$438 Cheap American Airlines flights San Diego (SAN) to Islip (ISP)

Finding cheap one-way American Airlines flights from SAN to ISP from $438 on Expedia is simple --- just filter by "Price (lowest to highest)." Or check out our budget-friendly round-trip fares from $865 for your next exciting adventure.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Search for cheap American Airlines flights from San Diego Intl. Airport (SAN) to MacArthur Airport (ISP) one to three months prior to your day of departure. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. No matter the fare type and journey, the ideal day to book a domestic flight is generally Sunday and the most expensive day is typically Monday. Passengers who book on a Sunday can save 6% on average compared to those who book on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Search American Airlines's earliest flights from SAN to ISP by using the "Morning" and "Early Morning" filters. Not only will you arrive at your destination sooner, early departures also have a 20% less chance of being canceled.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.