$324 Cheap Flights from Minneapolis (MSP) to Panama City (PTY)

View $324 flight on Wed, Feb 18, 2026Opens in a new window

Popular airlines from Minneapolis - St. Paul Intl. Airport (MSP) to Tocumen Intl. Airport (PTY)

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Cheap Flights from Minneapolis to Panama City (MSP-PTY)

Prices were available within the past 7 days and start at $324 for one-way flights and $583 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Wed, Feb 18 - Wed, Feb 25
MSP
Minneapolis
PTY
Panama City
$583 Roundtrip, just found
$583
Roundtrip
just found
Select Delta flight, departing Wed, Feb 18 from Minneapolis to Panama City, returning Wed, Feb 25, priced at $583 just found
American Airlines
Wed, Feb 18 - Wed, Feb 25
MSP
Minneapolis
PTY
Panama City
$588 Roundtrip, just found
$588
Roundtrip
just found
Select American Airlines flight, departing Wed, Feb 18 from Minneapolis to Panama City, returning Wed, Feb 25, priced at $588 just found
United
Thu, Nov 6 - Thu, Nov 27
MSP
Minneapolis
PTY
Panama City
$594 Roundtrip, found 2 days ago
$594
Roundtrip
found 2 days ago
Select United flight, departing Thu, Nov 6 from Minneapolis to Panama City, returning Thu, Nov 27, priced at $594 found 2 days ago
Delta
Wed, Feb 18 - Wed, Feb 25
MSP
Minneapolis
PTY
Panama City
$594 Roundtrip, just found
$594
Roundtrip
just found
Select Delta flight, departing Wed, Feb 18 from Minneapolis to Panama City, returning Wed, Feb 25, priced at $594 just found
American Airlines
Mon, Jan 12 - Wed, Jan 21
MSP
Minneapolis
PTY
Panama City
$598 Roundtrip, found 7 hours ago
$598
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Mon, Jan 12 from Minneapolis to Panama City, returning Wed, Jan 21, priced at $598 found 7 hours ago
United
Tue, Feb 17 - Tue, Feb 24
MSP
Minneapolis
PTY
Panama City
$599 Roundtrip, found 8 hours ago
$599
Roundtrip
found 8 hours ago
Select United flight, departing Tue, Feb 17 from Minneapolis to Panama City, returning Tue, Feb 24, priced at $599 found 8 hours ago
American Airlines
Mon, Jan 12 - Wed, Jan 21
MSP
Minneapolis
PTY
Panama City
$603 Roundtrip, found 7 hours ago
$603
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Mon, Jan 12 from Minneapolis to Panama City, returning Wed, Jan 21, priced at $603 found 7 hours ago
Delta
Mon, Nov 10 - Mon, Nov 17
MSP
Minneapolis
PTY
Panama City
$605 Roundtrip, found 6 hours ago
$605
Roundtrip
found 6 hours ago
Select Delta flight, departing Mon, Nov 10 from Minneapolis to Panama City, returning Mon, Nov 17, priced at $605 found 6 hours ago
Copa
Mon, Jan 12 - Mon, Jan 19
MSP
Minneapolis
PTY
Panama City
$763 Roundtrip, found 3 days ago
$763
Roundtrip
found 3 days ago
Select Copa flight, departing Mon, Jan 12 from Minneapolis to Panama City, returning Mon, Jan 19, priced at $763 found 3 days ago
avianca
Sat, Dec 6 - Fri, Jan 9
MSP
Minneapolis
PTY
Panama City
$1,724 Roundtrip, just found
$1,724
Roundtrip
just found
Select avianca flight, departing Sat, Dec 6 from Minneapolis to Panama City, returning Fri, Jan 9, priced at $1,724 just found

Find the cheapest month to fly from Minneapolis (MSP) to Panama City (PTY)

August is typically the cheapest month to fly

From $560 - $1,758 per traveler.

Graph displaying average flight prices per month

Alternative airports near Panama City

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Tocumen Intl. PTY. Cheapest option available. Average driving time to city center is 16 minutes. Flights from $1,068
PTY
Tocumen Intl.
Cheapest
Average driving time to city center16 min
Flights from $1,068
Flights from Minneapolis (MSP) to Panama City (PTY)
Origin airport
Minneapolis - St. Paul Intl.
Destination airport
Tocumen Intl.
Airlines serving
American Airlines, Copa, Delta, United, avianca
Roundtrip price
$583
Distance
2608 mi

Minneapolis to Panama City Flights

The cheapest times to fly from Minneapolis to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Minneapolis to Panama City are during the month of February. You can find some of the cheapest flights from Minneapolis to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Minneapolis to Panama City

Sunday is one of the best days to book for cheap flights from Minneapolis to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Minneapolis to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Minneapolis to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $324 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Minneapolis to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Minneapolis to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Minneapolis - St. Paul Intl. Airport (MSP) to Tocumen Intl. Airport (PTY) cost?
Discover the latest flight deals from MSP to PTY by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from MSP to PTY?
The cheapest flights from MSP to PTY are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from MSP to PTY?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from MSP to PTY. Sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from Minneapolis - St. Paul Intl. Airport (MSP) to Tocumen Intl. Airport (PTY)?
You'll have to catch a flight with a layover when traveling from Minneapolis - St. Paul Intl. Airport (MSP) to Tocumen Intl. Airport (PTY). There are no daily direct flights on this route. However, just filter your search to include one or more stops to discover an option that works for you.
What day of the week has the most flights from MSP to PTY?
Friday is usually the busiest day for flights, while Tuesday tends to be the quietest.* Remember that flight schedules can change depending on a range of factors, such as the time of year and carrier.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Minneapolis - St. Paul Intl. Airport (MSP) to Tocumen Intl. Airport (PTY)?
Opt for a flight from Minneapolis - St. Paul Intl. Airport (MSP) to Tocumen Intl. Airport (PTY) that takes off before 3 PM to reduce the risk of delays and cancellations. Later departures are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Minneapolis - St. Paul Intl. Airport (MSP) to Tocumen Intl. Airport (PTY) last-minute?
Booking your plane ticket from MSP to PTY right before your getaway is usually more expensive. However, if you're flexible with your departure dates and times, you could grab a cheap last-minute fare.
Is it cheaper to book a MSP to PTY flight and hotel package?
Opting for a MSP to PTY flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your trip all in one place. Select from our wide range of accommodations and then add car rentals, flights and activities to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Minneapolis - St. Paul Intl. Airport (MSP) to Tocumen Intl. Airport (PTY)?
If you booked your MSP to PTY flight in the last 24 hours, you may be able to modify or cancel it without fees. Depending on the airline and the type of ticket you purchased, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for further details.

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*Available to One Key members.