$457 Cheap Flights from Medellín (MDE) to Zacatecas (ZCL)

View $457 flight on Wed, Jan 14, 2026Opens in a new window

Popular airlines from Jose Maria Cordova Intl. Airport (MDE) to Zacatecas, Zacatecas (ZCL-General Leobardo C. Ruiz Intl.)

Cheap Flights from Medellín to Zacatecas (MDE-ZCL)

Prices were available within the past 7 days and start at $457 for one-way flights and $1,512 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Aeromexico
Fri, Oct 31 - Tue, Nov 4
MDE
Medellin
ZCL
Zacatecas
$1,512 Roundtrip, found 4 days ago
$1,512
Roundtrip
found 4 days ago
Select Aeromexico flight, departing Fri, Oct 31 from Medellin to Zacatecas, returning Tue, Nov 4, priced at $1,512 found 4 days ago

Frequently asked questions

How much does a flight from Jose Maria Cordova Intl. Airport (MDE) to General Leobardo C. Ruiz Intl. Airport (ZCL) cost?
Grab a cheap one-way flight from $457 or cheap return flight from $1,512 from Jose Maria Cordova Intl. Airport (MDE) to General Leobardo C. Ruiz Intl. Airport (ZCL) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Jose Maria Cordova Intl. Airport (MDE) to General Leobardo C. Ruiz Intl. Airport (ZCL)?
October is the least expensive month to fly from MDE to ZCL. Timing your trip outside of the busy season is often the key to finding better fares.
What is the cheapest airline that flies from Jose Maria Cordova Intl. Airport (MDE) to General Leobardo C. Ruiz Intl. Airport (ZCL)?
Use the filters on Expedia to compare airlines and find the cheapest carrier that'll fly you from MDE to ZCL. Then, sort your results by "Price (lowest to highest)" to pick up a great deal.
How many flights per day from Jose Maria Cordova Intl. Airport (MDE) to General Leobardo C. Ruiz Intl. Airport (ZCL)?
There aren't any daily nonstop flights departing from Jose Maria Cordova Intl. Airport (MDE) to General Leobardo C. Ruiz Intl. Airport (ZCL). But you can opt for flights with layovers. Filter your search on Expedia to include one or more stops, and you'll be soaring above the clouds in no time at all.
What day of the week has the most flights from MDE to ZCL?
Friday is typically the busiest day for flights, while Tuesday is often the quietest.* Just remember that flight schedules can vary depending on a range of factors, such as the time of year and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Jose Maria Cordova Intl. Airport (MDE) to General Leobardo C. Ruiz Intl. Airport (ZCL)?
To avoid potential delays on the Jose Maria Cordova Intl. Airport (MDE) to General Leobardo C. Ruiz Intl. Airport (ZCL) route, travel before 3 PM. Departures after this hour are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Jose Maria Cordova Intl. Airport (MDE) to General Leobardo C. Ruiz Intl. Airport (ZCL) last-minute?
Booking your flight from MDE to ZCL just before your trip is usually more expensive. However, if you're flexible with your itinerary, you could land a cheap last-minute fare.
Is it cheaper to book a MDE to ZCL flight and hotel package?
Opting for a MDE to ZCL flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Pick from our wide range of stays and then add flights, car rentals and activities to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Jose Maria Cordova Intl. Airport (MDE) to General Leobardo C. Ruiz Intl. Airport (ZCL)?
If you reserved your MDE to ZCL flight in the last 24 hours, you may be able to modify or cancel it at no cost. Depending on the airline and the ticket type you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal for more information.

Travel information

Origin airport
José María Córdova Intl.
Destination airport
General Leobardo C. Ruiz Intl.
Roundtrip price
$1,511
Distance
2150 mi

Book with confidence

Medellín to Zacatecas Flights

The cheapest times to fly from Medellín to Zacatecas

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Medellín to Zacatecas are during the month of October. You can find some of the cheapest flights from Medellín to Zacatecas with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Medellín to Zacatecas

Sunday is one of the best days to book for cheap flights from Medellín to Zacatecas: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Medellín to Zacatecas

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Medellín to Zacatecas in 2025. You can also book with separate airlines for your outbound and return journeys, from $457 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Medellín to Zacatecas flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Medellín to Zacatecas airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Medellín to Zacatecas Flights

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*Available to One Key members.