$110 Cheap Delta flights Detroit (DTW) to St. Louis (STL)

You can find cheap round-trip Delta Air Lines flights from $205 from DTW to STL by sorting your results from "Price (lowest to highest)" on Expedia. Or search for bargains from $110 for a one-way journey.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Begin your search one to three months before your departure to score cheaper fares on Delta Air Lines flights from Detroit Metropolitan Wayne County Airport (DTW) to Lambert-St. Louis Intl. Airport (STL). You can save 25% by booking your domestic flight 34 to 86 days in advance versus last-minute reservations made 6 to 12 days out. You could also reduce costs by buying your fare on a Sunday, as it's 6% cheaper on average than a Monday, the most expensive day to book.* Nail your timing, and you can enjoy significant savings on domestic flights.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

The earliest flight from DTW to STL with Delta Air Lines leaves at 8:40AM UTC-5. You'll land at 9:36AM UTC-6. The final Delta Air Lines flight of the day leaves at 8:55PM UTC-5 and arrives at 9:49PM UTC-6. With approximately 20% fewer cancellations for early and mid-morning departures, setting off early is often the smartest choice.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.

With an excellent in-flight experience and a rewarding loyalty program, Delta Air Lines is the leading choice for many travelers heading from DTW to STL. Also, if you're a Delta SkyMiles and One Key™ member booking through Expedia, you could earn OneKeyCash™* on eligible flights on top of your airline miles, which you can put toward future trips.*OneKeyCash™ disclaimer - OneKeyCash™ is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.