$328 Cheap Delta flights Key West (EYW) to San Diego (SAN)

View $328 flight on Tue, Sep 30, 2025Opens in a new window

$328 Cheap Delta flights Key West (EYW) to San Diego (SAN)

Prices were available within the past 7 days and start at $328 for one-way flights and $339 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Tue, Sep 9 - Wed, Sep 24
EYW
Key West
SAN
San Diego
$339 Roundtrip, found 6 days ago
$339
Roundtrip
found 6 days ago
Select Delta flight, departing Tue, Sep 9 from Key West to San Diego, returning Wed, Sep 24, priced at $339 found 6 days ago
Delta
Sun, Aug 31 - Tue, Sep 16
EYW
Key West
SAN
San Diego
$387 Roundtrip, found 6 days ago
$387
Roundtrip
found 6 days ago
Select Delta flight, departing Sun, Aug 31 from Key West to San Diego, returning Tue, Sep 16, priced at $387 found 6 days ago
Delta
Sat, Aug 30 - Sun, Aug 31
EYW
Key West
SAN
San Diego
$389 Roundtrip, found 5 hours ago
$389
Roundtrip
found 5 hours ago
Select Delta flight, departing Sat, Aug 30 from Key West to San Diego, returning Sun, Aug 31, priced at $389 found 5 hours ago
Delta
Sat, Sep 13 - Tue, Sep 30
EYW
Key West
SAN
San Diego
$402 Roundtrip, found 1 day ago
$402
Roundtrip
found 1 day ago
Select Delta flight, departing Sat, Sep 13 from Key West to San Diego, returning Tue, Sep 30, priced at $402 found 1 day ago
Delta
Thu, Sep 4 - Sat, Sep 27
EYW
Key West
SAN
San Diego
$414 Roundtrip, found 1 day ago
$414
Roundtrip
found 1 day ago
Select Delta flight, departing Thu, Sep 4 from Key West to San Diego, returning Sat, Sep 27, priced at $414 found 1 day ago
Delta
Sat, Sep 13 - Sat, Sep 27
EYW
Key West
SAN
San Diego
$427 Roundtrip, found 1 day ago
$427
Roundtrip
found 1 day ago
Select Delta flight, departing Sat, Sep 13 from Key West to San Diego, returning Sat, Sep 27, priced at $427 found 1 day ago
Flights from Key West (EYW) to San Diego (SAN)
Origin airport
Key West Intl.
Destination airport
San Diego Intl.
Airlines serving
American Airlines, Delta, JetBlue Airways, United
Popular airline
Delta
Distance
2210 mi

Frequently asked questions

How much is a Delta Air Lines flight from Key West Intl. Airport (EYW) to San Diego Intl. Airport (SAN)?
Scoring cheap one-way Delta Air Lines flights from EYW to SAN from $328 on Expedia couldn't be easier — just filter by "Price (lowest to highest)." Or check out our budget-friendly return fares from $339 for your next exciting getaway.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.
What is the cheapest month to fly from EYW to SAN with Delta Air Lines?
Browse for return or one-way flights to San Diego in January or November. You could find cheaper fares with Delta Air Lines during these off-peak months.
What is the cheapest time to book flights from Key West Intl. Airport (EYW) to San Diego Intl. Airport (SAN) with Delta Air Lines?
To find cheap Delta Air Lines fares from Key West Intl. Airport (EYW) to San Diego Intl. Airport (SAN), start searching one to three months before your intended departure. Reserving domestic flights 34 to 86 days in advance could save you 25% compared to booking just 6 to 12 days ahead. The day you book can also impact what you pay. Sunday is generally the most affordable, while Monday is often the most expensive for domestic flights. You can save 6% on average by booking your trip on a Sunday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.
Does Delta Air Lines fly nonstop from Key West Intl. Airport (EYW) to San Diego Intl. Airport (SAN)?
To figure out if there's a direct route from EYW to SAN with Delta Air Lines or other carriers, check the "Nonstop" box when looking for flights.
What is the earliest Delta Air Lines flight from EYW to SAN?
Search Delta Air Lines's earliest flights from EYW to SAN by using our "Morning" and "Early Morning" filters. Not only will you arrive sooner, early departures are also 20% less likely to be canceled.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports does Delta Air Lines fly into in San Diego?
Delta Air Lines flights from Key West Intl. Airport (EYW) to San Diego come in to San Diego Intl. Airport (SAN). This is the main entry point to this destination.
Why fly with Delta Air Lines from EYW to SAN?
Heading from EYW to SAN with Delta Air Lines comes with plenty of perks, including a rewarding loyalty program and an excellent in-flight experience. Plus, when booking through Expedia, One Key™ members can earn OneKeyCash™* to spend on select future travel purchases. That's in addition to the Delta SkyMiles points you can earn with Delta Air Lines.*OneKeyCash™ disclaimer - OneKeyCash™ is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
Can I change or cancel my Delta Air Lines flight from Key West Intl. Airport (EYW) to San Diego Intl. Airport (SAN)?
It's usually possible to cancel or reschedule your flight, although there may be a charge if your booking was made over 24 hours ago. Prefer to keep your options open? Use our "No cancel fee" and "Changes included" filters to find flights that won't penalize you if you need to alter your plans. To update your itinerary, visit "Trips," select your flight and click on "Manage Booking" for further information.

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*Available to One Key members.