Title: Visit Wyatt: 2026 Travel Guide for Wyatt, Missouri | Expedia.com [Hotels in Wyatt](https://expedia.com/Wyatt-Hotels.d553248634983534991.Travel-Guide-Hotels)[Vacation Rentals in Wyatt](https://expedia.com/Wyatt-Vacation-Rentals.d553248634983534991.Travel-Guide-VacationRentals)[Car Rentals in Wyatt](https://expedia.com/Car-Rentals-In-Wyatt.d553248634983534991.Car-Rental-Guide)[Wyatt Vacation Packages](https://expedia.com/Wyatt.d553248634983534991.Destination-Travel-Guides) # Wyatt, MO ## Travel Guide ## Visit Wyatt ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=DX_SPRING_PROMO_553248634983534991) - Wyatt Hotel Deals - Vacation Rentals in Wyatt ![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Drury Inn & Suites Sikeston, MO 2608 East Malone Ave, Miner Sikeston MO $94 nightly $108 total Mar 10 - Mar 11 Total with taxes and fees Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ... 9.4/10 Exceptional! (1,009 reviews) Plenty of good parking. Good food choices nearby. Very comfortable rooms Reviewed on Mar 4, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F10%2F2026&endDate=3%2F11%2F2026&selected=24210&PinnedHotelID=24210&HadPinnedHotel=true®ionId=553248634983534991) ![Best Western Plus Sikeston I-55](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Best Western Plus Sikeston I-55 120 S Interstate Drive Sikeston MO Fully refundableReserve now, pay when you stay $82 nightly $93 total Mar 26 - Mar 27 Total with taxes and fees Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ... 8.4/10 Very Good! (1,005 reviews) We started our stay with a hostile guest while trying to check in. The lack of care from the worker at check in was a new level of IDGAF, the following day they turned our Reviewed on Mar 2, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F26%2F2026&endDate=3%2F27%2F2026&selected=8420572&PinnedHotelID=8420572&HadPinnedHotel=true®ionId=553248634983534991) ![Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/47690ac7_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) 100 Matthews Lane Sikeston MO $67 nightly $76 total Apr 1 - Apr 2 Total with taxes and fees Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ... 8.4/10 Very Good! (748 reviews) The room was clean and comfortable. Check in staff was friendly. Reviewed on Mar 5, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F1%2F2026&endDate=4%2F2%2F2026&selected=34745&PinnedHotelID=34745&HadPinnedHotel=true®ionId=553248634983534991) [See all 21 properties in Wyatt](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=3%2F7%2F2026&endDate=3%2F8%2F2026®ionId=553248634983534991) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![Cozy cabins on beautiful Horseshoe Lake](https://images.trvl-media.com/lodging/91000000/90340000/90331200/90331191/53db6388_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Cozy cabins on beautiful Horseshoe Lake Olive Branch IL Stay at this cabin in Alexander County. Enjoy patios, an in-room coffeemaker, and air conditioning. 9.8/10 Exceptional! (37 reviews) The cabin was extremely clean and nice. Amenities were perfect. Right by the lake. Would highly recommend. Reviewed on Feb 28, 2026 [](https://expedia.com/Cozy-Cabins-On-Beautiful-Horseshoe-Lake.h90331191.Hotel-Information) ![Peaceful secluded cabin located near Horseshoe Lake ](https://images.trvl-media.com/lodging/110000000/109740000/109730100/109730068/1be40475_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Peaceful secluded cabin located near Horseshoe Lake Miller City IL Stay at this cabin in Alexander County. Enjoy an in-room coffeemaker and air conditioning. 10/10 Exceptional! (21 reviews) The place was quiet, clean and secluded. Exactly what my wife and I were looking for. Thanks for having us! Reviewed on Feb 9, 2026 [](https://expedia.com/Peaceful-Secluded-Cabin-Located-Near-Horseshoe-Lake.h109730068.Hotel-Information) ![The Rested Duck Mallard Room](https://images.trvl-media.com/lodging/91000000/90340000/90331100/90331048/d70c82b7_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### The Rested Duck Mallard Room Olive Branch IL Stay at this cabin in Alexander County. Enjoy air conditioning. [](https://expedia.com/The-Rested-Duck-Mallard-Room.h90331048.Hotel-Information) [See all properties in Wyatt](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience®ionId=553248634983534991&sort=VACATION_RENTAL) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check Wyatt hotel availability [Tonight ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634983534991&startDate=2026-03-06&endDate=2026-03-07)[Mar 6 - Mar 7](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634983534991&startDate=2026-03-06&endDate=2026-03-07) [Tomorrow night ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634983534991&startDate=2026-03-07&endDate=2026-03-08)[Mar 7 - Mar 8](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634983534991&startDate=2026-03-07&endDate=2026-03-08) [This weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634983534991&startDate=3%2F6%2F2026&endDate=3%2F8%2F2026)[Mar 6 - Mar 8](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634983534991&startDate=3%2F6%2F2026&endDate=3%2F8%2F2026) ## Cities near Wyatt ![Cypress Trees on the Horizon. A sting of cypress trees of various sizes extend across the horizon as the sunken sun paints the multicolored sky. ](https://images.trvl-media.com/place/7182/2c4b1a06-d3aa-4171-b8b6-0e4eaaa0e80e.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Charleston - Cities near Wyatt - Places of interest [Charleston](https://expedia.com/Charleston.dx7182) - [Shawnee National Forest ](https://expedia.com/Shawnee-National-Forest-Illinois.d553248635944113522.Vacation-Attraction) - [Mississippi River ](https://expedia.com/Mississippi-River-United-States-of-America.d6209928.Vacation-Attraction) - [Ohio River ](https://expedia.com/Ohio-River-United-States-of-America.d681940626945888256.Vacation-Attraction) - [Ohio River Valley ](https://expedia.com/Ohio-River-Valley-United-States-of-America.d6233674.Vacation-Attraction) - [Columbus-Belmont State Park ](https://expedia.com/Columbus-Belmont-State-Park-Columbus.d6091579.Vacation-Attraction) - [Mound City National Cemetery ](https://expedia.com/Mound-City-National-Cemetery-Mound-City.d553248621555594730.Vacation-Attraction) - [Fort Defiance State Park ](https://expedia.com/Fort-Defiance-State-Park-Cairo.d6091411.Vacation-Attraction) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save even more - get up to 20% on select hotels when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. 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