$382 Cheap Flights from Reynosa (REX) to Panama City (PTY)

View $382 flight on Fri, Sep 19, 2025Opens in a new window

Popular airlines from Reynosa, Tamaulipas (REX-General Lucio Blanco Intl.) to Tocumen Intl. Airport (PTY)

Cheap Flights from Reynosa to Panama City (REX-PTY)

Prices were available within the past 7 days and start at $382 for one-way flights and $576 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Aeromexico
Tue, Oct 14 - Wed, Nov 5
REX
Reynosa
PTY
Panama City
$576 Roundtrip, found 4 days ago
$576
Roundtrip
found 4 days ago
Select Aeromexico flight, departing Tue, Oct 14 from Reynosa to Panama City, returning Wed, Nov 5, priced at $576 found 4 days ago
Aeromexico
Tue, Feb 3 - Sat, Feb 14
REX
Reynosa
PTY
Panama City
$700 Roundtrip, found 6 days ago
$700
Roundtrip
found 6 days ago
Select Aeromexico flight, departing Tue, Feb 3 from Reynosa to Panama City, returning Sat, Feb 14, priced at $700 found 6 days ago
Aeromexico
Wed, Oct 15 - Wed, Nov 5
REX
Reynosa
PTY
Panama City
$717 Roundtrip, found 4 days ago
$717
Roundtrip
found 4 days ago
Select Aeromexico flight, departing Wed, Oct 15 from Reynosa to Panama City, returning Wed, Nov 5, priced at $717 found 4 days ago
Aeromexico
Tue, Oct 14 - Sat, Nov 1
REX
Reynosa
PTY
Panama City
$738 Roundtrip, found 4 days ago
$738
Roundtrip
found 4 days ago
Select Aeromexico flight, departing Tue, Oct 14 from Reynosa to Panama City, returning Sat, Nov 1, priced at $738 found 4 days ago
Aeromexico
Thu, Oct 16 - Wed, Nov 5
REX
Reynosa
PTY
Panama City
$761 Roundtrip, found 4 days ago
$761
Roundtrip
found 4 days ago
Select Aeromexico flight, departing Thu, Oct 16 from Reynosa to Panama City, returning Wed, Nov 5, priced at $761 found 4 days ago
Viva
Mon, Feb 2 - Tue, Feb 3
REX
Reynosa
PTY
Panama City
$849 Roundtrip, found 6 days ago
$849
Roundtrip
found 6 days ago
Select Viva flight, departing Mon, Feb 2 from Reynosa to Panama City, returning Tue, Feb 3, priced at $849 found 6 days ago
Aeromexico
Tue, Feb 3 - Sat, Feb 14
REX
Reynosa
PTY
Panama City
$871 Roundtrip, found 6 days ago
$871
Roundtrip
found 6 days ago
Select Aeromexico flight, departing Tue, Feb 3 from Reynosa to Panama City, returning Sat, Feb 14, priced at $871 found 6 days ago
Viva
Tue, Feb 3 - Wed, Feb 4
REX
Reynosa
PTY
Panama City
$882 Roundtrip, found 6 days ago
$882
Roundtrip
found 6 days ago
Select Viva flight, departing Tue, Feb 3 from Reynosa to Panama City, returning Wed, Feb 4, priced at $882 found 6 days ago
Viva
Mon, Feb 2 - Tue, Feb 3
REX
Reynosa
PTY
Panama City
$898 Roundtrip, found 6 days ago
$898
Roundtrip
found 6 days ago
Select Viva flight, departing Mon, Feb 2 from Reynosa to Panama City, returning Tue, Feb 3, priced at $898 found 6 days ago
Viva
Tue, Feb 3 - Wed, Feb 4
REX
Reynosa
PTY
Panama City
$904 Roundtrip, found 6 days ago
$904
Roundtrip
found 6 days ago
Select Viva flight, departing Tue, Feb 3 from Reynosa to Panama City, returning Wed, Feb 4, priced at $904 found 6 days ago
Flights from Reynosa (REX) to Panama City (PTY)
Origin airport
General Lucio Blanco Intl.
Destination airport
Tocumen Intl.
Roundtrip price
$576
Distance
1701 mi

Reynosa to Panama City Flights

The cheapest times to fly from Reynosa to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Reynosa to Panama City are during the month of October. You can find some of the cheapest flights from Reynosa to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Reynosa to Panama City

Sunday is one of the best days to book for cheap flights from Reynosa to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Reynosa to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Reynosa to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $382 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Reynosa to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Reynosa to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from General Lucio Blanco Intl. Airport (REX) to Tocumen Intl. Airport (PTY) cost?
Lock in a cheap one-way flight from $382 or cheap return flight from $576 from General Lucio Blanco Intl. Airport (REX) to Tocumen Intl. Airport (PTY) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from General Lucio Blanco Intl. Airport (REX) to Tocumen Intl. Airport (PTY)?
The cheapest month to fly from REX to PTY is October, when demand is low. Off-peak season is usually when you'll find lower airfares between these airports.
What is the cheapest airline that flies from General Lucio Blanco Intl. Airport (REX) to Tocumen Intl. Airport (PTY)?
To find the cheapest airline that'll fly you from REX to PTY, use Expedia's filter tool. Tailor your search based on what's important to you, such as preferred carriers and ideal departure window. You can then sort your results by "Price (lowest to highest)" to see the most affordable options first.
How many flights per day from General Lucio Blanco Intl. Airport (REX) to Tocumen Intl. Airport (PTY)?
There aren't any daily nonstop flights available from General Lucio Blanco Intl. Airport (REX) to Tocumen Intl. Airport (PTY). But you can choose flights with layovers. Filter your search results on Expedia to include one or more stops, and you'll be on your way in no time at all.
What day of the week has the most flights from REX to PTY?
Typically you'll find the most flight options available on a Friday. Tuesdays are often the quietest.* However, this can change based on the season, carrier and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from General Lucio Blanco Intl. Airport (REX) to Tocumen Intl. Airport (PTY)?
Opt for a flight from General Lucio Blanco Intl. Airport (REX) to Tocumen Intl. Airport (PTY) that takes off before 3 PM to reduce the likelihood of delays. Later departures have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from General Lucio Blanco Intl. Airport (REX) to Tocumen Intl. Airport (PTY) last-minute?
Holding off until just before your trip to book a flight from REX to PTY often results in higher prices. While you might find some last-minute discounts, they're not always guaranteed. Keep your travel plans flexible to boost your chances of scoring a bargain.
Is it cheaper to book a REX to PTY flight and hotel package?
You can save money by booking a REX to PTY flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's easy to manage everything in one convenient place. After selecting your ideal flights and accommodations, you can add extras like tours, car rentals and activities.
Can I cancel or change the date of my flight from General Lucio Blanco Intl. Airport (REX) to Tocumen Intl. Airport (PTY)?
It's usually possible to cancel or reschedule your REX to PTY flight. However, if the booking was made more than 24 hours ago, additional charges may apply. Refer to your airline's policies in your itinerary to see what changes are allowed and if any costs are involved. You'll also find further details on our Customer Service portal.

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*Available to One Key members.