St. Marys Vacation Rentals

Start date: Check-in selected.
To Date
End date: Check-out
  • Bundle & Save

    Get more, spend less whenever you see Bundle & Save deals
  • OneKeyCash

    Earn OneKeyCash on all your eligible bookings
  • Upfront pricing

    We are not like the others - we include taxes and fees

Check prices for these dates

Our top choices for St. Marys vacation rentals

10.0 out of 10, Exceptional, (404)
"Needed a a quick getaway....it was perfect "
United States
Lee F.
$129 nightly
The price is $135
Dec 15 - Dec 16
Total with taxes and fees
Beautiful Rustic Barn just waiting for you to kick back and relax.

Apartment in West Des Moines

Historic Valley Junction Loft
9.8 out of 10, Exceptional, (21)
"Great location, clean and comfy place. The location is charming, with a number of shops and restaurants next door. Would definitely stay here again. "
United States
Rebecca S.
$124 nightly
The price is $139
Dec 19 - Dec 20
Total with taxes and fees
Historic Valley Junction Loft
9.6 out of 10, Exceptional, (11)
"Just as advertise prompt response from host clean and apt was as advertised!! Great stay"
United States
Raul N.
$172 nightly
The price is $174
Dec 18 - Dec 19
Total with taxes and fees
West Des Moines- Garage, Gym, Pool, Jordan Creek

Vacation Home in Greater South Side

Family & Pet-Friendly 2BR Retreat Near Downtown
10.0 out of 10, Exceptional, (12)
"Great location and had everything we needed! "
United States
Cooper R.
$215 nightly
The price is $241
Dec 16 - Dec 17
Total with taxes and fees
Family & Pet-Friendly 2BR Retreat Near Downtown
9.4 out of 10, Exceptional, (18)
"Had a great stay, will come back!"
United States
Spring A.
$216 nightly
The price is $242
Dec 14 - Dec 15
Total with taxes and fees
• Lively Cottage 2 King Beds 4 Bed 2 Bath •

Apartment in West Des Moines

Valley Junction Getaway
10.0 out of 10, Exceptional, (1)
"Great place to stay for a night. Everything was clean and neat. "
United States
Nicole C.
$108 nightly
The price is $121
Dec 15 - Dec 16
Total with taxes and fees
Valley Junction Getaway
9.8 out of 10, Exceptional, (23)
"Clean, well layed prepared apartment that meets all our needs.The massage chair is the perfect addition. "
United States
Scott L.
$198 nightly
The price is $222
Dec 14 - Dec 15
Total with taxes and fees
The Carmel/Bold/Massage /Chair Spacious / 3D Wall / Pool / Gym / Tanning Bed
8.4 out of 10, Very Good, (5)
"Excellent location and apartment. Very private yet close to everything. Highly recommend it."
United States
Mohammad B.
$159 nightly
The price is $178
Dec 14 - Dec 15
Total with taxes and fees
1-bedroom, 3 Gig-Fiber WiFi, timbered/view setting in WDM near RecPlex/DMU
10.0 out of 10, Exceptional, (7)
"Our host was amazing. Went above to make sure we had a great stay. Very personable..We both enjoyed visiting with her and learning more about the area. We will definitely return to the Hen House"
United States
Madonna
$182 nightly
The price is $191
Dec 14 - Dec 15
Total with taxes and fees
The Hen House Country Living with Farm Life Appeal Indianola, IA

Vacation Home in Des Moines

Beautiful home minutes from downtown!
9.6 out of 10, Exceptional, (26)
"This worked out great for us while we were in town for a wedding. Plenty of room for 4 of us and a dog!"
United States
Mona J.
$245 nightly
The price is $274
Dec 14 - Dec 15
Total with taxes and fees
Beautiful home minutes from downtown!
10.0 out of 10, Exceptional, (4)
"The house was absolutely gorgeous! It was very comfortable and had everything we needed. I would most definitely stay here again!"
United States
Heather G.
$277 nightly
The price is $311
Dec 15 - Dec 16
Total with taxes and fees
Covered Bridge Haven - 3-bedroom house with themed rooms in Winterset

Vacation Home in Southwestern Hills

Centrally Located Wooded A-Frame
10.0 out of 10, Exceptional, (4)
"Beautiful place, good view from the deck. "
United States
Cory S.
$260 nightly
The price is $291
Dec 17 - Dec 18
Total with taxes and fees
Centrally Located Wooded A-Frame
$160 nightly
The price is $168
Dec 16 - Dec 17
Total with taxes and fees
Cozy pond house nestled in nature waiting for you to enjoy
9.8 out of 10, Exceptional, (50)
"Great place"
United States
Rebecca E.
$196 nightly
The price is $220
Jan 5 - Jan 6, 2026
Total with taxes and fees
Newly Remodeled Brick Home with wall Sculptures by the Airport
2.0 star property
8.6 out of 10, Excellent, (34)
"Nice place for the family! "
United States
Brandon G.
$286 nightly
The price is $320
Dec 15 - Dec 16
Total with taxes and fees
Charming 3-bedroom house with WiFi and fitness room and hot tub, playground
9.8 out of 10, Exceptional, (8)
"Clean and comfortable. We were here from KC for our daughter’s wedding and the space fit our needs perfectly. Enjoyed the location just outside of town. "
United States
Kim P.
$453 nightly
The price is $508
Dec 14 - Dec 15
Total with taxes and fees
Elegant Home in Agrihood w/ Modern Comforts, "Luxurious Retreat in Iowa's First Agrihood: Minutes to
10.0 out of 10, Exceptional, (83)
"Beautiful property with great patios. "
United States
Chris S.
$370 nightly
The price is $389
Jan 3 - Jan 4, 2026
Total with taxes and fees
Serenity Heights - Peaceful Country Acres with beautiful view in every direction
2.0 star property
$175 nightly
The price is $196
Dec 18 - Dec 19
Total with taxes and fees
West Des Moines- Garage Gym Pool Jordan Creek
$520 nightly
The price is $582
Dec 15 - Dec 16
Total with taxes and fees
Chic Urban Retreat in Agrihood Community
9.0 out of 10, Wonderful, (2)
"We were here to help our daughter move. The apartment is in the same complex which was very helpful. There is plenty to do if here for vacation. The two state parks we went to were fairly close and nice. There are many stores, a mall, and plenty of restaurants within a ten minute drive. Des Moines is 20-30 minutes."
United States
H and P H.
$209 nightly
The price is $234
Dec 14 - Dec 15
Total with taxes and fees
Covered Garage | Updated| New $50k Fitness Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top St. Marys Hotel Reviews

Find out more about St. Marys

Everything you need to know about St. Marys vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the St. Marys vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect St. Marys vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

St. Marys vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in St. Marys. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit St. Marys in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $135 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on St. Marys rentals

At Expedia, we put the best St. Marys vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top St. Marys rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream St. Marys vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around St. Marys. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently asked questions

Can I find a vacation rental in St. Marys?

Yes, there are vacation rentals close to well known attractions in St. Marys, or you can select a more secluded option if you're looking for relaxation.

What's the top vacation rental in St. Marys?

AMAZING & A PARTY BARN… HOT TUB, PL TBl, PNG PNG, & ARCADE! ACCESS TO POOLS!: Visitors like this St. Marys vacation home rental. It offers a fireplace, a balcony, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. It has 6 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. It offers a garden, a selection of games, and a hot tub so you can immerse yourself in your vacation.

What’s there to see and do in St. Marys?

While exploring the area, visit family-friendly sights like Blank Park Zoo, or get outside and enjoy nature at Indianola Pickard Sports Complex. In the larger area, you’ll find Des Moines Metro Opera and Simpson College.

What’s a vacation rental in St. Marys like?

A vacation rental is a private property where you can stay for a long or short time in St. Marys. Vacation rentals provide amenities such as WiFi and washers and dryers so you'll feel just like you're staying in your own home. If you're concerned about cleanliness, a vacation rental can provide a sense of privacy away from public hotel elevators and busy lobbies while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is an attractive choice for families.