$241 Cheap Flights from Mobile (MOB) to Panama City (PTY)

View $241 flight on Wed, Oct 21, 2026Opens in a new window

Popular airlines from Mobile Regional Airport (MOB) to Tocumen Intl. Airport (PTY)

Cheap Flights from Mobile to Panama City (MOB-PTY)

Prices were available within the past 7 days and start at $241 for one-way flights and $507 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Mon, Apr 27 - Wed, May 6
MOB
Mobile
PTY
Panama City
$507 Roundtrip, found 7 hours ago
$507
Roundtrip
found 7 hours ago
Select Delta flight, departing Mon, Apr 27 from Mobile to Panama City, returning Wed, May 6, priced at $507 found 7 hours ago
United
Mon, Apr 27 - Wed, May 6
MOB
Mobile
PTY
Panama City
$507 Roundtrip, found 7 hours ago
$507
Roundtrip
found 7 hours ago
Select United flight, departing Mon, Apr 27 from Mobile to Panama City, returning Wed, May 6, priced at $507 found 7 hours ago
American Airlines
Mon, Apr 27 - Wed, May 6
MOB
Mobile
PTY
Panama City
$511 Roundtrip, found 7 hours ago
$511
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Mon, Apr 27 from Mobile to Panama City, returning Wed, May 6, priced at $511 found 7 hours ago
Delta
Mon, Apr 27 - Wed, May 6
MOB
Mobile
PTY
Panama City
$514 Roundtrip, found 7 hours ago
$514
Roundtrip
found 7 hours ago
Select Delta flight, departing Mon, Apr 27 from Mobile to Panama City, returning Wed, May 6, priced at $514 found 7 hours ago
Delta
Mon, Apr 27 - Wed, May 6
MOB
Mobile
PTY
Panama City
$521 Roundtrip, found 7 hours ago
$521
Roundtrip
found 7 hours ago
Select Delta flight, departing Mon, Apr 27 from Mobile to Panama City, returning Wed, May 6, priced at $521 found 7 hours ago
United
Tue, Jun 2 - Tue, Jun 9
MOB
Mobile
PTY
Panama City
$523 Roundtrip, found 6 days ago
$523
Roundtrip
found 6 days ago
Select United flight, departing Tue, Jun 2 from Mobile to Panama City, returning Tue, Jun 9, priced at $523 found 6 days ago
United
Mon, Apr 27 - Wed, May 6
MOB
Mobile
PTY
Panama City
$527 Roundtrip, found 7 hours ago
$527
Roundtrip
found 7 hours ago
Select United flight, departing Mon, Apr 27 from Mobile to Panama City, returning Wed, May 6, priced at $527 found 7 hours ago
American Airlines
Mon, Apr 27 - Wed, May 6
MOB
Mobile
PTY
Panama City
$530 Roundtrip, found 7 hours ago
$530
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Mon, Apr 27 from Mobile to Panama City, returning Wed, May 6, priced at $530 found 7 hours ago
American Airlines
Sat, May 2 - Thu, May 7
MOB
Mobile
PTY
Panama City
$531 Roundtrip, found 2 days ago
$531
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, May 2 from Mobile to Panama City, returning Thu, May 7, priced at $531 found 2 days ago
Delta
Sat, May 2 - Thu, May 7
MOB
Mobile
PTY
Panama City
$534 Roundtrip, found 2 days ago
$534
Roundtrip
found 2 days ago
Select Delta flight, departing Sat, May 2 from Mobile to Panama City, returning Thu, May 7, priced at $534 found 2 days ago

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Frequently asked questions

How much does a flight from Mobile Regional Airport (MOB) to Tocumen Intl. Airport (PTY) cost?
Lock in a cheap one-way flight from $241 or cheap return flight from $507 from Mobile Regional Airport (MOB) to Tocumen Intl. Airport (PTY) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Mobile Regional Airport (MOB) to Tocumen Intl. Airport (PTY)?
The cheapest month to fly from MOB to PTY is April, when demand is low. Off-peak months are often when you'll find cheap fares for travel between these airports.
What is the cheapest airline that flies from Mobile Regional Airport (MOB) to Tocumen Intl. Airport (PTY)?
Use the filters on Expedia to compare different airlines and find the cheapest carrier that'll fly you from MOB to PTY. Then, sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from Mobile Regional Airport (MOB) to Tocumen Intl. Airport (PTY)?
There aren't any daily nonstop flights available from Mobile Regional Airport (MOB) to Tocumen Intl. Airport (PTY). But you can opt for flights with layovers. Filter your search results on Expedia to include one or two stops, and you'll be on your way in no time.
What day of the week has the most flights from MOB to PTY?
Friday is typically the busiest day for flights, while Tuesday tends to be the quietest.* Just remember that flight schedules can change based on a range of factors, including the time of year and carrier.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Mobile Regional Airport (MOB) to Tocumen Intl. Airport (PTY)?
To avoid potential delays on the Mobile Regional Airport (MOB) to Tocumen Intl. Airport (PTY) route, aim to travel before 3 PM. Departures after this time are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Mobile Regional Airport (MOB) to Tocumen Intl. Airport (PTY) last-minute?
Waiting until right before your break to book a ticket from MOB to PTY often results in higher prices. Although you may find some last-minute offers, they aren't always guaranteed. Keep your travel plans flexible for the best chance of getting a bargain.
Is it cheaper to book a MOB to PTY flight and hotel package?
Compared with arranging hotels and flights separately, booking a MOB to PTY flight and hotel package with Expedia could lead to significant savings. What's more, having everything in one easy place will take the hassle out of planning your trip. Just pick your flights and choose from our wide range of hotels, then customize your trip with other add-ons like activities, tours and car rentals.
Can I cancel or change the date of my flight from Mobile Regional Airport (MOB) to Tocumen Intl. Airport (PTY)?
You can usually cancel or reschedule your MOB to PTY flight. However, if it's been more than 24 hours since booking, additional fees may apply. Refer to your airline's policies in your itinerary to see what changes are allowed and whether any costs are involved. You'll also find more information on our Customer Service portal.

Travel information

Origin airport
Mobile Regional
Destination airport
Tocumen Intl.
Roundtrip price
$506
Distance
1598 mi

Book with confidence

Mobile to Panama City Flights

The cheapest times to fly from Mobile to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Mobile to Panama City are during the month of April. You can find some of the cheapest flights from Mobile to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Mobile to Panama City

Sunday is one of the best days to book for cheap flights from Mobile to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Mobile to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Mobile to Panama City in 2026. You can also book with separate airlines for your outbound and return journeys, from $241 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Mobile to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Mobile to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Mobile to Panama City Flights

*Flight schedules are subject to change.

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*Available to One Key members.