$255 Cheap Flights from Greenville (GSP) to La Crosse (LSE)

View $255 flight on Fri, Dec 19, 2025Opens in a new window

Popular airlines from Greenville-Spartanburg Intl. Airport (GSP) to La Crosse, WI (LSE-La Crosse Municipal)

Cheap Flights from Greenville to La Crosse (GSP-LSE)

Prices were available within the past 7 days and start at $255 for one-way flights and $541 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Thu, Aug 20 - Mon, Aug 24
GSP
Greenville
LSE
La Crosse
$541 Roundtrip, found 1 day ago
$541
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Aug 20 from Greenville to La Crosse, returning Mon, Aug 24, priced at $541 found 1 day ago
American Airlines
Mon, Dec 22 - Thu, Jan 1
GSP
Greenville
LSE
La Crosse
$561 Roundtrip, found 4 days ago
$561
Roundtrip
found 4 days ago
Select American Airlines flight, departing Mon, Dec 22 from Greenville to La Crosse, returning Thu, Jan 1, priced at $561 found 4 days ago
American Airlines
Thu, Dec 25 - Sat, Jan 3
GSP
Greenville
LSE
La Crosse
$563 Roundtrip, found 4 days ago
$563
Roundtrip
found 4 days ago
Select American Airlines flight, departing Thu, Dec 25 from Greenville to La Crosse, returning Sat, Jan 3, priced at $563 found 4 days ago
American Airlines
Thu, Aug 20 - Mon, Aug 24
GSP
Greenville
LSE
La Crosse
$565 Roundtrip, found 1 day ago
$565
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Aug 20 from Greenville to La Crosse, returning Mon, Aug 24, priced at $565 found 1 day ago
American Airlines
Mon, Dec 22 - Tue, Jan 6
GSP
Greenville
LSE
La Crosse
$570 Roundtrip, found 4 days ago
$570
Roundtrip
found 4 days ago
Select American Airlines flight, departing Mon, Dec 22 from Greenville to La Crosse, returning Tue, Jan 6, priced at $570 found 4 days ago
American Airlines
Thu, Dec 25 - Sat, Jan 3
GSP
Greenville
LSE
La Crosse
$575 Roundtrip, found 4 days ago
$575
Roundtrip
found 4 days ago
Select American Airlines flight, departing Thu, Dec 25 from Greenville to La Crosse, returning Sat, Jan 3, priced at $575 found 4 days ago
American Airlines
Wed, Dec 24 - Thu, Jan 1
GSP
Greenville
LSE
La Crosse
$580 Roundtrip, found 4 days ago
$580
Roundtrip
found 4 days ago
Select American Airlines flight, departing Wed, Dec 24 from Greenville to La Crosse, returning Thu, Jan 1, priced at $580 found 4 days ago
American Airlines
Thu, Dec 25 - Sat, Jan 3
GSP
Greenville
LSE
La Crosse
$589 Roundtrip, found 4 days ago
$589
Roundtrip
found 4 days ago
Select American Airlines flight, departing Thu, Dec 25 from Greenville to La Crosse, returning Sat, Jan 3, priced at $589 found 4 days ago
American Airlines
Thu, Dec 25 - Sat, Jan 3
GSP
Greenville
LSE
La Crosse
$592 Roundtrip, found 4 days ago
$592
Roundtrip
found 4 days ago
Select American Airlines flight, departing Thu, Dec 25 from Greenville to La Crosse, returning Sat, Jan 3, priced at $592 found 4 days ago
American Airlines
Mon, Dec 22 - Sun, Jan 4
GSP
Greenville
LSE
La Crosse
$594 Roundtrip, found 4 days ago
$594
Roundtrip
found 4 days ago
Select American Airlines flight, departing Mon, Dec 22 from Greenville to La Crosse, returning Sun, Jan 4, priced at $594 found 4 days ago

Frequently asked questions

How much does a flight from Greenville-Spartanburg Intl. Airport (GSP) to La Crosse Municipal Airport (LSE) cost?
Lock in a cheap one-way flight from $255 or cheap return flight from $541 from Greenville-Spartanburg Intl. Airport (GSP) to La Crosse Municipal Airport (LSE) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Greenville-Spartanburg Intl. Airport (GSP) to La Crosse Municipal Airport (LSE)?
August is the cheapest month to fly from GSP to LSE. Planning your trip for the off-season is often the key to finding better deals on flights.
What is the cheapest airline that flies from Greenville-Spartanburg Intl. Airport (GSP) to La Crosse Municipal Airport (LSE)?
Expedia's filter tool lets you easily compare different airlines, flight durations and fares all in one place. Choose your preferences, then sort by "Price (lowest to highest)" to find out which carrier offers the cheapest GSP to LSE flight.
How many flights per day from Greenville-Spartanburg Intl. Airport (GSP) to La Crosse Municipal Airport (LSE)?
There aren't any daily direct flights from Greenville-Spartanburg Intl. Airport (GSP) to La Crosse Municipal Airport (LSE). But you can opt for flights with layovers. Filter your search on Expedia to include one or two stops, and you'll be on your way in no time.
What day of the week has the most flights from GSP to LSE?
Friday is generally the busiest day for flights, while Tuesday tends to be the quietest.* Remember that flight schedules can vary depending on a number of factors, such as the time of year and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Greenville-Spartanburg Intl. Airport (GSP) to La Crosse Municipal Airport (LSE)?
Choose a flight from Greenville-Spartanburg Intl. Airport (GSP) to La Crosse Municipal Airport (LSE) that takes off before 3 PM to reduce the likelihood of delays and cancellations. Departures later than this are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Greenville-Spartanburg Intl. Airport (GSP) to La Crosse Municipal Airport (LSE) last-minute?
Booking your flight from GSP to LSE just before your trip is generally more expensive. But if you're flexible with your schedule, you could bag a cheap last-minute fare.
Is it cheaper to book a GSP to LSE flight and hotel package?
Compared with arranging hotels and flights separately, booking a GSP to LSE flight and hotel package with Expedia could result in significant savings. Better yet, managing everything in one place takes the hassle out of travel planning. Just secure your flights and choose from our wide range of stays, then personalize your trip with extras like tours, activities and car rentals.
Can I cancel or change the date of my flight from Greenville-Spartanburg Intl. Airport (GSP) to La Crosse Municipal Airport (LSE)?
If you booked your GSP to LSE flight in the last 24 hours, you may be able to cancel or modify it at no cost. Depending on the airline and the type of fare you purchased, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal for more information.

Travel information

Origin airport
Greenville-Spartanburg Intl.
Destination airport
La Crosse Municipal
Roundtrip price
$541
Distance
785 mi

Book with confidence

Greenville to La Crosse Flights

The cheapest times to fly from Greenville to La Crosse

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Greenville to La Crosse are during the month of August. You can find some of the cheapest flights from Greenville to La Crosse with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Greenville to La Crosse

Sunday is one of the best days to book for cheap flights from Greenville to La Crosse: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Greenville to La Crosse

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Greenville to La Crosse in 2025. You can also book with separate airlines for your outbound and return journeys, from $255 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Greenville to La Crosse flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Greenville to La Crosse airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Greenville to La Crosse Flights

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*Available to One Key members.