Title: Visit Santa Ana: 2026 Santa Ana, Antigua Guatemala Travel Guide | Expedia.com [Hotels in Santa Ana](https://expedia.com/Santa-Ana-Antigua-Guatemala-Hotels.0-n553248635975847775-0.Travel-Guide-Filter-Hotels)[Flights to Antigua Guatemala](https://expedia.com/Cheap-Flights-To-Antigua-Guatemala.d180589.Travel-Guide-Flights)[Things to do in Antigua Guatemala](https://expedia.com/Things-To-Do-In-Antigua-Guatemala.d180589.Travel-Guide-Activities)[Car Rentals in Santa Ana](https://expedia.com/Car-Rentals-In-Santa-Ana.d553248635975847775.Car-Rental-Guide)[Santa Ana Vacations](https://expedia.com/Santa-Ana.d553248635975847775.Destination-Travel-Guides) # Santa Ana ## Antigua Guatemala ![Iglesia de Nuestra Señora de Santa Ana, aldea Santa Ana en Antigua Guatemala.](https://images.trvl-media.com/place/553248635975847775/dbfc8e66-dcda-4ff9-9ea4-b39c7cec35ab.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Iglesia de Nuestra Señora de Santa Ana, aldea Santa Ana en Antigua Guatemala.](https://images.trvl-media.com/place/553248635975847775/dbfc8e66-dcda-4ff9-9ea4-b39c7cec35ab.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ## Visit Santa Ana Things to do Hotels Where to stay [Antigua Guatemala Travel Guide](https://expedia.com/Antigua-Guatemala.dx180589) --- ### Popular places to visit ![Antigua, Guatemala, volcano](https://images.trvl-media.com/place/6105464/d466ff39-ee07-4e6d-baed-58b1a51c8314.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Central Park Enjoy the volcano viewpoints and explore Central Park, a lovely green space in Antigua Guatemala. Discover the area's shops, or seek out its local tours. [](https://expedia.com/Central-Park-Historic-Center.d6105464.Vacation-Attraction) ![Panoramic inside the ruins of Antigua's Cathedral, one of the many buildings that collapsed after the earthquake that destroyed the city in 1773.](https://images.trvl-media.com/place/180589/1dda07b1-9d1c-4f3b-b652-12e488ea88b5.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Antigua Guatemala Cathedral After visiting Antigua Guatemala Cathedral, make a plan to see the other sights and activities in Antigua Guatemala. Discover the area's volcano viewpoints, or seek out its local tours. [](https://expedia.com/Antigua-Guatemala-Cathedral-Historic-Center.d6266484.Vacation-Attraction) ![Recent trip to Antigua, Guatemala.](https://images.trvl-media.com/place/180589/2b05b9ea-3f0a-4375-9661-84349dc65ef7.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Santa Catalina Arch Find out about the history of Antigua Guatemala when you spend time at Santa Catalina Arch. Discover the volcano viewpoints and shops in this romantic area. [](https://expedia.com/Santa-Catalina-Arch-Historic-Center.d553248621532619480.Vacation-Attraction) ![ Traditional vase and jar at market in Antigua, Guatemala.](https://images.trvl-media.com/place/553248621532963883/3ec95ff3-7959-4920-bfc4-dfcbe0674a2f.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Antigua Market During your trip to Antigua Guatemala, you can enjoy retail therapy at Antigua Market. Discover the volcano viewpoints in this family-friendly area, or enjoy its local tours. [](https://expedia.com/Antigua-Market-Antigua-Guatemala.d553248621532963883.Vacation-Attraction) ![A one of a kind facade ](https://images.trvl-media.com/place/180589/12305006-65ce-4369-af37-4e05b1482005.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### La Merced Church After visiting La Merced Church, make a plan to see the other sights and activities in Antigua Guatemala. Discover the area's shops, or seek out its local tours. [](https://expedia.com/La-Merced-Church-Antigua-Guatemala.d6105472.Vacation-Attraction) ![Cerro de la Cruz Antigua Guatemala](https://images.trvl-media.com/place/553248635975478041/72941465-dbed-49b1-8a26-b0c021969c22.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Cerro de La Cruz You can find out about the history of Antigua Guatemala when you stop by Cerro de La Cruz. Discover the area's volcano viewpoints, or seek out its local tours. [](https://expedia.com/Cerro-De-La-Cruz-Antigua-Guatemala.d553248635975478041.Vacation-Attraction) ### Things to do ![Antigua: ATV Guided Sunset Tour](https://mediaim.expedia.com/localexpert/48070707/8c6c8cbf-7de5-420d-9021-6857de969452.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Antigua: ATV Guided Sunset Tour $65 per adult **100%** of travellers recommend [](https://expedia.com/things-to-do/antigua-atv-guided-sunset-tour.a48070707.activity-details) ![Acatenango Volcano Tour with Overnight from Antigua](https://mediaim.expedia.com/localexpert/1353190/c07af298-10dc-41b8-86f2-f11e9917523e.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Acatenango Volcano Overnight Tour $119 per adult [](https://expedia.com/things-to-do/acatenango-volcano-overnight-tour.a1353190.activity-details) ![Viewpoint](https://mediaim.expedia.com/localexpert/1353381/e7e07cdc-9932-487a-b2c2-c9429a7614fe.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Lake Atitlan Day Tour From Antigua $130 per adult **100%** of travellers recommend [](https://expedia.com/things-to-do/lake-atitlan-day-tour-from-antigua.a1353381.activity-details) ![Picture 5 for Activity From Antigua: Pacaya Volcano Trek](https://mediaim.expedia.com/localexpert/4752068/1c69856b-8dcc-4431-92dc-9f40f7df8804.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### From Antigua: Pacaya Volcano Trek $23 per adult **92%** of travellers recommend [](https://expedia.com/things-to-do/from-antigua-pacaya-volcano-trek.a4752068.activity-details) ![Mold around 120g of chocolates](https://mediaim.expedia.com/localexpert/1349162/80885578-3970-4da0-85f9-47374a6580ca.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Bean-to-Bar Chocolate Workshop in ChocoMuseo Antigua $32 per adult **100%** of travellers recommend [](https://expedia.com/things-to-do/bean-to-bar-chocolate-workshop-in-chocomuseo-antigua.a1349162.activity-details) ![From Antigua: 2-Day Acatenango Volcano Hiking Tour with Food](https://mediaim.expedia.com/localexpert/4750118/bc93a073-7009-4fd6-aa72-9db283ab8399.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### From Antigua: 2-Day Acatenango Volcano Hiking with Guide $53 per adult [](https://expedia.com/things-to-do/from-antigua-2-day-acatenango-volcano-hiking-with-guide.a4750118.activity-details) [See all activities in Antigua Guatemala](https://expedia.com/Things-To-Do-In-Antigua-Guatemala.d180589.Travel-Guide-Activities) --- ## Santa Ana Hotel Deals ![Casa Buho B&B](https://images.trvl-media.com/lodging/92000000/91820000/91818800/91818768/2c2e8198_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Casa Buho B&B 77 Calle del Agua Antigua Guatemala Guatemala $66 nightly $80 total Feb 16 - Feb 17 Total with taxes and fees Stay at this hotel in Antigua Guatemala. Enjoy free WiFi, free parking, and daily housekeeping. Popular attractions Casa Santo Domingo Museum and Central Park ... 9/10 Wonderful! (48 reviews) Me encantó el lugar ! Es espectacular un jardín lindísimo, el desayuno excelente y la atención de igual manera definitivamente volvería Reviewed on Jan 19, 2026 [](https://expedia.com/Hotel-Search?startDate=2%2F16%2F2026&endDate=2%2F17%2F2026&selected=91818768&PinnedHotelID=91818768&HadPinnedHotel=true®ionId=553248635975847775) ![Barceló Guatemala City](https://images.trvl-media.com/lodging/1000000/10000/2500/2495/78fae458_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Barceló Guatemala City 7 Avenida 15-45, Zona 9 Guatemala City Guatemala $89 nightly $108 total Mar 2 - Mar 3 Total with taxes and fees Book a stay at this luxury hotel in Guatemala City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the breakfast and the pool in our ... 9/10 Wonderful! (3,195 reviews) Clean, spacious Reviewed on Feb 12, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F2%2F2026&endDate=3%2F3%2F2026&selected=2495&PinnedHotelID=2495&HadPinnedHotel=true®ionId=553248635975847775) ![Porta Hotel Antigua](https://images.trvl-media.com/lodging/1000000/10000/5600/5545/b3d7f8e6_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Porta Hotel Antigua 8va Calle Poniente No1 Antigua Guatemala Sacatepequez $185 nightly $226 total Mar 3 - Mar 4 Total with taxes and fees Book a stay at this luxury hotel in Antigua Guatemala. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the clean ... 9.2/10 Wonderful! (1,001 reviews) Lovely Reviewed on Feb 9, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F3%2F2026&endDate=3%2F4%2F2026&selected=5545&PinnedHotelID=5545&HadPinnedHotel=true®ionId=553248635975847775) ![Hotel Museo Spa Casa Santo Domingo](https://images.trvl-media.com/lodging/2000000/1250000/1246600/1246555/20929971_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hotel Museo Spa Casa Santo Domingo 3a Calle Oriente No 28 A Antigua Guatemala Sacatepequez $276 nightly $337 total Feb 24 - Feb 25 Total with taxes and fees Book a stay at this luxury hotel in Antigua Guatemala. Enjoy free parking, a full-service spa, and 2 restaurants. Our guests praise the helpful staff and the ... 9.2/10 Wonderful! (1,040 reviews) Absolutely outstanding place. Loved it Reviewed on Feb 8, 2026 [](https://expedia.com/Hotel-Search?startDate=2%2F24%2F2026&endDate=2%2F25%2F2026&selected=1246555&PinnedHotelID=1246555&HadPinnedHotel=true®ionId=553248635975847775) ![Wyndham Garden Guatemala City](https://images.trvl-media.com/lodging/1000000/30000/26600/26567/449c3cd0_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Wyndham Garden Guatemala City 1a Avenida 12-46 Zona 10 Guatemala City Guatemala $92 nightly $112 total Mar 15 - Mar 16 Total with taxes and fees Book a stay at this business-friendly hotel in Guatemala City. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful ... 9/10 Wonderful! (1,685 reviews) Excellent staff Reviewed on Feb 5, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F15%2F2026&endDate=3%2F16%2F2026&selected=26567&PinnedHotelID=26567&HadPinnedHotel=true®ionId=553248635975847775) ![Hotel Camino Real Antigua](https://images.trvl-media.com/lodging/4000000/3090000/3085000/3084914/17346378_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hotel Camino Real Antigua 7a Calle Poniente 33B Antigua Guatemala Sacatepequez $186 nightly $232 total Feb 23 - Feb 24 Total with taxes and fees Book a stay at this spa hotel in Antigua Guatemala. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the property ... 9.6/10 Exceptional! (1,000 reviews) Good Reviewed on Feb 8, 2026 [](https://expedia.com/Hotel-Search?startDate=2%2F23%2F2026&endDate=2%2F24%2F2026&selected=3084914&PinnedHotelID=3084914&HadPinnedHotel=true®ionId=553248635975847775) [See all 1,183 properties in Santa Ana](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=2%2F15%2F2026&endDate=2%2F16%2F2026®ionId=553248635975847775) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=DX-NH_SPRING_PROMO_553248635975847775) ## Check Santa Ana hotel availability [Tonight ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635975847775&startDate=2026-02-14&endDate=2026-02-15)[Feb 14 - Feb 15](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635975847775&startDate=2026-02-14&endDate=2026-02-15) [Tomorrow night ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635975847775&startDate=2026-02-15&endDate=2026-02-16)[Feb 15 - Feb 16](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635975847775&startDate=2026-02-15&endDate=2026-02-16) [Next weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635975847775&startDate=2%2F20%2F2026&endDate=2%2F22%2F2026)[Feb 20 - Feb 22](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635975847775&startDate=2%2F20%2F2026&endDate=2%2F22%2F2026) --- ### Other neighborhoods around Santa Ana ![Cross and Volcan de Agua View From Cerro de la Cruz, Antigua, Sacatepequez Department, Guatemala](https://images.trvl-media.com/place/911356092010033152/29d5145e-703b-47ae-817d-6e4cfbcb485c.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Barrio de La Concepción While visiting Barrio de La Concepción, you might make a stop by sights like Casa Santo Domingo Museum and Jade Maya Factory and Museum. [](https://expedia.com/Antigua-Guatemala-Barrio-De-La-Concepcion.dx911356092010033152) ![Vue du volcan de Fuego](https://images.trvl-media.com/place/180589/dca320f5-d6f0-40d9-9f12-90c9c1ede687.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Historic Center While visiting Historic Center, you might make a stop by sights like Central Park and Santa Catalina Arch. [](https://expedia.com/Antigua-Guatemala-Historic-Center.dx911355684795535360) [See our Where To Stay guide](https://expedia.com/Antigua-Guatemala.dx180589.Where-To-Stay?rfrr=TG.LP.Dest.Neigh.Neighborhoods) --- --- - [Stays](?pwaLob=wizard-hotel-pwa-v2) - [Packages](?pwaLob=wizard-package-pwa) - [Flights](?pwaLob=wizard-flight-pwa) - [Things to do](?pwaLob=wizard-lx-pwa) - [Cruises](?pwaLob=wizard-cruise-pwa) - [Cars](?pwaLob=wizard-car-pwa) # Santa Ana ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save even more - get up to 20% on select hotels when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app