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$269 Cheap Flights from Des Moines (DSM) to Mobile (MOB)

View $269 flight on Fri, Aug 7, 2026Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Mobile Regional Airport (MOB)

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Cheap Flights from Des Moines to Mobile (DSM-MOB)

Prices were available within the past 7 days and start at $269 for one-way flights and $309 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Fri, Aug 14 - Sun, Aug 16
DSM
Des Moines
MOB
Mobile
$309 Roundtrip, found 3 hours ago
$309
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Fri, Aug 14 from Des Moines to Mobile, returning Sun, Aug 16, priced at $309 found 3 hours ago
American Airlines
Tue, Sep 15 - Mon, Sep 21
DSM
Des Moines
MOB
Mobile
$324 Roundtrip, found 4 hours ago
$324
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Tue, Sep 15 from Des Moines to Mobile, returning Mon, Sep 21, priced at $324 found 4 hours ago
United
Fri, Aug 21 - Mon, Aug 24
DSM
Des Moines
MOB
Mobile
$329 Roundtrip, found 1 day ago
$329
Roundtrip
found 1 day ago
Select United flight, departing Fri, Aug 21 from Des Moines to Mobile, returning Mon, Aug 24, priced at $329 found 1 day ago
American Airlines
Wed, Sep 16 - Tue, Sep 22
DSM
Des Moines
MOB
Mobile
$333 Roundtrip, found 4 hours ago
$333
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Wed, Sep 16 from Des Moines to Mobile, returning Tue, Sep 22, priced at $333 found 4 hours ago
Delta
Tue, Sep 15 - Mon, Sep 21
DSM
Des Moines
MOB
Mobile
$334 Roundtrip, found 4 hours ago
$334
Roundtrip
found 4 hours ago
Select Delta flight, departing Tue, Sep 15 from Des Moines to Mobile, returning Mon, Sep 21, priced at $334 found 4 hours ago
United
Fri, Aug 21 - Mon, Aug 24
DSM
Des Moines
MOB
Mobile
$344 Roundtrip, found 1 day ago
$344
Roundtrip
found 1 day ago
Select United flight, departing Fri, Aug 21 from Des Moines to Mobile, returning Mon, Aug 24, priced at $344 found 1 day ago
American Airlines
Wed, Sep 16 - Tue, Sep 22
DSM
Des Moines
MOB
Mobile
$348 Roundtrip, found 4 hours ago
$348
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Wed, Sep 16 from Des Moines to Mobile, returning Tue, Sep 22, priced at $348 found 4 hours ago
United
Wed, Sep 16 - Tue, Sep 22
DSM
Des Moines
MOB
Mobile
$351 Roundtrip, found 4 hours ago
$351
Roundtrip
found 4 hours ago
Select United flight, departing Wed, Sep 16 from Des Moines to Mobile, returning Tue, Sep 22, priced at $351 found 4 hours ago
Delta
Fri, Aug 7 - Sun, Aug 9
DSM
Des Moines
MOB
Mobile
$364 Roundtrip, found 3 hours ago
$364
Roundtrip
found 3 hours ago
Select Delta flight, departing Fri, Aug 7 from Des Moines to Mobile, returning Sun, Aug 9, priced at $364 found 3 hours ago
United
Fri, Aug 21 - Mon, Aug 24
DSM
Des Moines
MOB
Mobile
$366 Roundtrip, found 1 day ago
$366
Roundtrip
found 1 day ago
Select United flight, departing Fri, Aug 21 from Des Moines to Mobile, returning Mon, Aug 24, priced at $366 found 1 day ago

What you need to know for your flight from Des Moines Intl. to Mobile Regional

Des Moines (DSM) to Mobile (MOB) at a glance

Travel from Des Moines (DSM) to Mobile (MOB) with a selection of airlines catering to this domestic short-haul route. Explore various options for cheap flights from Des Moines, allowing you to find an itinerary that aligns with your budget and travel schedule. As you plan your journey, check the key details for flights from Des Moines International Airport to Mobile Regional Airport, and get ready to discover Mobile's renowned attractions and neighborhoods.

  • Fastest flight duration: around 4 hours in-flight, plus roughly 1h 30m layover with one stop
  • Route distance: roughly 800 miles (1,290 km)
  • Flights per week: around 8 departures on average
  • Typical fares (one-way): economy tickets often range from $120–$395, depending on seasonality and how far ahead you book

Flights from Des Moines International Airport (DSM) to Mobile Regional Airport (MOB)

According to recent booking trends, travelers flying from Des Moines to Mobile typically opt for airlines that offer one-stop services, with popular layovers at Dallas-Fort Worth International Airport (DFW, approximately 1 hour 15 minutes), Hartsfield-Jackson Atlanta International Airport (ATL, around 1 hour 30 minutes), and George Bush Intercontinental Airport (IAH, also about 1 hour 30 minutes). This flexibility allows you to tailor your journey by considering price, total travel time, and cabin class to secure the best possible itinerary.

  • American Airlines: This full-service airline provides one-stop flights, with one-way ticket prices generally falling between $120 and $415. It represents about 47% of departures for this route, featuring an in-flight duration of 4 hours and a total travel time of approximately 5 hours and 30 minutes, including layover time.
  • Delta: Another full-service option, Delta offers one-stop flights with one-way fares typically ranging from $120 to $395. It accounts for roughly 32% of departures on this route, boasting an in-flight time of 4 hours and a complete journey time of around 5 hours and 30 minutes when factoring in layovers.
  • United: As a full-service airline, United provides one-stop services with one-way fares usually between $125 and $285. It makes up about 21% of the departures on this route, featuring an in-flight duration of 4 hours and a total travel time of nearly 5 hours and 30 minutes, including layovers.

Alternative route from Des Moines (DSM) to Mobile (MOB)

  • Des Moines to Pensacola (DSM-PNS): Pensacola International Airport (PNS) is located approximately 64 miles from Mobile Regional Airport (MOB). One-way economy fares for this route generally fall between $120 and $410, influenced by the season and how far in advance you make your reservation. Most flights on this route involve one stop, with common layover points being Hartsfield-Jackson Atlanta International Airport (ATL) and Charlotte-Douglas International Airport (CLT). Major airlines operating on this route include American Airlines and Delta. Additionally, first-class service is offered for travelers who prefer a more luxurious experience.

How to find the best prices for flights from Des Moines (DSM) to Mobile (MOB)

Getting some of the best deals on flights from Des Moines to Mobile is all about timing and flexibility. Here are some key tips to help you save:

  1. Best times to book and fly: cheaper fares are usually found when booking 2-8 weeks in advance, which coincides with when most travelers make their reservations. Morning departures, from 5 a.m. to 12 p.m., tend to offer lower prices and are also the most popular. Additionally, flying on Wednesday often provides cheaper rates, although Thursday is the most favored travel day.
  2. Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
  3. Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.*
  4. Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
  5. Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
  6. Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.

*Members only. Savings vary and are not available on all bundles. Select hotels.

Arriving at Mobile Regional Airport from Des Moines International Airport

Mobile welcomes travelers from Des Moines with a range of transport options based on price, convenience, and proximity. Here's how to reach Mobile efficiently:

  • Hotel transfer: Transfers offer a convenient way to reach your hotel in Mobile, with options including free hotel shuttles and private rides, which can be arranged in advance with your hotel.
  • Car rental: Renting a car from Mobile Regional Airport is a great option if you plan to explore and sightsee beyond the city. Browse cheap car rentals at Mobile Regional Airport on Expedia.
  • Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.

Frequently asked questions

How much does a flight from Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional) cost?
You can find cheap one-way flights from $269 and cheap return flights from $309 Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional) with Expedia. One-way flights usually range from $336 to $645, and return flights typically cost between $311 and $1025. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional)?
April is the cheapest month to fly from Des Moines (DSM) to Mobile (MOB), with average round-trip fares around $279. This is about 26% lower than the average price for the year, as demand tends to drop in spring. Other affordable months include October and December.*Averages based on flights available on Expedia in the last year.
Which airlines fly direct from Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional)?
Enter DSM to MOB and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional)?
American Airlines is one of the cheapest airlines offering connecting flights from Des Moines International Airport (DSM) to Mobile, AL (MOB), with return tickets starting from around $248 with a layover in O'Hare International (ORD). Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional)?
To find a cheap flight from Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional)?
When flying from Des Moines to Mobile, April and December are the best months. You can find return flights for about $279, making it a cost-effective choice. April is popular for spring travel, while December offers a festive atmosphere during the holidays.*Prices based on flights available on Expedia in the last year.
What is the earliest flight from Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional)?
The earliest flight from Des Moines International Airport (DSM) to Mobile Regional Airport (MOB) typically departs at 5:00 AM, operated by American Airlines. This seasonal service is available in November and December, allowing you to start your day early in Mobile. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional)?
The most popular departure times for flights from Des Moines, IA (DSM) to Mobile, AL (MOB) are in the early morning, from 6am to 9am. About 28% of passengers prefer this time window. United Airlines and American Airlines both offer flights during this window. Many travelers choose this time to ensure they have a full day ahead upon arrival in Mobile.
How long does it take to fly from Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional)?
A flight from DSM to MOB with a layover takes around 7 hours, with the route covering approximately 808 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional)?
First class seats are offered on the DSM to MOB route. First class cabins are available on:

  • Delta Air Lines
  • American Airlines
  • United Airlines

How do I earn miles on a Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional) flight with Expedia?
It's easy to earn miles on a Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Mobile from Des Moines Intl. (DSM)?
If you're planning to travel to Mobile from Des Moines Intl. (DSM), you can fly into Mobile Regional (MOB) Some flights may connect through major hubs like O'Hare Intl. (ORD), Denver Intl. (DEN), LaGuardia (LGA) before reaching Mobile. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional) at the last minute?
Typically, booking a last minute flight from Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional) flight and hotel package?
Securing a Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional)?
If you booked your Des Moines, IA (DSM-Des Moines Intl.) to Mobile, AL (MOB-Mobile Regional) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Des Moines Intl.
Destination airport
Mobile Regional
Airlines serving
American Airlines, Delta, United
Roundtrip price
$308
Distance
807 mi

Book with confidence

Des Moines to Mobile Flights

The cheapest times to fly from Des Moines to Mobile

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Mobile are during the month of August. You can find some of the cheapest flights from Des Moines to Mobile with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Mobile

Sunday is one of the best days to book for cheap flights from Des Moines to Mobile: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Mobile

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Mobile in 2026. You can also book with separate airlines for your outbound and return journeys, from $269 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Mobile flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Mobile airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Des Moines to Mobile Flights

*Flight schedules are subject to change.

*Available to One Key members.

 

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