$291 Cheap Flights from Panama City (PTY) to Key West (EYW)

View $291 flight on Tue, Oct 28, 2025Opens in a new window

Popular airlines from Tocumen Intl. Airport (PTY) to Key West Intl. Airport (EYW)

Cheap Flights from Panama City to Key West (PTY-EYW)

Prices were available within the past 7 days and start at $291 for one-way flights and $538 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Sun, Feb 1 - Sun, Feb 8
PTY
Panama City
EYW
Key West
$538 Roundtrip, found 6 days ago
$538
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sun, Feb 1 from Panama City to Key West, returning Sun, Feb 8, priced at $538 found 6 days ago
American Airlines
Sun, Feb 1 - Sun, Feb 8
PTY
Panama City
EYW
Key West
$545 Roundtrip, found 6 days ago
$545
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sun, Feb 1 from Panama City to Key West, returning Sun, Feb 8, priced at $545 found 6 days ago
American Airlines
Sun, Feb 1 - Sun, Feb 8
PTY
Panama City
EYW
Key West
$551 Roundtrip, found 6 days ago
$551
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sun, Feb 1 from Panama City to Key West, returning Sun, Feb 8, priced at $551 found 6 days ago
Delta
Tue, Oct 28 - Sun, Nov 2
PTY
Panama City
EYW
Key West
$570 Roundtrip, found 6 days ago
$570
Roundtrip
found 6 days ago
Select Delta flight, departing Tue, Oct 28 from Panama City to Key West, returning Sun, Nov 2, priced at $570 found 6 days ago
Delta
Fri, Oct 24 - Tue, Oct 28
PTY
Panama City
EYW
Key West
$582 Roundtrip, found 2 days ago
$582
Roundtrip
found 2 days ago
Select Delta flight, departing Fri, Oct 24 from Panama City to Key West, returning Tue, Oct 28, priced at $582 found 2 days ago
Delta
Fri, Oct 31 - Sun, Nov 2
PTY
Panama City
EYW
Key West
$592 Roundtrip, found 6 days ago
$592
Roundtrip
found 6 days ago
Select Delta flight, departing Fri, Oct 31 from Panama City to Key West, returning Sun, Nov 2, priced at $592 found 6 days ago
Delta
Tue, Oct 28 - Fri, Oct 31
PTY
Panama City
EYW
Key West
$603 Roundtrip, found 6 days ago
$603
Roundtrip
found 6 days ago
Select Delta flight, departing Tue, Oct 28 from Panama City to Key West, returning Fri, Oct 31, priced at $603 found 6 days ago
Delta
Fri, Oct 24 - Sat, Oct 25
PTY
Panama City
EYW
Key West
$603 Roundtrip, found 2 days ago
$603
Roundtrip
found 2 days ago
Select Delta flight, departing Fri, Oct 24 from Panama City to Key West, returning Sat, Oct 25, priced at $603 found 2 days ago
Delta
Tue, Oct 28 - Wed, Oct 29
PTY
Panama City
EYW
Key West
$624 Roundtrip, found 6 days ago
$624
Roundtrip
found 6 days ago
Select Delta flight, departing Tue, Oct 28 from Panama City to Key West, returning Wed, Oct 29, priced at $624 found 6 days ago
United
Sun, Feb 1 - Sun, Feb 8
PTY
Panama City
EYW
Key West
$7,747 Roundtrip, found 6 days ago
$7,747
Roundtrip
found 6 days ago
Select United flight, departing Sun, Feb 1 from Panama City to Key West, returning Sun, Feb 8, priced at $7,747 found 6 days ago
Flights from Panama City (PTY) to Key West (EYW)
Origin airport
Tocumen Intl.
Destination airport
Key West Intl.
Airlines serving
American Airlines, Delta
Roundtrip price
$538
Distance
1081 mi

Panama City to Key West Flights

The cheapest times to fly from Panama City to Key West

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Panama City to Key West are during the month of February. You can find some of the cheapest flights from Panama City to Key West with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Panama City to Key West

Sunday is one of the best days to book for cheap flights from Panama City to Key West: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Panama City to Key West

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Panama City to Key West in 2025. You can also book with separate airlines for your outbound and return journeys, from $291 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Panama City to Key West flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Panama City to Key West airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Tocumen Intl. Airport (PTY) to Key West Intl. Airport (EYW) cost?
Grab a cheap one-way flight from $291 or cheap return flight from $538 from Tocumen Intl. Airport (PTY) to Key West Intl. Airport (EYW) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Tocumen Intl. Airport (PTY) to Key West Intl. Airport (EYW)?
February is the least expensive month to fly from PTY to EYW. Traveling during an off-peak travel window is often the key to finding better deals on flights.
What is the cheapest airline that flies from Tocumen Intl. Airport (PTY) to Key West Intl. Airport (EYW)?
To find the cheapest airline flying from PTY to EYW, use Expedia's filter tool. Customize your search based on your travel needs, such as preferred carriers and cabin class. You can then sort your results by "Price (lowest to highest)" to list the most affordable options first.
How many flights per day from Tocumen Intl. Airport (PTY) to Key West Intl. Airport (EYW)?
Direct flights from Tocumen Intl. Airport (PTY) to Key West Intl. Airport (EYW) aren't available daily, so you'll need to take a flight with a layover. Explore your options with our filter tool. Enter your travel dates and click on either "1 Stop" or "2+ Stops."
What day of the week has the most flights from PTY to EYW?
Friday is typically the busiest day for flights, while Tuesday tends to be the quietest.* Just remember that flight schedules can vary based on a range of factors, such as the airline and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Tocumen Intl. Airport (PTY) to Key West Intl. Airport (EYW)?
Opt for a flight from Tocumen Intl. Airport (PTY) to Key West Intl. Airport (EYW) that takes off before 3 PM to reduce the risk of delays and cancellations. Departures after this hour have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Tocumen Intl. Airport (PTY) to Key West Intl. Airport (EYW) last-minute?
Holding off until right before your break to book a flight from PTY to EYW often results in higher prices. While you may come across some last-minute offers, they're not always guaranteed. Keep your travel plans flexible for the best chance of scoring a bargain.
Is it cheaper to book a PTY to EYW flight and hotel package?
Compared with arranging flights and hotels separately, booking a PTY to EYW flight and hotel package with Expedia could lead to significant savings. What's more, having everything in one easy place takes the hassle out of planning your trip. Just secure your flights and choose from our extensive range of stays, then customize your trip with other add-ons like tours and car rentals.
Can I cancel or change the date of my flight from Tocumen Intl. Airport (PTY) to Key West Intl. Airport (EYW)?
In most cases, you can reschedule or cancel your PTY to EYW flight. However, additional charges may apply, especially if you booked over 24 hours ago. Double-check your itinerary for the airline's rules and fees on flight changes, or if you'd like more details, head to our Customer Service portal.

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*Available to One Key members.