Otay Mesa, CA
San Diego
Popular places to visit
San Diego Zoo
See nature up-close and personal at one of the country’s largest and most educational zoos.
San Diego Convention Center
Whether you come for Comic-Con or a medical convention, this huge gathering place in the Marina District of San Diego will more than satisfy your needs.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
Petco Park
Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.
Mission Beach
A favorite vacation spot for 100 years, this seaside village combines old-fashioned charm with modern amenities.
SeaWorld
Visit one of the world’s largest marine parks for talented and amazing and animals, electrifying rides, conservation education and seasonal events.
Things to do
San Diego USS Midway with Waterfront Walking Tour
From Tijuana: Valle de Guadalupe Private Winery Tour
Crossing Borders: Tijuana Day Trip from San Diego
Tijuana: Guided City Tour with Local Food and Beer Tasting
Otay Mesa Hotel Deals
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Reviewed on Jul 28, 2025
Handlery Hotel
Reviewed on Jul 29, 2025
Wyndham San Diego Bayside
Reviewed on Jul 30, 2025
Manchester Grand Hyatt San Diego
Reviewed on Jul 28, 2025
The Dana on Mission Bay
Reviewed on Jul 30, 2025
Marriott Marquis San Diego Marina
Reviewed on Jul 28, 2025
Other neighborhoods around Otay Mesa
Mid-City
If you're spending time in Mid-City, check out sights like Cal Coast Credit Union Open Air Theater or Viejas Arena and hop on the metro to see more the city at SDSU Transit Center Station or Alvarado Station.
Gaslamp Quarter
Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.
Downtown San Diego
Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.
North Park
North Park is well-liked for its restaurants. You can also take some time to explore sights in the surrounding area like San Diego Zoo and San Diego Natural History Museum.
Little Italy
Little Italy is popular for its captivating waterfront views. Explore top sights like Maritime Museum of San Diego and San Diego Bay, and you can get around town on the metro at County Center - Little Italy Station.
Del Cerro
Del Cerro might not have many top sights, but Cal Coast Credit Union Open Air Theater and Viejas Arena are two attractions nearby that you can check out.
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