$190 Cheap Flights from Knoxville (TYS) to Mobile (MOB)

View $190 flight on Wed, Aug 26, 2026Opens in a new window

Popular airlines from McGhee Tyson Airport (TYS) to Mobile Regional Airport (MOB)

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Cheap Flights from Knoxville to Mobile (TYS-MOB)

Prices were available within the past 7 days and start at $190 for one-way flights and $367 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Thu, May 28 - Mon, Jun 1
TYS
Knoxville
MOB
Mobile
$367 Roundtrip, found 3 days ago
$367
Roundtrip
found 3 days ago
Select Delta flight, departing Thu, May 28 from Knoxville to Mobile, returning Mon, Jun 1, priced at $367 found 3 days ago
Delta
Thu, May 21 - Fri, May 29
TYS
Knoxville
MOB
Mobile
$377 Roundtrip, found 6 days ago
$377
Roundtrip
found 6 days ago
Select Delta flight, departing Thu, May 21 from Knoxville to Mobile, returning Fri, May 29, priced at $377 found 6 days ago
Delta
Sun, May 31 - Thu, Jun 4
TYS
Knoxville
MOB
Mobile
$379 Roundtrip, found 1 day ago
$379
Roundtrip
found 1 day ago
Select Delta flight, departing Sun, May 31 from Knoxville to Mobile, returning Thu, Jun 4, priced at $379 found 1 day ago
Delta
Thu, May 21 - Mon, May 25
TYS
Knoxville
MOB
Mobile
$387 Roundtrip, found 1 day ago
$387
Roundtrip
found 1 day ago
Select Delta flight, departing Thu, May 21 from Knoxville to Mobile, returning Mon, May 25, priced at $387 found 1 day ago
Delta
Sat, May 23 - Wed, May 27
TYS
Knoxville
MOB
Mobile
$397 Roundtrip, found 6 days ago
$397
Roundtrip
found 6 days ago
Select Delta flight, departing Sat, May 23 from Knoxville to Mobile, returning Wed, May 27, priced at $397 found 6 days ago
Delta
Thu, May 28 - Mon, Jun 1
TYS
Knoxville
MOB
Mobile
$399 Roundtrip, found 3 days ago
$399
Roundtrip
found 3 days ago
Select Delta flight, departing Thu, May 28 from Knoxville to Mobile, returning Mon, Jun 1, priced at $399 found 3 days ago
Delta
Mon, Oct 5 - Mon, Oct 12
TYS
Knoxville
MOB
Mobile
$403 Roundtrip, found 1 day ago
$403
Roundtrip
found 1 day ago
Select Delta flight, departing Mon, Oct 5 from Knoxville to Mobile, returning Mon, Oct 12, priced at $403 found 1 day ago
Delta
Thu, May 28 - Thu, Jun 4
TYS
Knoxville
MOB
Mobile
$407 Roundtrip, found 15 hours ago
$407
Roundtrip
found 15 hours ago
Select Delta flight, departing Thu, May 28 from Knoxville to Mobile, returning Thu, Jun 4, priced at $407 found 15 hours ago
American Airlines
Tue, May 12 - Tue, May 19
TYS
Knoxville
MOB
Mobile
$417 Roundtrip, found 3 days ago
$417
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, May 12 from Knoxville to Mobile, returning Tue, May 19, priced at $417 found 3 days ago
United
Thu, May 28 - Mon, Jun 1
TYS
Knoxville
MOB
Mobile
$737 Roundtrip, found 3 days ago
$737
Roundtrip
found 3 days ago
Select United flight, departing Thu, May 28 from Knoxville to Mobile, returning Mon, Jun 1, priced at $737 found 3 days ago

Frequently asked questions

How much does a flight from Knoxville, TN (TYS-McGhee Tyson) to Mobile, AL (MOB-Mobile Regional) cost?
You can find cheap one-way flights and cheap return flights from $367 Knoxville, TN (TYS-McGhee Tyson) to Mobile, AL (MOB-Mobile Regional) with Expedia. One-way flights usually range from $359 to $981, and return flights typically cost between $555 and $1549. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Knoxville, TN (TYS-McGhee Tyson) to Mobile, AL (MOB-Mobile Regional) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Knoxville, TN (TYS-McGhee Tyson) to Mobile, AL (MOB-Mobile Regional)?
The cheapest month to fly from TYS to MOB is May when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Knoxville, TN (TYS-McGhee Tyson) to Mobile, AL (MOB-Mobile Regional)?
Enter TYS to MOB and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Knoxville, TN (TYS-McGhee Tyson) to Mobile, AL (MOB-Mobile Regional)?
American Airlines is one of the cheapest airlines offering connecting flights from McGhee Tyson (TYS) to Mobile Regional (MOB), with round-trip tickets starting from around $742. Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Knoxville, TN (TYS-McGhee Tyson) to Mobile, AL (MOB-Mobile Regional)?
To find a cheap flight from Knoxville, TN (TYS-McGhee Tyson) to Mobile, AL (MOB-Mobile Regional), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Knoxville, TN (TYS-McGhee Tyson) to Mobile, AL (MOB-Mobile Regional)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
What is the earliest flight from Knoxville, TN (TYS-McGhee Tyson) to Mobile, AL (MOB-Mobile Regional)?
The earliest flight from Knoxville (TYS) to Mobile (MOB) usually leaves at 5:05 AM, operated by American Airlines. This is a seasonal service available in November. An early flight can help you maximize your time in Mobile. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Knoxville, TN (TYS-McGhee Tyson) to Mobile, AL (MOB-Mobile Regional)?
For flights from Knoxville (TYS) to Mobile (MOB), the most popular departure times are from 9am to 12pm. This time window captures about 23% of total traffic. Major carriers like United Airlines, Delta Air Lines, and American Airlines operate flights during this period. This timing is popular because it allows travelers to start their day early and arrive in Mobile by midday.
How long does it take to fly from Knoxville, TN (TYS-McGhee Tyson) to Mobile, AL (MOB-Mobile Regional)?
Flying from TYS to MOB with a connection usually takes about 5 hours 30 minutes, traveling roughly 431 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Knoxville, TN (TYS-McGhee Tyson) to Mobile, AL (MOB-Mobile Regional)?
First class seats are offered on the TYS to MOB route with Delta Air Lines and American Airlines.
How do I earn miles on a Knoxville, TN (TYS-McGhee Tyson) to Mobile, AL (MOB-Mobile Regional) flight with Expedia?
It's easy to earn miles on a Knoxville, TN (TYS-McGhee Tyson) to Mobile, AL (MOB-Mobile Regional) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Mobile from McGhee Tyson (TYS)?
If you're planning to travel to Mobile from McGhee Tyson (TYS), you can fly into Mobile Regional (MOB) Some flights may connect through major hubs like O'Hare Intl. (ORD), LaGuardia (LGA), Miami Intl. (MIA) before reaching Mobile. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Knoxville, TN (TYS-McGhee Tyson) to Mobile, AL (MOB-Mobile Regional) at the last minute?
Typically, booking a last minute flight from Knoxville, TN (TYS-McGhee Tyson) to Mobile, AL (MOB-Mobile Regional) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Knoxville, TN (TYS-McGhee Tyson) to Mobile, AL (MOB-Mobile Regional) flight and hotel package?
Securing a Knoxville, TN (TYS-McGhee Tyson) to Mobile, AL (MOB-Mobile Regional) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Knoxville, TN (TYS-McGhee Tyson) to Mobile, AL (MOB-Mobile Regional)?
If you booked your Knoxville, TN (TYS-McGhee Tyson) to Mobile, AL (MOB-Mobile Regional) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
McGhee Tyson
Destination airport
Mobile Regional
Airlines serving
American Airlines, Delta, United
Roundtrip price
$366
Distance
430 mi

Book with confidence

Knoxville to Mobile Flights

The cheapest times to fly from Knoxville to Mobile

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Knoxville to Mobile are during the month of May. You can find some of the cheapest flights from Knoxville to Mobile with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Knoxville to Mobile

Sunday is one of the best days to book for cheap flights from Knoxville to Mobile: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Knoxville to Mobile

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Knoxville to Mobile in 2026. You can also book with separate airlines for your outbound and return journeys, from $190 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Knoxville to Mobile flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Knoxville to Mobile airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Knoxville to Mobile Flights

*Flight schedules are subject to change.

*Available to One Key members.

 

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