Cheap American Airlines flights Manchester (MAN) to San Diego (SAN)

Landing cheap one-way American Airlines flights from MAN to SAN on Expedia is a breeze — just filter by "Price (lowest to highest)." Alternatively, check out our affordable return fares from $836 for your next exciting vacation.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Start your search for American Airlines flights from MAN to SAN about one month before you want to go. The most affordable time to book an international flight is generally 18 to 29 days ahead of your travel date when you can save 17% versus booking four to five months in advance. Regardless of itinerary or ticket type, the best day to book international airfare is usually Sunday. Friday is often the most expensive. Passengers booking on a Sunday can save an average of 17% compared to those who book on a Friday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Sort your results by "Morning" and "Early Morning" to browse the earliest flights from MAN to SAN. Jetting off early means flight cancellations are less likely.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.