Uptown - Upper Duval, FL

Key West

Key West Butterfly and Nature Conservatory featuring zoo animals, animals and flowers
Key West Butterfly and Nature Conservatory showing zoo animals, animals and flowers
South Beach which includes a beach and a coastal town as well as a large group of people
South Beach showing a beach, swimming and a luxury hotel or resort
Key West Butterfly and Nature Conservatory featuring signage

Popular places to visit

Southernmost Point featuring signage as well as a large group of people

Southernmost Point

4.5/5(3,182 reviews)

Snap a memorable photograph from the edge of North America at this monumental landmark.

Southernmost Point
South Beach featuring a sandy beach and general coastal views as well as a small group of people

South Beach

4/5(980 reviews)

Head to the southernmost beach of the continental United States to relax and swim in the waters where famous writer Tennessee Williams once took his daily swim.

South Beach
Key West Butterfly and Nature Conservatory showing animals, zoo animals and food

Key West Butterfly and Nature Conservatory

4.5/5(760 reviews)

With about 60 species of butterfly, an indoor waterfall and a tropical rainforest, this nature conservatory is one of the most popular attractions in Key West.

Key West Butterfly and Nature Conservatory

Things to do

Florida: Key West Overseas Highway Self-Driving Tour

Florida: Key West Overseas Highway App-Based Driving Audio Tour

$17
per traveler
78% of travellers recommend
Florida: Key West Overseas Highway App-Based Driving Audio Tour
Bahama Village Walking Tour

Bahama Village Walking Tour

$30
per adult
Bahama Village Walking Tour
Key West’s Old Town Treasures: A Self-Guided Audio Tour

Key West’s Old Town Treasures: A Self-Guided Audio Tour

$15
per adult
Key West’s Old Town Treasures: A Self-Guided Audio Tour
Florida Key West Self-Guided Walking Audio Tour

Florida Key West Self-Guided Walking Audio Tour Via App

$10
per traveler
Florida Key West Self-Guided Walking Audio Tour Via App
Climb the 88 stairs to the top of the Key West Lighthouse.

Maritime Village to Micro State: A Self Guided Tour of Key West

$12
per adult
Maritime Village to Micro State: A Self Guided Tour of Key West
An Audio Guide of Key West’s Journey From Village to Micro State

An Audio Guide of Key West’s Journey From Village to Micro State

$12
per adult
An Audio Guide of Key West’s Journey From Village to Micro State
See all activities in Key West

Uptown - Upper Duval Hotel Deals

Southernmost Beach Resort and Guesthouses
Southernmost Beach Resort and Guesthouses
4 out of 5
1319 Duval Street, Key West, FL
$259 nightly
The price is $291 total per night from Aug 4 to Aug 5
$291 total
Aug 4 - Aug 5
Total includes taxes and fees
Stay at this 4-star beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the bar in our reviews. ...
8.6/10 Excellent! (2,625 reviews)
"Clean, friendliest front desk people."

Reviewed on Jul 13, 2025

Southernmost Beach Resort and Guesthouses
The Reach Key West, Curio Collection by Hilton
The Reach Key West, Curio Collection by Hilton
4 out of 5
1435 Simonton Street, Key West, FL
$291 nightly
The price is $327 total per night from Aug 11 to Aug 12
$327 total
Aug 11 - Aug 12
Total includes taxes and fees
Stay at this 4-star beach resort in Key West. Enjoy a full-service spa, a private beach, and breakfast (surcharge). Our guests praise the helpful staff and the ...
8.2/10 Very Good! (1,013 reviews)
"Staff was very pleasant"

Reviewed on Jul 12, 2025

The Reach Key West, Curio Collection by Hilton
The Southernmost Inn - Adults Only
The Southernmost Inn - Adults Only
3 out of 5
525 United Street, Key West, FL
$153 nightly
The price is $172 total per night from Jul 15 to Jul 16
$172 total
Jul 15 - Jul 16
Total includes taxes and fees
Stay at this 3-star hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
8/10 Very Good! (1,123 reviews)
"Nice quit location right off Duval Street with super clean pools and bars around it."

Reviewed on Jul 11, 2025

The Southernmost Inn - Adults Only
Southwinds Motel
Southwinds Motel
2 out of 5
1321 Simonton Street, Key West, FL
$135 nightly
The price is $152 total per night from Aug 13 to Aug 14
$152 total
Aug 13 - Aug 14
Total includes taxes and fees
Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and a 24-hour front desk. Our guests praise the breakfast and the pool in our reviews. ...
8.6/10 Excellent! (1,122 reviews)
"Older property, but clean and very well kept. The staff were very friendly and helpful."

Reviewed on Jul 11, 2025

Southwinds Motel
Southernmost House
Southernmost House
4 out of 5
1400 Duval Street, Key West, FL
$269 nightly
The price is $303 total per night from Jul 22 to Jul 23
$303 total
Jul 22 - Jul 23
Total includes taxes and fees
Stay at this 4-star beach hotel in Key West. Enjoy free breakfast, free WiFi, and room service. Our guests praise the helpful staff and the property condition ...
9.2/10 Wonderful! (1,008 reviews)
"Great historical place to stay. Staff is amazing. Couldn’t ask for more."

Reviewed on Jul 10, 2025

Southernmost House
Orchid Key Inn - Adults Only
Orchid Key Inn - Adults Only
3.5 out of 5
1004 Duval St, Key West, FL
$179 nightly
The price is $202 total per night from Aug 14 to Aug 15
$202 total
Aug 14 - Aug 15
Total includes taxes and fees
Stay at this 3.5-star hotel in Key West. Enjoy free breakfast, free WiFi, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
9.8/10 Exceptional! (1,007 reviews)
"Very clean, relaxing, and the staff went above and beyond. Highly recommend!"

Reviewed on Jul 13, 2025

Orchid Key Inn - Adults Only
See all 2,798 properties in Uptown - Upper Duval
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighborhoods around Uptown - Upper Duval

Key West Historic District

Old Town Key West

Old Town, the historic heart of Key West, boasts a central business district and numerous tourist attractions. Explore the Key West Aquarium, Ernest Hemingway House, Mallory Square, and more in this vibrant area.

Old Town Key West
Key West featuring a marina, a coastal town and general coastal views

Downtown Key West

If you're spending some time in Downtown Key West, Duval Street and Ernest Hemingway Home and Museum are top sights worth seeing.

Downtown Key West
Harry S. Truman Little White House which includes a house and cycling

Bahama Village

Bahama Village is noteworthy for its historic sites, and you can make a stop at top attractions like Duval Street and Key West Lighthouse and Keeper's Quarters Museum.

Bahama Village
Clarence S. Higgs Memorial Beach Park which includes landscape views, tropical scenes and a sandy beach

Casa Marina

While visiting Casa Marina, you might make a stop by sights like Clarence S. Higgs Memorial Beach Park and Florida Keys Beaches.

Casa Marina
Audubon House and Tropical Gardens featuring a house

Key West Historic District

Old Town Key West boasts a rich history with 2485 historic buildings, and is home to popular attractions like Ernest Hemingway House and Mallory Square. Enjoy the lively atmosphere in the central business district.

Key West Historic District
Great location for great pictures, very nice beach

White Street Gallery District

When in White Street Gallery District, you can plan a visit to Duval Street and Clarence S. Higgs Memorial Beach Park, some noteworthy sights in the nearby area.

White Street Gallery District
See our Where To Stay guide

Uptown - Upper Duval, FL

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