Santa Fe de Antioquia

Travel Guide

A historic fountain with water jets, surrounded by lush greenery and a white church with a bell tower in the background.
A street with buildings, a motorcycle, a tricycle, and a mountain in the background.
A vintage-themed living room with a large arched wall, a vintage camera, a red armchair, a wooden cabinet, and a large black and white portrait.
A colorful bus with 'La Santafrenia' written on it parked in front of a building with a tiled roof.
A white tuk-tuk parked on a cobblestone street in a historic town.

Where to stay in Santa Fe de Antioquia

Find the best Santa Fe de Antioquia areas and neighborhoods for the activities you enjoy most. Learn more about Santa Fe de Antioquia
Learn more about Santa Fe de Antioquia
A historic fountain with water jets, surrounded by lush greenery and a white church with a bell tower in the background.
Photo by Tahino2000
Open Photo by Tahino2000

Zona Colonial

If you're spending some time in Zona Colonial, Bolivar Square and Cathedral of Santa Fe de Antioquia are top sights worth seeing.

Arde La Selva

Arde La Selva

4 out of 5
km 1 via anza vereda obregon Santa Fe de Antioquia Antioquia
$164 nightly
The price is $164 total per night from Oct 4 to Oct 5
$164 total
Oct 4 - Oct 5
Stay at this hotel in Santa Fe de Antioquia. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Museo Juan del Corral and Bolivar Square ...
Arde La Selva
Ivanna Hotel Campestre - Santa Fe de Antioquia

Ivanna Hotel Campestre - Santa Fe de Antioquia

4.5 out of 5
Via Anza Vereda, KM 1, Obregon Santa Fe de Antioquia Antioquia
$64 nightly
The price is $64 total per night from Oct 2 to Oct 3
$64 total
Oct 2 - Oct 3
Book a stay at this luxury hotel in Santa Fe de Antioquia. Enjoy free breakfast, free WiFi, and 2 outdoor pools. Popular attractions Museo Juan del Corral and ...
7.2/10 Good! (10 reviews)
"Amazing staff, Swimming pool and spa Hot tub Wonderful area secluded Relaxing atmosphere with all the amenities"

Reviewed on Aug 30, 2026

Ivanna Hotel Campestre - Santa Fe de Antioquia
Hotel campestre real

Hotel campestre real

3 out of 5
kilometro 70 via el mar vereda el paso real Santa Fe de Antioquia Antioquia
$54 nightly
The price is $54 total per night from Oct 1 to Oct 2
$54 total
Oct 1 - Oct 2
Book a stay at this family-friendly hotel in Santa Fe de Antioquia. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Museo Juan del Corral ...
10/10 Exceptional! (1 review)
"Great location near downtown. Quiet area with a nice pool"

Reviewed on May 6, 2026

Hotel campestre real
See all 522 properties in Santa Fe de Antioquia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Finca hotel mi refugio

Finca hotel mi refugio

2 out of 5
1541 Camino real Santa Fé de Antioquia Antioquia
Stay at this cottage in Santa Fe de Antioquia. Enjoy free WiFi, free parking, and a garden. Popular attractions Museo Juan del Corral and Bolivar Square are ...
Finca hotel mi refugio
Villa in historic center with private pool for 9 people

Villa in historic center with private pool for 9 people

Santa Fé de Antioquia Antioquia
Stay at this villa in Santa Fe de Antioquia. Enjoy air conditioning. Popular attractions Casa Atanasio Girardot and Cathedral of Santa Fe de Antioquia are located ...
Villa in historic center with private pool for 9 people
SANTA FE DE ANTIOQUIA

SANTA FE DE ANTIOQUIA

2 out of 5
111 Cl. 8 Santa Fe de Antioquia Antioquia
Stay at this aparthotel in Santa Fe de Antioquia. Enjoy free WiFi, 6 outdoor pools, and a garden. Popular attractions Bolivar Square and Cathedral of Santa Fe ...
8/10 Very Good! (1 review)
"Todo Ok"

Reviewed on Feb 10, 2025

SANTA FE DE ANTIOQUIA
See all properties in Santa Fe de Antioquia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Santa Fe de Antioquia attractions

Cathedral of Santa Fe de Antioquia

9.0/10 (28 reviews)
You can learn about the history of Santa Fe de Antioquia with a trip to Cathedral of Santa Fe de Antioquia. Make time to visit the monuments and cathedral while you're in the area.
See properties

Things to do

Tour Santa Fe de Antioquia

Tour Santa Fe de Antioquia

$150
per adult
Tour Santa Fe de Antioquia
Santa Fe de Antioquia Tour with Western Bridge Visit

Santa Fe de Antioquia Tour with Western Bridge Visit

$55
per adult
Santa Fe de Antioquia Tour with Western Bridge Visit
Private Coffee & Panel Tour Near Medellin All Inclusive

Private Coffee & Panel Tour Near Medellin All Inclusive

$150
per adult
Private Coffee & Panel Tour Near Medellin All Inclusive
See all activities in Santa Fe de Antioquia

Frequently asked questions

Is Santa Fe de Antioquia worth visiting?
Santa Fe de Antioquia is worth visiting for its historical attractions, including the impressive Bridge of the West and the central Bolivar Square. Travelers can also explore the distinct Zona Colonial, which offers a rich sense of the city's past and unique character.
Where are the best neighborhoods to explore in Santa Fe de Antioquia?
The best neighborhoods to explore in Santa Fe de Antioquia depend on what you want to see:


What is Santa Fe de Antioquia known for?
Santa Fe de Antioquia is known for its nickname 'CIUDAD MADRE' and its historical landmarks. Travelers can explore the iconic Bridge of the West, Bolivar Square, and Museo Juan del Corral. This riverside city sits on the Cauca River, offering a glimpse into its rich heritage.
What is a good itinerary length for Santa Fe de Antioquia?
A good itinerary length for Santa Fe de Antioquia is one to two days to explore highlights like the Bridge of the West, Bolivar Square, and Museo Juan del Corral, and experience the Zona Colonial. An extended stay of three to four days allows travelers to delve deeper into the Colonial Town and enjoy a Santa Fe de Antioquia and Coffee Sightseeing Tour. See Santa Fe de Antioquia Activities.
What are the top things to do in and around Santa Fe de Antioquia?
Santa Fe de Antioquia offers a journey into colonial history, with historic landmarks and charming town squares:


How do I plan a trip to Santa Fe de Antioquia?
To plan your trip to Santa Fe de Antioquia, search Expedia for places to stay and book your flights in advance. Focus on the Zona Colonial to explore landmarks like Museo Juan del Corral and Bolivar Square. Consider booking a tour, such as a private colonial secrets tour or a coffee sightseeing tour, to enhance your visit.
Can I book a refundable hotel in Santa Fe de Antioquia?
Yes, Expedia offers many flexible booking options, and you can look for refundable hotels in Santa Fe de Antioquia by entering your dates and using the refundable or fully refundable filter. Always check the hotel's cancellation policy before you book, since terms can vary by hotel, and visit Expedia help center for further details.
Why book a trip to Santa Fe de Antioquia with Expedia?
Expedia makes it easier to plan your Santa Fe de Antioquia trip with travel tools, flexible search options, and bookable trip components all in one place. You can organize your plans in one account and use Expedia to help build a trip that fits your budget and travel style. Find out more about how by visiting Expedia's Trip Planner page.
Should I stay in a hotel or vacation rental in Santa Fe de Antioquia?
The best choice depends on your travel style. Hotels in Santa Fe de Antioquia can be a good fit for convenience, on-site amenities, and shorter stays, while vacation rentals may offer more space, privacy, and home-style amenities for longer trips, families, or groups. With Expedia, you can compare both options side by side, read traveler reviews, and filter by amenities to find the right fit for your trip.
How can I manage my Santa Fe de Antioquia trip on Expedia?
Once you've booked your Santa Fe de Antioquia trip, you can manage it through your Expedia account or the Expedia app. You can view your itinerary, access booking details, make eligible changes, and check for updates in My Trips. The Expedia app can also help you stay organized while you travel.
What if I need help during my Santa Fe de Antioquia trip?
Expedia offers customer support before, during, and after your Santa Fe de Antioquia trip. If your plans change or something unexpected happens, you can review your booking in My Trips and use Expedia help center channels for help with eligible changes, cancellations, or travel issues.
How can Expedia help me plan my first trip to Santa Fe de Antioquia?
If it's your first trip to Santa Fe de Antioquia, Expedia can help you plan by bringing together stays, flights, activities, traveler reviews, and trip-planning tools in one place. With Expedia's Trip Planner you can compare options, read reviews from other travelers, and build an itinerary that matches your interests and budget.
How can I save on my Santa Fe de Antioquia hotel booking with Expedia?
Join One Key™ for free to unlock instant discounts with Member Prices on select hotels. You can also earn and use OneKeyCash™* on eligible bookings on Expedia. Booking in advance is usually another great way to save on your Santa Fe de Antioquia hotel.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.

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