$455 Cheap Flights from Des Moines (DSM) to Cusco (CUZ)

View $455 flight on Tue, Nov 10, 2026Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Alejandro Velasco Astete Intl. Airport (CUZ)

Cheap Flights from Des Moines to Cusco (DSM-CUZ)

Prices were available within the past 7 days and start at $455 for one-way flights and $899 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

avianca
Tue, Oct 6 - Tue, Oct 13
DSM
Des Moines
CUZ
Cusco
$899 Roundtrip, found 12 hours ago
$899
Roundtrip
found 12 hours ago
Select avianca flight, departing Tue, Oct 6 from Des Moines to Cusco, returning Tue, Oct 13, priced at $899 found 12 hours ago
avianca
Tue, Oct 6 - Tue, Oct 13
DSM
Des Moines
CUZ
Cusco
$1,029 Roundtrip, found 12 hours ago
$1,029
Roundtrip
found 12 hours ago
Select avianca flight, departing Tue, Oct 6 from Des Moines to Cusco, returning Tue, Oct 13, priced at $1,029 found 12 hours ago
Delta
Wed, Aug 19 - Wed, Aug 26
DSM
Des Moines
CUZ
Cusco
$1,095 Roundtrip, found 4 hours ago
$1,095
Roundtrip
found 4 hours ago
Select Delta flight, departing Wed, Aug 19 from Des Moines to Cusco, returning Wed, Aug 26, priced at $1,095 found 4 hours ago
avianca
Tue, Oct 6 - Tue, Oct 13
DSM
Des Moines
CUZ
Cusco
$1,111 Roundtrip, found 12 hours ago
$1,111
Roundtrip
found 12 hours ago
Select avianca flight, departing Tue, Oct 6 from Des Moines to Cusco, returning Tue, Oct 13, priced at $1,111 found 12 hours ago
LATAM Airlines Group
Wed, Aug 19 - Wed, Aug 26
DSM
Des Moines
CUZ
Cusco
$1,126 Roundtrip, found 4 hours ago
$1,126
Roundtrip
found 4 hours ago
Select LATAM Airlines Group flight, departing Wed, Aug 19 from Des Moines to Cusco, returning Wed, Aug 26, priced at $1,126 found 4 hours ago
Delta
Wed, Aug 19 - Wed, Aug 26
DSM
Des Moines
CUZ
Cusco
$1,178 Roundtrip, found 4 hours ago
$1,178
Roundtrip
found 4 hours ago
Select Delta flight, departing Wed, Aug 19 from Des Moines to Cusco, returning Wed, Aug 26, priced at $1,178 found 4 hours ago
Delta
Sun, Aug 16 - Mon, Aug 24
DSM
Des Moines
CUZ
Cusco
$1,185 Roundtrip, found 1 day ago
$1,185
Roundtrip
found 1 day ago
Select Delta flight, departing Sun, Aug 16 from Des Moines to Cusco, returning Mon, Aug 24, priced at $1,185 found 1 day ago
LATAM Airlines Group
Wed, Aug 19 - Wed, Aug 26
DSM
Des Moines
CUZ
Cusco
$1,198 Roundtrip, found 4 hours ago
$1,198
Roundtrip
found 4 hours ago
Select LATAM Airlines Group flight, departing Wed, Aug 19 from Des Moines to Cusco, returning Wed, Aug 26, priced at $1,198 found 4 hours ago
LATAM Airlines Group
Tue, Oct 6 - Tue, Oct 13
DSM
Des Moines
CUZ
Cusco
$1,201 Roundtrip, found 12 hours ago
$1,201
Roundtrip
found 12 hours ago
Select LATAM Airlines Group flight, departing Tue, Oct 6 from Des Moines to Cusco, returning Tue, Oct 13, priced at $1,201 found 12 hours ago
United
Sun, Aug 16 - Mon, Aug 24
DSM
Des Moines
CUZ
Cusco
$1,204 Roundtrip, found 1 day ago
$1,204
Roundtrip
found 1 day ago
Select United flight, departing Sun, Aug 16 from Des Moines to Cusco, returning Mon, Aug 24, priced at $1,204 found 1 day ago

Frequently asked questions

How much does a flight from Des Moines, IA (DSM-Des Moines Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.) cost?
You can find cheap one-way flights from $455 and cheap return flights from $899 Des Moines, IA (DSM-Des Moines Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.) with Expedia. Return flights typically cost between $1053 and $3131. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Des Moines, IA (DSM-Des Moines Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Des Moines, IA (DSM-Des Moines Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)?
The cheapest month to fly from DSM to CUZ is October when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Des Moines, IA (DSM-Des Moines Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)?
Enter DSM to CUZ and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
How do I find cheap flights from Des Moines, IA (DSM-Des Moines Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)?
To find a cheap flight from Des Moines, IA (DSM-Des Moines Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Des Moines, IA (DSM-Des Moines Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
What is the earliest flight from Des Moines, IA (DSM-Des Moines Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)?
The earliest flight from Des Moines International Airport (DSM) to Alejandro Velasco Astete International Airport (CUZ) usually leaves at around 5:30 AM. This early departure allows you to maximize your time exploring the beautiful city of Cusco. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Des Moines, IA (DSM-Des Moines Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)?
The most popular departure times for flights from Des Moines (DSM) to Cusco (CUZ) are in the late morning, from 9am to noon. About 42% of passengers prefer this time window. Many major carriers, including Delta, United Airlines, and LATAM Airlines, offer flights during this window. This timing is favored because it allows you to maximize your morning in Des Moines before heading off on your adventure.
How long does it take to fly from Des Moines, IA (DSM-Des Moines Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)?
A flight from DSM to CUZ with a layover takes around 21 hours 20 minutes, with the route covering approximately 4,049 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Des Moines, IA (DSM-Des Moines Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)?
Select the "Business class" and "First class" filters when looking for DSM to CUZ flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip.
How do I earn miles on a Des Moines, IA (DSM-Des Moines Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.) flight with Expedia?
It's easy to earn miles on a Des Moines, IA (DSM-Des Moines Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Cusco from Des Moines Intl. (DSM)?
From Des Moines Intl. (DSM), you can fly typically into Alejandro Velasco Astete Intl. (CUZ) to reach Cusco. Some flights may connect through major hubs like Hartsfield-Jackson Atlanta Intl. (ATL), George Bush Intercontinental (IAH), O'Hare Intl. (ORD) before reaching Cusco. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Des Moines, IA (DSM-Des Moines Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.) at the last minute?
Typically, booking a last minute flight from Des Moines, IA (DSM-Des Moines Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Des Moines, IA (DSM-Des Moines Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.) flight and hotel package?
Securing a Des Moines, IA (DSM-Des Moines Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.) Cusco Vacation Packages is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Des Moines, IA (DSM-Des Moines Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)?
If you booked your Des Moines, IA (DSM-Des Moines Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Des Moines Intl.
Destination airport
Alejandro Velasco Astete Intl.
Airlines serving
Delta, LATAM Airlines Group, avianca
Roundtrip price
$899
Distance
4048 mi

Book with confidence

Des Moines to Cusco Flights

The cheapest times to fly from Des Moines to Cusco

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Cusco are during the month of October. You can find some of the cheapest flights from Des Moines to Cusco with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Cusco

Sunday is one of the best days to book for cheap flights from Des Moines to Cusco: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Cusco

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Cusco in 2026. You can also book with separate airlines for your outbound and return journeys, from $455 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Cusco flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Cusco airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Des Moines to Cusco Flights

*Flight schedules are subject to change.

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*Available to One Key members.