$121 Cheap Flights from Myrtle Beach (MYR) to Medellín (MDE)

View $121 flight on Tue, Aug 12, 2025Opens in a new window

Popular airlines from Myrtle Beach Intl. Airport (MYR) to Jose Maria Cordova Intl. Airport (MDE)

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Cheap Flights from Myrtle Beach to Medellín (MYR-MDE)

Prices were available within the past 7 days and start at $121 for one-way flights and $389 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Spirit Airlines
Fri, Jul 18 - Fri, Jul 25
MYR
Myrtle Beach
MDE
Medellin
$389 Roundtrip, found 6 days ago
$389
Roundtrip
found 6 days ago
Select Spirit Airlines flight, departing Fri, Jul 18 from Myrtle Beach to Medellin, returning Fri, Jul 25, priced at $389 found 6 days ago
Spirit Airlines
Sat, Jul 26 - Wed, Jul 30
MYR
Myrtle Beach
MDE
Medellin
$403 Roundtrip, found 7 hours ago
$403
Roundtrip
found 7 hours ago
Select Spirit Airlines flight, departing Sat, Jul 26 from Myrtle Beach to Medellin, returning Wed, Jul 30, priced at $403 found 7 hours ago
Spirit Airlines
Sun, Jul 20 - Wed, Jul 23
MYR
Myrtle Beach
MDE
Medellin
$422 Roundtrip, found 1 day ago
$422
Roundtrip
found 1 day ago
Select Spirit Airlines flight, departing Sun, Jul 20 from Myrtle Beach to Medellin, returning Wed, Jul 23, priced at $422 found 1 day ago
Spirit Airlines
Wed, Jul 30 - Mon, Aug 4
MYR
Myrtle Beach
MDE
Medellin
$434 Roundtrip, found 1 day ago
$434
Roundtrip
found 1 day ago
Select Spirit Airlines flight, departing Wed, Jul 30 from Myrtle Beach to Medellin, returning Mon, Aug 4, priced at $434 found 1 day ago
Spirit Airlines
Sat, Jul 12 - Wed, Jul 16
MYR
Myrtle Beach
MDE
Medellin
$450 Roundtrip, found 1 day ago
$450
Roundtrip
found 1 day ago
Select Spirit Airlines flight, departing Sat, Jul 12 from Myrtle Beach to Medellin, returning Wed, Jul 16, priced at $450 found 1 day ago
Spirit Airlines
Sun, Jul 20 - Wed, Jul 23
MYR
Myrtle Beach
MDE
Medellin
$453 Roundtrip, found 1 day ago
$453
Roundtrip
found 1 day ago
Select Spirit Airlines flight, departing Sun, Jul 20 from Myrtle Beach to Medellin, returning Wed, Jul 23, priced at $453 found 1 day ago
American Airlines
Wed, Sep 10 - Wed, Sep 24
MYR
Myrtle Beach
MDE
Medellin
$531 Roundtrip, found 6 hours ago
$531
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Wed, Sep 10 from Myrtle Beach to Medellin, returning Wed, Sep 24, priced at $531 found 6 hours ago
United
Sat, Jul 12 - Wed, Jul 16
MYR
Myrtle Beach
MDE
Medellin
$540 Roundtrip, found 1 day ago
$540
Roundtrip
found 1 day ago
Select United flight, departing Sat, Jul 12 from Myrtle Beach to Medellin, returning Wed, Jul 16, priced at $540 found 1 day ago
Delta
Tue, Sep 9 - Mon, Sep 22
MYR
Myrtle Beach
MDE
Medellin
$554 Roundtrip, found 6 hours ago
$554
Roundtrip
found 6 hours ago
Select Delta flight, departing Tue, Sep 9 from Myrtle Beach to Medellin, returning Mon, Sep 22, priced at $554 found 6 hours ago
LATAM Airlines Group
Thu, Oct 2 - Mon, Oct 13
MYR
Myrtle Beach
MDE
Medellin
$690 Roundtrip, found 5 hours ago
$690
Roundtrip
found 5 hours ago
Select LATAM Airlines Group flight, departing Thu, Oct 2 from Myrtle Beach to Medellin, returning Mon, Oct 13, priced at $690 found 5 hours ago
Flights from Myrtle Beach (MYR) to Medellín (MDE)
Origin airport
Myrtle Beach Intl.
Destination airport
José María Córdova Intl.
Airlines serving
American Airlines, Delta, LATAM Airlines Group, Spirit Airlines, United
Roundtrip price
$389
Distance
1913 mi

Myrtle Beach to Medellín Flights

The cheapest times to fly from Myrtle Beach to Medellín

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Myrtle Beach to Medellín are during the month of July. You can find some of the cheapest flights from Myrtle Beach to Medellín with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Myrtle Beach to Medellín

Sunday is one of the best days to book for cheap flights from Myrtle Beach to Medellín: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Myrtle Beach to Medellín

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Myrtle Beach to Medellín in 2025. You can also book with separate airlines for your outbound and return journeys, from $121 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Myrtle Beach to Medellín flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Myrtle Beach to Medellín airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Myrtle Beach Intl. Airport (MYR) to Jose Maria Cordova Intl. Airport (MDE) cost?
Discover the latest flight deals from MYR to MDE by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from MYR to MDE?
The cheapest flights from MYR to MDE are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from MYR to MDE?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from MYR to MDE. Sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from Myrtle Beach Intl. Airport (MYR) to Jose Maria Cordova Intl. Airport (MDE)?
You'll need to book a flight with a layover when traveling from Myrtle Beach Intl. Airport (MYR) to Jose Maria Cordova Intl. Airport (MDE). Direct flights don't operate daily on this route. However, simply filter your search to include one or two stops to find an option that works for you.
What day of the week has the most flights from MYR to MDE?
You'll typically find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can change from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Myrtle Beach Intl. Airport (MYR) to Jose Maria Cordova Intl. Airport (MDE)?
To avoid possible delays on the Myrtle Beach Intl. Airport (MYR) to Jose Maria Cordova Intl. Airport (MDE) route, aim to travel before 3 PM. Later departures have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Myrtle Beach Intl. Airport (MYR) to Jose Maria Cordova Intl. Airport (MDE) last-minute?
Last-minute bookings from MYR to MDE are typically more expensive. To secure the best rates, start looking for flights early. That being said, if you're flexible with your travel dates, it's possible to find a cheap fare right before you leave.
Is it cheaper to book a MYR to MDE flight and hotel package?
Compared with arranging hotels and flights separately, booking a MYR to MDE flight and hotel package with Expedia could lead to significant savings. Better yet, having everything in one convenient place takes the hassle out of planning your trip. Simply pick your flights and select from our extensive range of hotels, then personalize your trip with extras like tours, activities and car rentals.
Can I cancel or change the date of my flight from Myrtle Beach Intl. Airport (MYR) to Jose Maria Cordova Intl. Airport (MDE)?
If you reserved your MYR to MDE flight in the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the type of ticket you purchased, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for more information.

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*Available to One Key members.