$143 Cheap Delta flights Tampa (TPA) to Des Moines (DSM)

You’ll find affordable return Delta Air Lines flights from $285 from TPA to DSM by sorting your results from “Price (lowest to highest)” on Expedia. Or look for options from $143 for a one-way trip.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Search for round-trip or one-way flights to Des Moines in January or December. You could find an affordable fare with Delta Air Lines during these off-peak travel months.

Search for cheap Delta Air Lines flights from Tampa Intl. Airport (TPA) to Des Moines Intl. Airport (DSM) one to three months ahead of your departure. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. No matter the fare class and journey, the best day of the week to book a domestic flight is usually Sunday and the most expensive is typically Monday. Passengers who book on a Sunday can save 6% on average compared to those who book on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

Enter your dates, click search and select the “Nonstop” filter on Expedia to find any direct flights from TPA to DSM with Delta Air Lines or other airlines.

Search Delta Air Lines’s earliest flights from TPA to DSM by checking our “Morning” and “Early Morning” filters. Not only will you arrive at your destination sooner, early departures also experience 20% fewer cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

Take a Delta Air Lines flight from Tampa Intl. Airport (TPA) to Des Moines, and you’ll likely come in to Des Moines Intl. Airport (DSM). This is the airline’s main hub in this destination.

Traveling from TPA to DSM with Delta Air Lines means enjoying a variety of perks, such as an excellent in-flight experience and a rewarding loyalty program. Plus, when you book through Expedia, One Key™ members can earn OneKeyCash™* to use on select future travel purchases. That’s on top of the Delta SkyMiles points you can earn with Delta Air Lines.*OneKeyCash™ disclaimer - OneKeyCash™ is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.

Changes are typically free within 24 hours of making a booking, but your airline may charge you after that. For further details about modifying your flights, go to your “Trips,” select your flight and click on “Manage Booking.” If you’d like the flexibility to change your plans without additional charges, tick the “Changes included” and “No cancel fee” filters when planning your next adventure.