Downtown, SC
Seneca
Visit Downtown
Stay near popular Downtown attractions
Downtown Hotel Deals
Quality Inn Seneca Clemson Area US-123
226 Hi Tech Rd Seneca SC
Fully refundable
$90 nightly
The price is $98 total per night from Jul 24 to Jul 25
$98 total
Jul 24 - Jul 25
Total with taxes and fees
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
Best Western Plus Clemson Hotel & Conference Center
1310 Tiger Blvd Clemson SC
$101 nightly
The price is $112 total per night from Jul 20 to Jul 21
$112 total
Jul 20 - Jul 21
Total with taxes and fees
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
The Shepherd Hotel Downtown Clemson
110 Sloan St Clemson SC
$155 nightly
The price is $173 total per night from Jul 27 to Jul 28
$173 total
Jul 27 - Jul 28
Total with taxes and fees
Stay at this hotel in Clemson. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the clean rooms in our reviews. ...
Days Inn by Wyndham Anderson
1007 George Smith Mill Rd Anderson SC
$59 nightly
The price is $65 total per night from Jul 20 to Jul 21
$65 total
Jul 20 - Jul 21
Total with taxes and fees
Book a stay at this business-friendly motel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8/10 Very Good! (1,002 reviews)
"We stayed in the new building, it was clean and nice, and our room was very spacious. Great room. Cleaning ladies were very friendly. Breakfast could have been a little better, it did have some of the usual stuff (waffles, packages of oatmeal and grits, packages of pastries, coffee, etc.), but no ..."
Reviewed on Jul 17, 2026
Lakeside Lodge Clemson
13500 Clemson Blvd Seneca SC
$123 nightly
The price is $135 total per night from Jul 19 to Jul 20
$135 total
Jul 19 - Jul 20
Total with taxes and fees
Stay at this hotel in Seneca. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
9/10 Wonderful! (1,001 reviews)
"Nice place."
Reviewed on Jul 17, 2026
Courtyard Marriott Clemson
201 Canoy Ln Clemson SC
$134 nightly
The price is $149 total per night from Aug 2 to Aug 3
$149 total
Aug 2 - Aug 3
Total with taxes and fees
Book a stay at this business-friendly hotel in Clemson. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Memorial Stadium and Clemson ...
9/10 Wonderful! (552 reviews)
"The room was great! Staff was extremely polite and helpful. Unfortunately the cost for a night during and event in town, the room was priced 4x's the regular rate, that's my only complaint."
Reviewed on Jun 29, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Downtown
Find the best Downtown areas and neighborhoods for the activities you enjoy most.
Serenity Bay
Though Serenity Bay might not have many top sights, you can venture to the surrounding area to see attractions like Keowee Key Golf Course and Lake Keowee.
Pine Ridge Point
While Pine Ridge Point isn't home to many top sights, South Beach and Lake Keowee are some notable places to visit nearby.
Indian Oaks
While there might not be top attractions in Indian Oaks, you can explore the larger area and discover places like Oconee County Library Seneca Branch and Keowee Reservoir.
Keowee Plantation
When in Keowee Plantation, you can plan a visit to Oconee County Library Seneca Branch and Keowee Reservoir, some noteworthy sights in the nearby area.
