St. Charles Vacation Rentals

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Our top choices for St. Charles vacation rentals

St. Charles Manor | 2BR Hot Tub Chalet | 1.2 Acres

St. Charles Manor | 2BR Hot Tub Chalet | 1.2 Acres
Saint Charles
8.8 out of 10, Excellent, (3 reviews)
"We loved the location for our travel needs and we had everything we needed for a family of two adults and two dogs. "
United States
Leslie R.
$494 nightly
The price is $557
May 7 - May 8
Total with taxes and fees
St. Charles Manor | 2BR Hot Tub Chalet | 1.2 Acres

St. Charles Manor | 4BR Getaway Home+HotTub+GameRm .6 acres

St. Charles Manor | 4BR Getaway Home+HotTub+GameRm .6 acres
Saint Charles
10.0 out of 10, Exceptional, (5 reviews)
"Wonderful place to stay for a group trip! Lots of space and activities for everyone to do. The hosts are very accommodating and quick to respond for any last minute questions. "
United States
Scott S.
$679 nightly
The price is $754
May 10 - May 11
Total with taxes and fees
St. Charles Manor | 4BR Getaway Home+HotTub+GameRm .6 acres

Charming open 4bd and screen-in porch! Sleeps 10!

Charming open 4bd and screen-in porch! Sleeps 10!
Saint Charles
9.2 out of 10, Wonderful, (38 reviews)
"House had everything we needed, and was very well organized! Would definitely recommend!"
United States
Tim W.
$443 nightly
The price is $501
May 7 - May 8
Total with taxes and fees
Charming open 4bd and screen-in porch! Sleeps 10!

Walk to St. Charles Entertainment

Walk to St. Charles Entertainment
Saint Charles
9.0 out of 10, Wonderful, (10 reviews)
"We really enjoyed our stay. The house was clean, spacious, and very accommodating. We stayed for a dance competition and the proximity to the convention center was unbeatable. "
United States
Chloe
$264 nightly
The price is $291
May 10 - May 11
Total with taxes and fees
Walk to St. Charles Entertainment

St. Charles Manor | 4BR Reunion Home+HotTub+GameRm .67 acres

St. Charles Manor | 4BR Reunion Home+HotTub+GameRm .67 acres
Saint Charles
10.0 out of 10, Exceptional, (1 review)
"Such a perfect place to stay for a weekend with a larger group! Close to a lot of different things and had pretty much everything you could need. It was also super clean and nice! "
United States
Amanda P.
$833 nightly
The price is $934
May 7 - May 8
Total with taxes and fees
St. Charles Manor | 4BR Reunion Home+HotTub+GameRm .67 acres

The Brick & Beam 3rd Floor Apartment

The Brick & Beam 3rd Floor Apartment
St. Charles Historic District
$285 nightly
The price is $314
May 7 - May 8
Total with taxes and fees
The Brick & Beam 3rd Floor Apartment

New Remodel in St. Charles - Sleeps 10! New patio! Large Fenced-in backyard!

New Remodel in St. Charles - Sleeps 10! New patio! Large Fenced-in backyard!
St. Charles Historic District
9.6 out of 10, Exceptional, (71 reviews)
"Very clean and comfortable. Enjoyed our stay"
United States
Dana S.
$431 nightly
The price is $487
May 11 - May 12
Total with taxes and fees
New Remodel in St. Charles - Sleeps 10! New patio! Large Fenced-in backyard!

The Lofts of North Main Street

The Lofts of North Main Street
St. Charles Historic District
9.6 out of 10, Exceptional, (169 reviews)
"Host was very responsive and location was perfect"
United States
Peggy K.
$240 nightly
The price is $257
May 7 - May 8
Total with taxes and fees
The Lofts of North Main Street

Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!

Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!
St. Charles Historic District
9.6 out of 10, Exceptional, (75 reviews)
"Great communication from host, cute house in an awesome location. Will definitely be staying again!"
United States
Sydney W.
$230 nightly
The price is $246
May 10 - May 11
Total with taxes and fees
Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!

Historic 1908 Frenchtown Home

Historic 1908 Frenchtown Home
St. Charles Historic District
8.6 out of 10, Excellent, (20 reviews)
"Very clean, older 2-bedroom home. Close to all the Main Street action. House had all the amenities we needed."
United States
Michele S.
$265 nightly
The price is $292
May 7 - May 8
Total with taxes and fees
Historic 1908 Frenchtown Home

Spacious, Beautiful St. Charles Home-Remodeled-Sleeps 10! New Patio!

Spacious, Beautiful St. Charles Home-Remodeled-Sleeps 10! New Patio!
St. Charles Historic District
9.8 out of 10, Exceptional, (61 reviews)
"We enjoyed our stay in St Charles. Amazingly clean and very close to st Charles downtown. "
United States
JonandBeth T.
Spacious, Beautiful St. Charles Home-Remodeled-Sleeps 10! New Patio!

Main Street Balcony Apartment

Main Street Balcony Apartment
St. Charles Historic District
9.6 out of 10, Exceptional, (36 reviews)
"Great location for shopping and a lot of restaurants nearby. Beds were very comfortable. "
United States
Brooke I.
$394 nightly
The price is $434
May 10 - May 11
Total with taxes and fees
Main Street Balcony Apartment

Historic Main St. Customs House Upstairs Apartment

Historic Main St. Customs House Upstairs Apartment
St. Charles Historic District
9.6 out of 10, Exceptional, (37 reviews)
"Great Stay and great location! "
United States
Angela
$318 nightly
The price is $351
May 7 - May 8
Total with taxes and fees
Historic Main St. Customs House Upstairs Apartment

Amazing Renovated Historic Loft on Main Street

Amazing Renovated Historic Loft on Main Street
St. Charles Historic District
10.0 out of 10, Exceptional, (59 reviews)
"Lovely accommodations, very clean, well equipped, great location. "
United States
Emily B.
$259 nightly
The price is $277
May 11 - May 12
Total with taxes and fees
Amazing Renovated Historic Loft on Main Street

Home Near Main Street-Covered Patio-Hot Tub!

Home Near Main Street-Covered Patio-Hot Tub!
Saint Charles
9.6 out of 10, Exceptional, (32 reviews)
"Great house and great location"
United States
Mike L.
$443 nightly
The price is $501
May 7 - May 8
Total with taxes and fees
Home Near Main Street-Covered Patio-Hot Tub!

Spacious 2 Bedroom Townhome

Spacious 2 Bedroom Townhome
Saint Charles
8.0 out of 10, Very Good, (14 reviews)
"The stay here was amazing!! Live the little townhouse so much. Host was amazing!!"
United States
Tina W.
$256 nightly
The price is $282
May 7 - May 8
Total with taxes and fees
Spacious 2 Bedroom Townhome

Music House · Music House on Main Street at The Wine Garden

Music House · Music House on Main Street at The Wine Garden
Saint Charles
9.2 out of 10, Wonderful, (15 reviews)
"Nice area nice place and communication"
United States
Zack P.
$800 nightly
The price is $898
May 7 - May 8
Total with taxes and fees
Music House · Music House on Main Street at The Wine Garden

The Historic Bricks on Main

The Historic Bricks on Main
St. Charles Historic District
9.0 out of 10, Wonderful, (17 reviews)
"Had a wonderful stay. Host was very responsive. Great stay in the middle of everything- so we could walk out and shop or grab a bite to eat. "
United States
Alison C.
$209 nightly
The price is $230
May 10 - May 11
Total with taxes and fees
The Historic Bricks on Main

Cottage on Historic Main Street- Low Cleaning fee

Cottage on Historic Main Street- Low Cleaning fee
St. Charles Historic District
10.0 out of 10, Exceptional, (14 reviews)
"A very quiet, clean and relaxing stay. "
United States
Dora S.
$275 nightly
The price is $294
May 12 - May 13
Total with taxes and fees
Cottage on Historic Main Street- Low Cleaning fee

Prime Loft of Main Street

Prime Loft of Main Street
St. Charles Historic District
9.8 out of 10, Exceptional, (110 reviews)
"This was a wonderful place for our St Charles stay - right in the heart of the historic downtown. Very clean and with nice character (exposed brick walls, tastefully decorated, etc). We had plenty of room fo the three of us, and our almost 12 year old kiddo LOVED having the loft upstairs to herself. If you are looking for a place to stay outside of St Louis, I highly recommend this location."
United States
Julie
$255 nightly
The price is $273
May 7 - May 8
Total with taxes and fees
Prime Loft of Main Street
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top St. Charles Hotel Reviews

Find out more about St. Charles

Everything you need to know about St. Charles vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the St. Charles vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect St. Charles vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

St. Charles vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in St. Charles. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit St. Charles in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $136 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on St. Charles rentals

At Expedia, we put the best St. Charles vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top St. Charles rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream St. Charles vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around St. Charles. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently asked questions

Can I find vacation rentals in St. Charles?

Yes, you can find vacation rentals near popular attractions in St. Charles, or you can choose a secluded option if you're looking for relaxation. Tourists like the array of shops and top-notch restaurants in St. Charles. The live music and theater scene are some other things you might like to check out during your trip.

What are some of the best vacation rentals that St. Charles has to offer?

St. Charles 1860's Gem - Sleeps 6!: This highly rated vacation home rental in St. Charles is located on a river and has a garden, a selection of books, and air-conditioning to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop.

How many vacation rentals are there in St. Charles?

Expedia has 82 vacation rentals for your stay in St. Charles.

What can I see and do in St. Charles?

Katy Trail and Mississippi River are a couple of scenic spots to enjoy the outdoors, whereas Missouri Artists on Main is one of the cultural attractions. Other places in town to visit include Historic Main Street and Lewis & Clark Boathouse and Nature Center.

What are vacation rentals like in St. Charles?

Vacation rentals are privately owned accommodations you can book for several days or more in St. Charles. Vacation rentals provide amenities such as laundry facilities and kitchens to help you enjoy your stay. If you're concerned about a clean environment, vacation rentals can offer a sense of privacy away from shared hotel elevators and lobbies packed with people while still allowing you the enjoyment of travel. You'll also have more space in a vacation rental than in a hotel, which makes a vacation rental an attractive option for a family getaway.