Find hotels in Seneca, MD from $85

The best area to stay in Seneca, Maryland, is near the Great Falls of the Potomac or along the C&O Canal for convenient access to outdoor activities.For couples or solo travelers seeking a tranquil experience surrounded by nature, staying close to the Great Falls area offers a serene escape. This location provides immediate access to the Great Falls Park, where you can explore various hiking trails, enjoy picturesque overlooks of the falls, and observe local wildlife. The area is characterized by its natural beauty and opportunities for quiet reflection.Families looking for a blend of outdoor adventure and educational opportunities will appreciate accommodations near the C&O Canal National Historical Park. This area offers easy access to the canal towpath, superb for biking or walking, and provides insights into the region's history with features like historic locks and visitor centers.

With Expedia, you earn OneKeyCash™* on eligible Seneca hotel bookings for every dollar you spend – just join our One Key™ travel rewards program to get started. It's free to join, and you'll unlock our lowest Member Prices as soon as you're signed in. On top of this, you could also save significantly by bundling your hotel and flights together on Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.