San Luis Vacation Rentals

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Vacation Rentals in San Luis

Our top choices for San Luis vacation rentals

Charming 2-bedroom townhome with WiFi, AC in East San Luis, AZ.

10.0 out of 10, Exceptional, (3)
"I had a great stay! The home was very nice, clean, and quiet—just what I was looking for. Everything was well-kept and comfortable, making it easy to relax. The neighborhood felt peaceful and safe, and I really appreciated how tidy the space was. I would definitely stay here again and recommend it to anyone looking for a calm and pleasant place to stay."
$160 nightly
The price is $175
Aug 29 - Aug 30
Total with taxes and fees
Charming 2-bedroom townhome with WiFi, AC in East San Luis, AZ.

La Casa de Burro, Newly remodeled family and pet friendly home with a pool!

2.0 star property
9.8 out of 10, Exceptional, (7)
"The decor is beautiful - the beds were clean and comfortable- and the house was just all around good vibes "
$270 nightly
The price is $295
Sep 2 - Sep 3
Total with taxes and fees
La Casa de Burro, Newly remodeled family and pet friendly home with a pool!

OCO-Heated pool for additional fee and spacious 4br home for your comfort.

10.0 out of 10, Exceptional, (97)
"Property owners are fantastic.... I would highly recommend. "
OCO-Heated pool for additional fee and spacious 4br home for your comfort.

Family-Friendly 3BR house in Prime Location-near hospital – PETS STAY FREE

$324 nightly
The price is $354
Aug 29 - Aug 30
Total with taxes and fees
Family-Friendly 3BR house in Prime Location-near hospital – PETS STAY FREE

Yuma Townhouse - Centrally Located!

10.0 out of 10, Exceptional, (73)
"Great place to stay. Quiet and friendly neighborhood. Centrally located and although compact everyone had plenty of room for privacy. Will definitely stay here again when needing a place to stay in Yuma."
$216 nightly
The price is $236
Aug 29 - Aug 30
Total with taxes and fees
Yuma Townhouse - Centrally Located!

Beautiful Desert Oasis 4-bedroom home

9.8 out of 10, Exceptional, (26)
"House was clean, check in was simple, and it was as advertised. We had a group of friends looking for a relaxing weekend and this place provided it. Place would be good for a family as well. "
Beautiful Desert Oasis 4-bedroom home

Home away from home-Quiet cozy casita

9.6 out of 10, Exceptional, (7)
"Our family enjoyed our time at this property. Very cozy and had everything we needed. Host even ensured we had enough towels and was very accommodating. Neighborhood was great and felt very safe to take a run."
$300 nightly
The price is $328
Sep 8 - Sep 9
Total with taxes and fees
Home away from home-Quiet cozy casita

beautiful home Sleeps 8, but 6 comfortably

9.4 out of 10, Exceptional, (51)
"Our second time here, vey comfortable. Back yard could be an oasis with a bit of work."
beautiful home Sleeps 8, but 6 comfortably

Yuma Boho/Airy 3 bedroom home with free parking

10.0 out of 10, Exceptional, (62)
"Great property for us! Fans in every room, which is a huge plus! Comfortable living room furniture as well."
Yuma Boho/Airy 3 bedroom home with free parking

One story fully furnished townhouse

9.4 out of 10, Exceptional, (49)
"We enjoyed our stay in Yuma very much! Great house and location. "
$199 nightly
The price is $217
Aug 29 - Aug 30
Total with taxes and fees
One story fully furnished townhouse

Experience Yuma's History at the Crim House perfect for a stay or family venues

10.0 out of 10, Exceptional, (44)
"The house was perfect for our stay, very clean, well stocked with coffee and snacks and had very good communication with the owner. Would definitely stay at the Crim house again. "
Experience Yuma's History at the Crim House perfect for a stay or family venues

TMK-Spacious 4br home with pool for your comfort. EV charger available

10.0 out of 10, Exceptional, (48)
"Large comfy house. "
TMK-Spacious 4br home with pool for your comfort. EV charger available

Lovely Pool Home in a Quiet Upscale Neighborhood!

9.0 out of 10, Wonderful, (122)
"Great Neighborhood! Second time staying here & we love the house Pool would be nice but just not the time of year "
Lovely Pool Home in a Quiet Upscale Neighborhood!

Vista del Valle

10.0 out of 10, Exceptional, (132)
"Safe,comfortable and very clean "
$211 nightly
The price is $231
Sep 3 - Sep 4
Total with taxes and fees
Vista del Valle

Centrally Located Yuma Retreat w/ Fenced Patio

3.5 star property
9.0 out of 10, Wonderful, (4)
"We didn't do much cooking but it was so wonderful to have a full kitchen! Not something you get with a hotel room. All the amenities of home! Very comfortable and convenient location in Yuma. "
Centrally Located Yuma Retreat w/ Fenced Patio

Yumas Best Kept Secret

10.0 out of 10, Exceptional, (84)
"The home was very nicely kept and clean. It is in a nice location. We were very comfortable and enjoyed our stay. "
Yumas Best Kept Secret

Yuma Vacation Rental w/ Private Pool & Patio!

3.0 star property
Yuma Vacation Rental w/ Private Pool & Patio!

Cozy and Bright 3 BR | 2 BA home in the Yuma Foothills

10.0 out of 10, Exceptional, (41)
"We look forward to booking again for next year visit to Yuma."
Cozy and Bright 3 BR | 2 BA home in the Yuma Foothills

Year-Round Yuma Escape Near Dtwn: Pets Welcome!

10.0 out of 10, Exceptional, (9)
"We had fun the house was clean, never felt crowded and it was close to our desired locations"
Year-Round Yuma Escape Near Dtwn: Pets Welcome!

Cozy condo in Yuma!

9.2 out of 10, Wonderful, (5)
"It was nice "
$169 nightly
The price is $184
Aug 29 - Aug 30
Total with taxes and fees
Cozy condo in Yuma!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top San Luis Hotel Reviews

Find out more about San Luis

Find out more about San Luis

Everything you need to know about San Luis vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the San Luis vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect San Luis vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

San Luis vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in San Luis. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit San Luis in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $175 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on San Luis rentals

At Expedia, we put the best San Luis vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top San Luis rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream San Luis vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around San Luis. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently asked questions

Are there vacation rentals in San Luis?

Yes, we give you a choice of vacation rentals near popular local attractions in San Luis, or you can select a more secluded option if you're looking for relaxation. San Luis is known for its parks.

What's the top vacation rental in San Luis?

La Casa de Burro, Newly remodeled family and pet friendly home with a pool!: Visitors like this San Luis vacation home rental. It offers a fireplace, a hot tub, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a dishwasher, a stovetop, and a microwave.

What can I see and do in San Luis?

Explore the area and family-friendly sights such as Saihati Camel Farm, or get out into nature at a spot like Colorado River. In the larger area, you’ll find San Luis Lakes State Park and Garita Entrance to Mexico.

What are vacation rentals like in San Luis?

Vacation rentals are privately owned properties you can book for a couple days or more in San Luis. Vacation rentals provide amenities like kitchens and laundry facilities so you'll feel right at home. If you're concerned about a clean environment, a vacation rental can provide a sense of seclusion away from public hotel elevators and busy concierge desks while still allowing you the enjoyment of travel. You'll also get more space in a vacation rental than in a traditional hotel, which is another reason why a vacation rental is a great option for family gatherings.