Otay Mesa, CA
San Diego
Visit Otay Mesa
Stay near popular Otay Mesa attractions
Things to do
Stand up Paddle Board Lesson on The San Diego Bay
$25
per adult
100% of travellers recommend
From Tijuana: Valle de Guadalupe Private Winery Tour
$143
per adult
Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster
$99
per adult
Tijuana: Guided City Tour with Local Food and Beer Tasting
$114
per adult
Otay Mesa Hotel Deals
Paradise Point Resort & Spa
1404 Vacation Rd San Diego CA
$325 nightly
The price is $374 total per night from Aug 9 to Aug 10
$374 total
Aug 9 - Aug 10
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
8.8/10 Excellent! (2,727 reviews)
"Unexpected $50 nightly per car parking fee and an add on $50 per day resort fee. It's a good place but no longer worth the add on fees."
Reviewed on Jul 10, 2026
Wyndham San Diego Bayside
1355 N Harbor Drive San Diego CA
$182 nightly
The price is $211 total per night from Jul 19 to Jul 20
$211 total
Jul 19 - Jul 20
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,291 reviews)
"Honestly I was expecting much, much worse based on the reviews I had seen of this hotel so I was pleasantly surprised by most of the staff and the quality of the room. We were given our daily coffee vouchers, we had the same woman every morning and she was absolutely wonderful but I did not catch ..."
Reviewed on Jul 10, 2026
Best Western Seven Seas
411 Hotel Circle South San Diego CA
$123 nightly
The price is $142 total per night from Jul 27 to Jul 28
$142 total
Jul 27 - Jul 28
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the restaurant in our ...
8/10 Very Good! (3,711 reviews)
"The Staff is great, every one of them. The grounds are very meticulously maintained by the attentive groundskeepers (who are also very nice). The shower was fantastic! Excellent water pressure 👌 and the food was very good quality 👌 We’ve been here before, and we’ll be back for sure!"
Reviewed on Jul 11, 2026
Hard Rock Hotel San Diego
207 5th Ave San Diego CA
$225 nightly
The price is $261 total per night from Jul 19 to Jul 20
$261 total
Jul 19 - Jul 20
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
9/10 Wonderful! (4,024 reviews)
"Didn’t feel like a hard rock"
Reviewed on Jul 11, 2026
Handlery Hotel
950 Hotel Cir N San Diego CA
$153 nightly
The price is $175 total per night from Aug 2 to Aug 3
$175 total
Aug 2 - Aug 3
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff ...
8.4/10 Very Good! (2,719 reviews)
"When we drove up I was surprised to see it was not a hotel but more like a motel. There are three separate buildings that are more like apartments. When I noticed they were placing us in the second units I asked if there was something else. I was told they were booked to capacity. Went to the room ..."
Reviewed on Jul 11, 2026
Bahia Resort Hotel
998 W Mission Bay Dr San Diego CA
$290 nightly
The price is $333 total per night from Aug 11 to Aug 12
$333 total
Aug 11 - Aug 12
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy a beach locale, breakfast (surcharge), and 24-hour room service. Our guests praise the pool and the restaurant ...
8.8/10 Excellent! (2,242 reviews)
"Wonderful resort"
Reviewed on Jul 11, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Otay Mesa
Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa
Downtown San Diego
Petco Park and Seaport Village are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.
Pacific Beach
The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.
Mission Beach
If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.
Gaslamp Quarter
Fantastic nightlife and popular shops are a few of the things travelers enjoy most about Gaslamp Quarter. A visit to Gaslamp Museum at the Davis-Horton House or Spreckels Theater is also recommended, and you can jump aboard the metro at Gaslamp Quarter Station to get around town.
Mission Bay
If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.
Otay Mesa, CA
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