Otay Mesa, CA
San Diego
Visit Otay Mesa
Stay near popular Otay Mesa attractions
Things to do
Crossing Borders: Tijuana Day Trip from San Diego
$93
per adult
82% of travellers recommend
Stand up Paddle Board Lesson on The San Diego Bay
$25
per adult
100% of travellers recommend
From Tijuana: Valle de Guadalupe Private Winery Tour
$143
per adult
Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster
$99
per adult
Tijuana: Guided City Tour with Local Food and Beer Tasting
$114
per adult
Otay Mesa Hotel Deals
Wyndham San Diego Bayside
1355 N Harbor Drive San Diego CA
$180 nightly
The price is $209 total per night from Jul 19 to Jul 20
$209 total
Jul 19 - Jul 20
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,287 reviews)
"Balcony view was amazing. No microwave. Friendly staff. Clean room.Walking distance to Seaport Village was close by, along with other attractions. Will plan on staying here again."
Reviewed on Jul 10, 2026
Paradise Point Resort & Spa
1404 Vacation Rd San Diego CA
$325 nightly
The price is $374 total per night from Aug 9 to Aug 10
$374 total
Aug 9 - Aug 10
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
8.8/10 Excellent! (2,723 reviews)
"We love the place we will go back"
Reviewed on Jul 9, 2026
Hard Rock Hotel San Diego
207 5th Ave San Diego CA
$220 nightly
The price is $255 total per night from Jul 19 to Jul 20
$255 total
Jul 19 - Jul 20
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
9/10 Wonderful! (4,016 reviews)
"Clean room. The location was perfect for our visit(going to Petco park). The pool is heated which I wish I would have known ahead of time, it looked great. Everyone was friendly."
Reviewed on Jul 10, 2026
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
2485 Hotel Circle Place San Diego CA
$127 nightly
The price is $146 total per night from Aug 2 to Aug 3
$146 total
Aug 2 - Aug 3
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (2,797 reviews)
"Free breakfast included!"
Reviewed on Jul 9, 2026
Bahia Resort Hotel
998 W Mission Bay Dr San Diego CA
$279 nightly
The price is $321 total per night from Aug 9 to Aug 10
$321 total
Aug 9 - Aug 10
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy a beach locale, breakfast (surcharge), and 24-hour room service. Our guests praise the pool and the restaurant ...
8.8/10 Excellent! (2,235 reviews)
"Beautiful landscaped well kept grounds. The rooms were a bit outdated and not super clean. We brought our concern to the front desk staff and they sent housekeeping to clean the room. The gorgeous grounds, pool, beachy area, pickle ball courts, little kids park and daily activities were enough to ..."
Reviewed on Jul 9, 2026
Bay Club Hotel & Marina
2131 Shelter Island Dr San Diego CA
$230 nightly
The price is $265 total per night from Aug 10 to Aug 11
$265 total
Aug 10 - Aug 11
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, a marina, and a health club. Our guests praise the breakfast and the restaurant in ...
9.2/10 Wonderful! (3,738 reviews)
"Truly enjoyed our stay here in San Diego! The staff is super friendly and helpful! Room was super comfortable and the restaurant was top notch!"
Reviewed on Jul 10, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Otay Mesa
Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa
Downtown San Diego
Petco Park and Seaport Village are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.
Pacific Beach
The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.
Mission Beach
If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.
Gaslamp Quarter
Fantastic nightlife and popular shops are a few of the things travelers enjoy most about Gaslamp Quarter. A visit to Gaslamp Museum at the Davis-Horton House or Spreckels Theater is also recommended, and you can jump aboard the metro at Gaslamp Quarter Station to get around town.
Mission Bay
If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.
Otay Mesa, CA
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