Otay Mesa, CA
San Diego
Popular places to visit
San Diego Zoo
See nature up-close and personal at one of the country’s largest and most educational zoos.
San Diego Convention Center
Whether you come for Comic-Con or a medical convention, this huge gathering place in the Marina District of San Diego will more than satisfy your needs.
SeaWorld
Visit one of the world’s largest marine parks for talented and amazing and animals, electrifying rides, conservation education and seasonal events.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
Balboa Park
Culture and nature converge in this diverse park located in the heart of the city.
Port of San Diego
Explore the waterfront in San Diego with a trip to Port of San Diego. Wander the seaside and beautiful beaches in the area.
Things to do
Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster
Crossing Borders: Tijuana Day Trip from San Diego
Introduction Rosarito Day Tour from San Diego
From Tijuana: Valle de Guadalupe Private Winery Tour
Tijuana: Guided City Tour with Local Food and Beer Tasting
Otay Mesa Hotel Deals
Sheraton San Diego Resort
Spotless
Reviewed on Jan 6, 2026
Bay Club Hotel & Marina
Beautiful views from room 248! Great service throughout our stay from all the departments! Quiet, serenely quiet which we really enjoyed. Everything was clean, spacious, kept up and easy to navigate.
Reviewed on Jan 6, 2026
Courtyard by Marriott San Diego Downtown Little Italy
I enjoyed the stay. Staff was pleasant just upset the ice machine didn’t work and could of used more towels
Reviewed on Jan 5, 2026
The DEXTRO Little Italy, BW Premier Collection
Linen service for the room, staff, and fruit-infused water.
Reviewed on Jan 5, 2026
DoubleTree by Hilton Hotel San Diego - Mission Valley
The staff was kind and courteous , the rooms were clean, well and supplied with necessities. We received free cookies upon entry, the gym, indoor pool and jacuzzi were amazing. The only surprise that was quite significant and is not mentioned in the Expedia or hotel site description is that doubletree ...
Reviewed on Jan 5, 2026
Hilton San Diego Mission Valley
The room was nice, clean, and quiet.
Reviewed on Jan 6, 2026
Other neighborhoods around Otay Mesa
East Village
Travelers choose East Village for its lively bars. Hop aboard the metro at City College Trolley Station or Park and Market Trolley Station and check out top sights like Petco Park.
Gaslamp Quarter
Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.
Downtown San Diego
Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.
Marina District
Known for its fantastic nightlife and captivating waterfront views, there's plenty to explore in Marina District. Check out top attractions like Seaport Village and The Rady Shell at Jacobs Park, and jump on the metro at Seaport Village Station or Convention Center Station to see more of the city.
North Park
North Park is well-liked for its restaurants. You can also take some time to explore sights in the surrounding area like San Diego Zoo and San Diego Natural History Museum.
Little Italy
Little Italy is popular for its captivating waterfront views. Explore top sights like Maritime Museum of San Diego and San Diego Bay, and you can get around town on the metro at County Center - Little Italy Station.
Otay Mesa, CA
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