Title:  Midsize Car Rentals in Isla Santa María - Expedia.com

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#  Midsize Car Rental Companies in Isla Santa María

Photo by Delen Wong

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Change your mind  
Penalty-free cancellation on many/select car rentals
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Compare car suppliers and package your flight, hotel, and car to save

## Find Cheap Midsize Car Deals for Isla Santa María

\* Price found within the past 6 days. Click for updated prices.

### Don't see what you're looking for?

See all car rentals in Isla Santa María

[View all cars](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Isla%20Santa%20Mar%C3%ADa,%20Gal%C3%A1pagos,%20Ecuador&dpln=739209696364867584&date1=2/18/2026&date2=2/20/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22midsize%22])

## FAQs for Midsize Car Rentals in Isla Santa María

### Where can I get Midsize car rentals in Isla Santa María

There are several locations and suppliers offering Midsize car rentals throughout Isla Santa María, Galápagos. Click around to view the options in the area, compare and find the best deal that’s most convenient for you on Expedia.com. 
  
### How do I get the best deals on Midsize car rentals in Isla Santa María with Expedia.com?

You can compare the top deals from providers in the area on Expedia.com. Prices may vary depending on travel dates, car type, and pick-up location. Head over to the main [car rentals in Isla Santa María](https://www.expedia.com/Car-Rentals-In-Isla Santa María.d739209696364867584.Car-Rental-Guide) page to see all available offers and car types.
  
### What is the cancellation policy for car rentals in Isla Santa María?

Cancellation policies differ by deal type. There are lots of deals that are free to cancel within your cancellation deadline. A pre-paid Midsize car rental in Isla Santa María will most likely be non-refundable. We recommend filtering by “free cancellation” to see the most flexible options. 
  
### Why should I book my car rental on Expedia.com?

Expedia.com is your one-stop-shop for all your travel needs. You’ll see a large selection and some of the best deals to find your Midsize rental in Isla Santa María. Whether you’re traveling for business or pleasure, whether you’re looking for a short or [long term car rental](https://www.expedia.com/lp/b/car-rental/long-term) we’ve got you covered. Book your car with flights or [hotels in Isla Santa María](https://www.expedia.com/Isla Santa María-Hotels.d739209696364867584.Travel-Guide-Hotels). We’ll bundle them into a [vacation package in Isla Santa María](https://www.expedia.com/Isla Santa María.d739209696364867584.Destination-Travel-Guides) with even more discounts.
  
## Midsize Car Rental Information

| Car type:                                         | Midsize                                                                                                 |
| ------------------------------------------------- | ------------------------------------------------------------------------------------------------------- |
| Price:                                            |                                                                                                         |
| From the airport to your hotel:                   | [Airport Transportation](https://www.expedia.com/ground-transfers?rfrr=car.table.AirportTransportation) |
| From popular domestic and international airports: | [Airport Car Rentals](https://www.expedia.com/lp/b/car-rental/airport)                                  |