$149 Cheap American Airlines flights Des Moines (DSM) to New York (LGA)

Scoring cheap one-way American Airlines flights from DSM to LGA from $149 on Expedia is simple --- just filter by "Price (lowest to highest)." Alternatively, check out our affordable round-trip fares from $283 for your next exciting getaway.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Begin your search one to three months ahead of your travel date to score cheaper fares on American Airlines flights from Des Moines Intl. Airport (DSM) to LaGuardia Airport (LGA). You can save 25% by booking your domestic flight 34 to 86 days in advance compared to last-minute reservations made 6 to 12 days out. You could also reduce costs by buying your fare on a Sunday, as it's 6% cheaper on average than a Monday, the most expensive day to book.* Time it well, and you can enjoy significant savings on domestic journeys.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Jetting off from DSM at 7:30AM UTC-6, the earliest American Airlines flight to LGA lands at 11:09AM UTC-5. Flying earlier in the day means you'll be less likely to experience delays.* Not a morning person? The last American Airlines flight from DSM to LGA departs at 7:30AM UTC-6 and touches down at 11:09AM UTC-5.*Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.