [Flights to China ](https://expedia.com/Destinations-In-China.d37.Flight-Destinations) - [Flights to Italy ](https://expedia.com/Destinations-In-Italy.d86.Flight-Destinations) - [Flights to Spain ](https://expedia.com/Destinations-In-Spain.d166.Flight-Destinations) - [Flights to Indonesia ](https://expedia.com/Destinations-In-Indonesia.d81.Flight-Destinations) - [Flights to Switzerland ](https://expedia.com/Destinations-In-Switzerland.d174.Flight-Destinations) - [Flights to India ](https://expedia.com/Destinations-In-India.d80.Flight-Destinations) - [Flights to France ](https://expedia.com/Destinations-In-France.d59.Flight-Destinations) ### Top Santo Domingo de los Tsáchilas Hotels - [Hilton Colon Quito ](https://expedia.com/Quito-Hotels-Hilton-Colon-Quito.h687.Hotel-Information) - [Hotel San Francisco de Quito ](https://expedia.com/Quito-Hotels-Hotel-San-Francisco-De-Quito.h4460935.Hotel-Information) - [Hotel Plaza Grande ](https://expedia.com/Quito-Hotels-Hotel-Plaza-Grande.h1639958.Hotel-Information) - [Hotel Casa Alquimia ](https://expedia.com/Quito-Hotels-Hotel-Casa-Alquimia.h30630202.Hotel-Information) - [Hotel Reina Isabel ](https://expedia.com/Quito-Hotels-Hotel-Reina-Isabel.h4289762.Hotel-Information) - [Vista del Angel Hotel Boutique ](https://expedia.com/Quito-Hotels-Vista-Del-Angel-Hotel-Boutique.h23228412.Hotel-Information) - [Casa Gangotena ](https://expedia.com/Quito-Hotels-Casa-Gangotena.h6793417.Hotel-Information) - [Fenix Hotel ](https://expedia.com/Quito-Hotels-FENIX-HOTEL.h1277747.Hotel-Information) - [Hotel La Basílica Quito ](https://expedia.com/Quito-Hotels-Hotel-La-Basilica-Quito.h32904420.Hotel-Information) - [La Casona de la Ronda Boutique Hotel ](https://expedia.com/Quito-Hotels-La-Casona-De-La-Ronda-Hotel-Boutique-Luxury-Apartments.h5020816.Hotel-Information) - [Carlota Sustainable Design Hotel ](https://expedia.com/Quito-Hotels-Carlota-Sustainable-Design-Hotel.h15135784.Hotel-Information) - [Casa Joaquin Boutique Hotel ](https://expedia.com/Quito-Hotels-Casa-Joaquin-Boutique-Hotel.h6244831.Hotel-Information) - [ArtPlaza ](https://expedia.com/Quito-Hotels-ArtPlaza.h16005444.Hotel-Information) - [Mashpi Lodge ](https://expedia.com/Mashpi-Hotels-Mashpi-Lodge.h7597491.Hotel-Information) - [Friends Hotel & Rooftop - Historic Center & Museums ](https://expedia.com/Quito-Hotels-Friends-Hotel-Rooftop.h15046242.Hotel-Information) - [Mercure Alameda Quito ](https://expedia.com/Quito-Hotels-Mercure-Alameda-Quito.h11687.Hotel-Information) - [Hotel Mama Cuchara by Art Hotels Ecuador ](https://expedia.com/Quito-Hotels-Hotel-Mama-Cuchara.h21541564.Hotel-Information) - [Hotel Plaza del Teatro ](https://expedia.com/Quito-Hotels-Hotel-Plaza-Del-Teatro.h27846741.Hotel-Information) - [Hotel Patio Andaluz ](https://expedia.com/Quito-Hotels-Hotel-Patio-Andaluz.h1231706.Hotel-Information) - [Saint Thomas ](https://expedia.com/Quito-Hotels-Saint-Thomas.h18315528.Hotel-Information) ### Airlines Operating - [Amber Air ](https://expedia.com/Amber-Air-Flights.c0A.Travel-Guide-Airlines) - [BlueAir ](https://expedia.com/BlueAir-Flights.c0B.Travel-Guide-Airlines) - [Catovair ](https://expedia.com/Cobra-Aviation-Flights.c0C.Travel-Guide-Airlines) - [Darwin Airline SA Lugano ](https://expedia.com/Darwin-Airline-SA-Lugano-Flights.c0D.Travel-Guide-Airlines) - [Evergreen International ](https://expedia.com/Evergreen-International-Flights.c0E.Travel-Guide-Airlines) - [Ghadames Air Transport ](https://expedia.com/Ghadames-Air-Transport-Flights.c0G.Travel-Guide-Airlines) - [Aircompany Kokshetau ](https://expedia.com/AirCompany-Kokshetau-Flights.c0K.Travel-Guide-Airlines) - [Palau Asia ](https://expedia.com/Palau-Asia-Flights.c0P.Travel-Guide-Airlines) - [Royal Airways Limited ](https://expedia.com/Royal-Airways-Limited-Flights.c0S.Travel-Guide-Airlines) - [Vietnam Air Service Co. ](https://expedia.com/Vietnam-Air-Service-Co-Flights.c0V.Travel-Guide-Airlines) ### Expedia's Latest Trends Hotels - [Resorts & Hotels with Spas in Pastaza](https://expedia.com/Destinations-In-Pastaza-Spa-Hotel.0-0-d6239600-tSpaHotel.Hotel-Filter-Destinations) - [All-inclusive Resorts in Galápagos](https://expedia.com/Destinations-In-Galapagos-All-Inclusive-Hotel.0-0-d1371-tAllinclusiveHotel.Hotel-Filter-Destinations) - [Resorts & Hotels with Spas in Galápagos](https://expedia.com/Destinations-In-Galapagos-Spa-Hotel.0-0-d1371-tSpaHotel.Hotel-Filter-Destinations) - 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[Cruises to Galápagos](https://expedia.com/Cruises-to-Galapagos.d1371.Travel-Guide-Cruise) Activities - [Things to do in Santa Elena](https://expedia.com/Things-To-Do-In-Santa-Elena.d6239740.Travel-Guide-Activities) - [Things to do in Guayas](https://expedia.com/Things-To-Do-In-Guayas.d6239779.Travel-Guide-Activities) - [Things to do in Galápagos](https://expedia.com/Things-To-Do-In-Galapagos.d1371.Travel-Guide-Activities) Packages - [Galápagos Packages](https://expedia.com/Galapagos.d1371.Destination-Travel-Guides) - [Galápagos All Inclusive Vacation Packages](https://expedia.com/lp/theme-vacations/honeymoon-vacations/1371/Galapagos) - [Galápagos All Inclusive Vacation Packages](https://expedia.com/lp/theme-vacations/luxury-vacations/1371/Galapagos) - [Galápagos All Inclusive Vacation Packages](https://expedia.com/lp/theme-vacations/all-inclusive-vacations/1371/Galapagos) - [Napo Packages](https://expedia.com/Napo.d6239598.Destination-Travel-Guides) Vacation Rentals - [Galápagos Vacation Rental](https://expedia.com/Destinations-In-Galapagos.d1371.Vacation-Rental-Destinations) - [Loja Province Vacation Rental](https://expedia.com/Destinations-In-Loja-Province.d6239629.Vacation-Rental-Destinations) General - [Visit Cañar](https://expedia.com/Canar.dx6239670) - [Visit Pichincha](https://expedia.com/Pichincha.dx6239720) - [Visit Esmeraldas](https://expedia.com/Esmeraldas.dx6239725) - [Visit Guayas](https://expedia.com/Guayas.dx6239779) - [Visit Manabí](https://expedia.com/Manabi.dx6239728) - [Visit Galápagos](https://expedia.com/Galapagos.dx1371) - [Visit Pastaza](https://expedia.com/Pastaza.dx6239600) - [Visit Morona Santiago](https://expedia.com/Morona-Santiago.dx6239604) ## Trending flights to Santo Domingo de los Tsáchilas These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply. All deals One way Roundtrip ![Copa](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/CM.gif) Mon, Mar 16 - Wed, Mar 25 BOS Boston UIO Quito $306 Roundtrip found 1 hour ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:BOS,to:UIO,departure:3/16/2026TANYT&leg2=from:UIO,to:BOS,departure:3/25/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:305.80&airProductToken=AQpjCjAIw5oBEgM3MDUYwZMBIO_EASjV5ocDMKXphwM4QUAAWAFqA0JBU3IIQUxBQVRaMlMKLwjDmgESAzIxMRjvxAEglHIok-qHAzCL64cDOEFAAFgBagNCQVNyCEFMQUFUWjJTCmMKLwjDmgESAzE1OBiUciDvxAEoxc2IAzC4zogDOEFAAFgBagNCQVNyCEFMQUFUWjJTCjAIw5oBEgM3MDQY78QBIMGTASj204gDMMLWiAM4QUAAWAFqA0JBU3IIQUxBQVRaMlMSCggCEAEYASoCQ00YASIECAEQASgCKAMoBDAL) \*Available to One Key members.