We needed a couple of 'cheap' nights in Rome before setting off on a cruise and so this was ideal. A little further out than it looks on the map it is nonetheless easy enough to get a bus (more later) or metro into the centre. The main thing is to FOLLOW THE INSTRUCTIONS! This means that if you are arriving late, let them know. There is no permanent front desk and this means just that - unless you let them know to leave you a key, you will be locked out, no question. This actually happened to someone when we were there and although we were sorry and a little concerned (single female) it is no one's fault but yours if you don't just do a few single steps. Lisa is AWESOME! Although we never met her, she sorted transfers and everything with absolutely no trouble and in impeccable English. She is without question the best hotel receptionist we have never met! The room was big, clean, the bathroom was fine but the bed - amazing. We didn't want to get out of it in the morning and for 'post-Rome-sightseeing' old peoples' backs and legs it was heaven. Buses - right; when I was last in Rome (ages ago) you could buy bus tickets almost everywhere, now, not so much. So if you have to go down the Metro to get the tickets (yes, really) why not just get the Metro? Clean, efficient and totally non-scary if you have had previous non-London Underground (or indeed London Underground) experiences which freaked you out.
Pros: Friendly and helpful, clean, quiet - unexpected in Rome. Little extras such as pot-pourri and maps nice.
Cons: If I was to quibble, I would say something to make a drink would be nice as there is no dining room of any kind.
Location: Near the Vatican and bus stops for the rest of Rome.