Otay Mesa, CA
San Diego
Popular places to visit
San Diego Zoo
See nature up-close and personal at one of the country’s largest and most educational zoos.
San Diego Convention Center
Whether you come for Comic-Con or a medical convention, this huge gathering place in the Marina District of San Diego will more than satisfy your needs.
SeaWorld
Visit one of the world’s largest marine parks for talented and amazing and animals, electrifying rides, conservation education and seasonal events.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
Balboa Park
Culture and nature converge in this diverse park located in the heart of the city.
Port of San Diego
Explore the waterfront in San Diego with a trip to Port of San Diego. Wander the seaside and beautiful beaches in the area.
Things to do
Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster
$104
per adult
Crossing Borders: Tijuana Day Trip from San Diego
$93
per adult
80% of travellers recommend
Introduction Rosarito Day Tour from San Diego
$157
per adult
Tijuana: Guided City Tour with Local Food and Beer Tasting
$112
per adult
Stand up Paddle Board Lesson on The San Diego Bay
$25
per adult
100% of travellers recommend
Otay Mesa Hotel Deals
Sheraton San Diego Resort
1380 Harbor Island Dr San Diego CA
$226 nightly
The price is $260 total per night from Feb 6 to Feb 7
$260 total
Feb 6 - Feb 7
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (3,226 reviews)
The room was beautiful
Reviewed on Jan 8, 2026
Bay Club Hotel & Marina
2131 Shelter Island Dr San Diego CA
$139 nightly
The price is $160 total per night from Jan 19 to Jan 20
$160 total
Jan 19 - Jan 20
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, a marina, and a health club. Our guests praise the breakfast and the restaurant in ...
9/10 Wonderful! (3,292 reviews)
I love this hotel. It is the second time staying her within four months. It is clean, the staff are friendly and the views are beautiful! We will definitely come here again.
Reviewed on Jan 13, 2026
The DEXTRO Little Italy, BW Premier Collection
1617 1st Avenue San Diego CA
$110 nightly
The price is $128 total per night from Jan 22 to Jan 23
$128 total
Jan 22 - Jan 23
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
8.8/10 Excellent! (904 reviews)
Paid parking, if you have truck / big SUV there are not enough space. Hotel, view, location are great.
Reviewed on Jan 13, 2026
Courtyard by Marriott San Diego Downtown Little Italy
1646 Front St San Diego CA
$134 nightly
The price is $155 total per night from Jan 19 to Jan 20
$155 total
Jan 19 - Jan 20
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
8.8/10 Excellent! (237 reviews)
i had an early check-in and received an upgraded room!! amazing staff!
Reviewed on Jan 12, 2026
DoubleTree by Hilton Hotel San Diego - Mission Valley
7450 Hazard Center Dr San Diego CA
Fully refundableReserve now, pay when you stay
$120 nightly
The price is $138 total per night from Jan 25 to Jan 26
$138 total
Jan 25 - Jan 26
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy breakfast (surcharge), room service, and a 24-hour fitness center. Our guests praise the helpful ...
8.2/10 Very Good! (1,477 reviews)
Room was excellent. Very comfortable. I love the friendliness of the staff and the location does not get any better than this. the Trolley is right across the street, (a 5 minute walk). You can get to literally "any place" you need to go in San Diego from the trolley. I will definitely stay here ...
Reviewed on Jan 13, 2026
Hilton San Diego Mission Valley
901 Camino Del Rio S San Diego CA
$122 nightly
The price is $141 total per night from Jan 21 to Jan 22
$141 total
Jan 21 - Jan 22
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
8/10 Very Good! (2,281 reviews)
It was nice but plain. The room needed puctures or posters for color.
Reviewed on Jan 11, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Other neighborhoods around Otay Mesa
East Village
Travelers choose East Village for its lively bars. Hop aboard the metro at City College Trolley Station or Park and Market Trolley Station and check out top sights like Petco Park.
Mid-City
If you're spending time in Mid-City, check out sights like Cal Coast Credit Union Open Air Theater or Viejas Arena and hop on the metro to see more the city at SDSU Transit Center Station or Alvarado Station.
Gaslamp Quarter
Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.
Downtown San Diego
4.5/5(8,497 area reviews)
Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.
North Park
4/5(78 area reviews)
North Park is well-liked for its restaurants. You can also take some time to explore sights in the surrounding area like San Diego Zoo and San Diego Natural History Museum.
Little Italy
Little Italy is popular for its captivating waterfront views. Explore top sights like Maritime Museum of San Diego and San Diego Bay, and you can get around town on the metro at County Center - Little Italy Station.
Otay Mesa, CA
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