Compare car suppliers to unlock big savings, and package your flight, hotel, and car to save even more.
Enjoy maximum flexibility with penalty-free cancellation on most car rentals.
In South America, multiple suppliers are offering Midsize cars at an excellent price. Compare locations and providers on Expedia.com to find the best deal for what you’re looking for. The airport location generally has the largest selection to choose from.
You can see all the available offers on Midsize rentals in South America and then compare prices from various providers and pick-up locations. Prices may vary depending on which supplier you choose, the pick-up location, and the dates of your trip. You can also browse deals for other car types on our car rentals in South America page.
Each car rental deal has its own cancellation policy. Some bookings are free to cancel while most pre-paid bookings are non-refundable. We recommend filtering by “free cancellation” to see the most flexible options.
Here at Expedia.com, we go the extra mile, so you can too! You’ll select your Midsize car rental in South America from a large inventory and get the best deals available from suppliers in the area. Whether you’re looking for a short or long term car rental we’ve got you covered. You’ll get rewards back from every booking, and can customize your entire trip itinerary, all in one place. We have the best deals, not only on car rentals but also on hotels in South America. Bundle them into one, and you’ll get a vacation package in South America for less.