Find hotels in Santa María Centro from $109

The best area to stay in Santa María Centro is the central downtown district, particularly around Plaza San Martín and along Avenida General López.This area serves as the heart of Santa María, offering a convenient and pleasant experience for visitors. It's characterized by its tree-lined streets, historic buildings, and a concentration of shops, restaurants, and cultural institutions. Plaza San Martín is the main public square, often bustling with activity and surrounded by important landmarks.Couples will find this area ideal for a relaxed and enjoyable trip. You're within walking distance of many local eateries, boutique stores, and the beautiful architecture of the Cathedral Metropolitana. Evening strolls through the plaza or along pedestrian-friendly streets offer a pleasant way to experience the city.Solo travelers will also appreciate the ease and accessibility of this central location. It's simple to navigate on foot, allowing for independent exploration of galleries and cafes.

The best time to visit Santa María Centro is during the spring (September to November) and autumn (March to May) months, when the weather is most pleasant for exploring.During these seasons, you'll experience mild temperatures and less humidity, making it comfortable for walking around the city's plazas and historic sites. Spring brings blooming jacaranda trees, adding a beautiful touch to the city, while autumn offers crisp air and comfortable days.

With Expedia, you earn OneKeyCash™* on eligible Santa María Centro hotel bookings for every dollar you spend – just join our One Key™ travel rewards program to get started. It's free to join, and you'll unlock our lowest Member Prices as soon as you're signed in. On top of this, you could also save significantly by bundling your hotel and flights together on Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.