$266 Cheap Flights from Sioux Falls (FSD) to Florence (FLO)

View $266 flight on Tue, May 5, 2026Opens in a new window

Popular airlines from Sioux Falls Regional Airport (FSD) to Florence, SC (FLO-Florence Regional)

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Cheap Flights from Sioux Falls to Florence (FSD-FLO)

Prices were available within the past 7 days and start at $266 for one-way flights and $505 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Apr 1 - Sat, Apr 4
FSD
Sioux Falls
FLO
Florence
$505 Roundtrip, found 1 day ago
$505
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Apr 1 from Sioux Falls to Florence, returning Sat, Apr 4, priced at $505 found 1 day ago
American Airlines
Wed, Apr 1 - Sat, Apr 4
FSD
Sioux Falls
FLO
Florence
$527 Roundtrip, found 1 day ago
$527
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Apr 1 from Sioux Falls to Florence, returning Sat, Apr 4, priced at $527 found 1 day ago
American Airlines
Tue, May 5 - Fri, May 8
FSD
Sioux Falls
FLO
Florence
$578 Roundtrip, found 5 days ago
$578
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, May 5 from Sioux Falls to Florence, returning Fri, May 8, priced at $578 found 5 days ago
American Airlines
Tue, May 5 - Fri, May 8
FSD
Sioux Falls
FLO
Florence
$590 Roundtrip, found 5 days ago
$590
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, May 5 from Sioux Falls to Florence, returning Fri, May 8, priced at $590 found 5 days ago
American Airlines
Wed, Apr 1 - Sat, Apr 4
FSD
Sioux Falls
FLO
Florence
$601 Roundtrip, found 1 day ago
$601
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Apr 1 from Sioux Falls to Florence, returning Sat, Apr 4, priced at $601 found 1 day ago
American Airlines
Tue, May 5 - Fri, May 8
FSD
Sioux Falls
FLO
Florence
$608 Roundtrip, found 5 days ago
$608
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, May 5 from Sioux Falls to Florence, returning Fri, May 8, priced at $608 found 5 days ago
American Airlines
Tue, May 5 - Fri, May 8
FSD
Sioux Falls
FLO
Florence
$619 Roundtrip, found 5 days ago
$619
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, May 5 from Sioux Falls to Florence, returning Fri, May 8, priced at $619 found 5 days ago
American Airlines
Wed, Apr 1 - Sat, Apr 4
FSD
Sioux Falls
FLO
Florence
$623 Roundtrip, found 1 day ago
$623
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Apr 1 from Sioux Falls to Florence, returning Sat, Apr 4, priced at $623 found 1 day ago
American Airlines
Tue, May 5 - Fri, May 8
FSD
Sioux Falls
FLO
Florence
$631 Roundtrip, found 5 days ago
$631
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, May 5 from Sioux Falls to Florence, returning Fri, May 8, priced at $631 found 5 days ago
American Airlines
Tue, May 5 - Fri, May 8
FSD
Sioux Falls
FLO
Florence
$634 Roundtrip, found 5 days ago
$634
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, May 5 from Sioux Falls to Florence, returning Fri, May 8, priced at $634 found 5 days ago

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Frequently asked questions

How much does a flight from Sioux Falls, SD (FSD-Sioux Falls Regional) to Florence, SC (FLO-Florence Regional) cost?
You can find cheap one-way flights from $266 and cheap return flights from $505 Sioux Falls, SD (FSD-Sioux Falls Regional) to Florence, SC (FLO-Florence Regional) with Expedia. One-way flights usually range from $494 to $558, and return flights typically cost between $574 and $1234. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Sioux Falls, SD (FSD-Sioux Falls Regional) to Florence, SC (FLO-Florence Regional) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Sioux Falls, SD (FSD-Sioux Falls Regional) to Florence, SC (FLO-Florence Regional)?
The cheapest month to fly from FSD to FLO is April when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Sioux Falls, SD (FSD-Sioux Falls Regional) to Florence, SC (FLO-Florence Regional)?
Enter FSD to FLO and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Sioux Falls, SD (FSD-Sioux Falls Regional) to Florence, SC (FLO-Florence Regional)?
American Airlines is one of the cheapest airlines offering connecting flights from Sioux Falls, SD (FSD) to Florence, SC (FLO), with round-trip tickets starting from around $434 with a layover in Dallas-Fort Worth Intl. (DFW). Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Sioux Falls, SD (FSD-Sioux Falls Regional) to Florence, SC (FLO-Florence Regional)?
To find a cheap flight from Sioux Falls, SD (FSD-Sioux Falls Regional) to Florence, SC (FLO-Florence Regional), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Sioux Falls, SD (FSD-Sioux Falls Regional) to Florence, SC (FLO-Florence Regional)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
What is the earliest flight from Sioux Falls, SD (FSD-Sioux Falls Regional) to Florence, SC (FLO-Florence Regional)?
The earliest flight from Sioux Falls Regional (FSD) to Florence Regional (FLO) typically departs at around 5:15 AM, operated by American Airlines. This service is seasonal and active in May, allowing you to start your day early and make the most of your time in Florence. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Sioux Falls, SD (FSD-Sioux Falls Regional) to Florence, SC (FLO-Florence Regional)?
The most popular departure times for flights from Sioux Falls (FSD) to Florence (FLO) are in the early morning, from 6am to 9am. About 55% of passengers prefer this time window. Many major carriers, including American Airlines, operate flights during this window. This timing works well because it allows travelers to start their day early and arrive in Florence with plenty of time to explore.
How long does it take to fly from Sioux Falls, SD (FSD-Sioux Falls Regional) to Florence, SC (FLO-Florence Regional)?
Flights from FSD to FLO with one stop typically take around 10 hours, covering approximately 1,118 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Sioux Falls, SD (FSD-Sioux Falls Regional) to Florence, SC (FLO-Florence Regional)?
Select the "Business class" and "First class" filters when looking for FSD to FLO flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip.
How do I earn miles on a Sioux Falls, SD (FSD-Sioux Falls Regional) to Florence, SC (FLO-Florence Regional) flight with Expedia?
It's easy to earn miles on a Sioux Falls, SD (FSD-Sioux Falls Regional) to Florence, SC (FLO-Florence Regional) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Florence from Sioux Falls Regional (FSD)?
When traveling from Sioux Falls Regional (FSD) to Florence, you can fly into Florence Regional (FLO) and Peretola (FLR). Some flights may connect through major hubs like O'Hare Intl. (ORD), Dallas-Fort Worth Intl. (DFW) before reaching Florence. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Sioux Falls, SD (FSD-Sioux Falls Regional) to Florence, SC (FLO-Florence Regional) at the last minute?
Typically, booking a last minute flight from Sioux Falls, SD (FSD-Sioux Falls Regional) to Florence, SC (FLO-Florence Regional) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Sioux Falls, SD (FSD-Sioux Falls Regional) to Florence, SC (FLO-Florence Regional) flight and hotel package?
Securing a Sioux Falls, SD (FSD-Sioux Falls Regional) to Florence, SC (FLO-Florence Regional) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Sioux Falls, SD (FSD-Sioux Falls Regional) to Florence, SC (FLO-Florence Regional)?
If you booked your Sioux Falls, SD (FSD-Sioux Falls Regional) to Florence, SC (FLO-Florence Regional) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Sioux Falls Regional
Destination airport
Florence Regional
Roundtrip price
$504
Distance
1117 mi

Book with confidence

Sioux Falls to Florence Flights

The cheapest times to fly from Sioux Falls to Florence

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Sioux Falls to Florence are during the month of April. You can find some of the cheapest flights from Sioux Falls to Florence with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Sioux Falls to Florence

Sunday is one of the best days to book for cheap flights from Sioux Falls to Florence: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Sioux Falls to Florence

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Sioux Falls to Florence in 2026. You can also book with separate airlines for your outbound and return journeys, from $266 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Sioux Falls to Florence flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Sioux Falls to Florence airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Sioux Falls to Florence Flights

*Flight schedules are subject to change.

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