Otay Mesa, CA
San Diego
Visit Otay Mesa
Stay near popular Otay Mesa attractions
Things to do
Stand up Paddle Board Lesson on The San Diego Bay
$25
per adult
100% of travellers recommend
From Tijuana: Valle de Guadalupe Private Winery Tour
$143
per adult
Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster
$99
per adult
Tijuana: Guided City Tour with Local Food and Beer Tasting
$114
per adult
Otay Mesa Hotel Deals
Paradise Point Resort & Spa
1404 Vacation Rd San Diego CA
$304 nightly
The price is $349 total per night from Aug 9 to Aug 10
$349 total
Aug 9 - Aug 10
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
8.8/10 Excellent! (2,731 reviews)
"Great resort. Family friendly!!!"
Reviewed on Jul 11, 2026
Wyndham San Diego Bayside
1355 N Harbor Drive San Diego CA
$182 nightly
The price is $211 total per night from Aug 3 to Aug 4
$211 total
Aug 3 - Aug 4
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,296 reviews)
"Our favorite place to stay when in San Diego!"
Reviewed on Jul 12, 2026
Best Western Seven Seas
411 Hotel Circle South San Diego CA
$123 nightly
The price is $142 total per night from Jul 27 to Jul 28
$142 total
Jul 27 - Jul 28
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the restaurant in our ...
8/10 Very Good! (3,716 reviews)
"Room was clean and modern but it had underlying odors due to its age. My husband gets sore throat from mold/mildew and he got it in the room (we arrived 8:30 pm for a be night). Fridge didn’t work."
Reviewed on Jul 12, 2026
Hard Rock Hotel San Diego
207 5th Ave San Diego CA
$225 nightly
The price is $261 total per night from Jul 19 to Jul 20
$261 total
Jul 19 - Jul 20
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
9/10 Wonderful! (4,034 reviews)
"Great location! Easy to walk to Petco park and all around down town. Clean, felt safe!"
Reviewed on Jul 11, 2026
Handlery Hotel
950 Hotel Cir N San Diego CA
$153 nightly
The price is $175 total per night from Aug 2 to Aug 3
$175 total
Aug 2 - Aug 3
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff ...
8.4/10 Very Good! (2,723 reviews)
"Very good and very close to fashion valley"
Reviewed on Jul 12, 2026
Bahia Resort Hotel
998 W Mission Bay Dr San Diego CA
$275 nightly
The price is $317 total per night from Aug 11 to Aug 12
$317 total
Aug 11 - Aug 12
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy a beach locale, breakfast (surcharge), and 24-hour room service. Our guests praise the pool and the restaurant ...
8.8/10 Excellent! (2,253 reviews)
"Paid $1,700 for 2 nights bút not good services, Honestly, this is a disappointed trip while we were too excited to experience. We went there by train, and the room was upstairs + the end of the resort, we had to walk a long way into our room, we have kids + luggages but we didn’t get any help from ..."
Reviewed on Jul 12, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Otay Mesa
Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa
Downtown San Diego
Petco Park and Seaport Village are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.
Pacific Beach
The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.
Mission Beach
If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.
Gaslamp Quarter
Fantastic nightlife and popular shops are a few of the things travelers enjoy most about Gaslamp Quarter. A visit to Gaslamp Museum at the Davis-Horton House or Spreckels Theater is also recommended, and you can jump aboard the metro at Gaslamp Quarter Station to get around town.
Mission Bay
If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.
Otay Mesa, CA
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