$120 Cheap Flights from Chicago (MDW) to Knoxville (TYS)

View $120 flight on Sun, Oct 26, 2025Opens in a new window

Popular airlines from Chicago Midway Airport (MDW) to McGhee Tyson Airport (TYS)

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Cheap Flights from Chicago to Knoxville (MDW-TYS)

Prices were available within the past 7 days and start at $120 for one-way flights and $209 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Thu, Sep 4 - Tue, Sep 9
MDW
Chicago
TYS
Knoxville
$209 Roundtrip, found 1 hour ago
$209
Roundtrip
found 1 hour ago
Select Delta flight, departing Thu, Sep 4 from Chicago to Knoxville, returning Tue, Sep 9, priced at $209 found 1 hour ago
Delta
Wed, Aug 13 - Tue, Aug 19
MDW
Chicago
TYS
Knoxville
$214 Roundtrip, found 2 hours ago
$214
Roundtrip
found 2 hours ago
Select Delta flight, departing Wed, Aug 13 from Chicago to Knoxville, returning Tue, Aug 19, priced at $214 found 2 hours ago
Frontier Airlines
Sat, Aug 9 - Sun, Aug 17
MDW
Chicago
TYS
Knoxville
$218 Roundtrip, found 5 hours ago
$218
Roundtrip
found 5 hours ago
Select Frontier Airlines flight, departing Sat, Aug 9 from Chicago to Knoxville, returning Sun, Aug 17, priced at $218 found 5 hours ago
Frontier Airlines
Sun, Oct 12 - Thu, Oct 16
MDW
Chicago
TYS
Knoxville
$228 Roundtrip, found 14 hours ago
$228
Roundtrip
found 14 hours ago
Select Frontier Airlines flight, departing Sun, Oct 12 from Chicago to Knoxville, returning Thu, Oct 16, priced at $228 found 14 hours ago
Delta
Sat, Aug 23 - Mon, Aug 25
MDW
Chicago
TYS
Knoxville
$234 Roundtrip, found 1 hour ago
$234
Roundtrip
found 1 hour ago
Select Delta flight, departing Sat, Aug 23 from Chicago to Knoxville, returning Mon, Aug 25, priced at $234 found 1 hour ago
Delta
Tue, Aug 12 - Mon, Aug 25
MDW
Chicago
TYS
Knoxville
$239 Roundtrip, found 19 hours ago
$239
Roundtrip
found 19 hours ago
Select Delta flight, departing Tue, Aug 12 from Chicago to Knoxville, returning Mon, Aug 25, priced at $239 found 19 hours ago
Delta
Tue, Aug 5 - Tue, Aug 12
MDW
Chicago
TYS
Knoxville
$244 Roundtrip, found 1 hour ago
$244
Roundtrip
found 1 hour ago
Select Delta flight, departing Tue, Aug 5 from Chicago to Knoxville, returning Tue, Aug 12, priced at $244 found 1 hour ago
Frontier Airlines
Sat, Aug 2 - Sun, Oct 12
MDW
Chicago
TYS
Knoxville
$248 Roundtrip, found 1 day ago
$248
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Sat, Aug 2 from Chicago to Knoxville, returning Sun, Oct 12, priced at $248 found 1 day ago
Frontier Airlines
Sat, Aug 2 - Sun, Aug 10
MDW
Chicago
TYS
Knoxville
$258 Roundtrip, found 1 hour ago
$258
Roundtrip
found 1 hour ago
Select Frontier Airlines flight, departing Sat, Aug 2 from Chicago to Knoxville, returning Sun, Aug 10, priced at $258 found 1 hour ago
Delta
Thu, Sep 4 - Tue, Sep 9
MDW
Chicago
TYS
Knoxville
$263 Roundtrip, found 1 hour ago
$263
Roundtrip
found 1 hour ago
Select Delta flight, departing Thu, Sep 4 from Chicago to Knoxville, returning Tue, Sep 9, priced at $263 found 1 hour ago

Find the cheapest month to fly from Chicago (MDW) to Knoxville (TYS)

January is typically the cheapest month to fly

From $128 - $657 per traveler.

Graph displaying average flight prices per month

Alternative airports near Knoxville

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to McGhee Tyson TYS. Cheapest and Closest option available. Average driving time to city center is 22 minutes. Flights from $214
TYS
McGhee Tyson
CheapestClosest
Average driving time to city center22 min
Flights from $214
Flights from Chicago (MDW) to Knoxville (TYS)
Origin airport
Midway Intl.
Destination airport
McGhee Tyson
Airlines serving
Delta, Frontier Airlines
Roundtrip price
$208
Distance
459 mi
Average flight time
1 hour 26 mins

Chicago to Knoxville Flights

The cheapest times to fly from Chicago to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Chicago to Knoxville are during the month of September. You can find some of the cheapest flights from Chicago to Knoxville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Chicago to Knoxville

Sunday is one of the best days to book for cheap flights from Chicago to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Chicago to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Chicago to Knoxville in 2025. You can also book with separate airlines for your outbound and return journeys, from $120 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Chicago to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Chicago to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Midway Intl. Airport (MDW) to McGhee Tyson Airport (TYS) cost?
Discover the latest flight deals from MDW to TYS by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from MDW to TYS?
The cheapest flights from MDW to TYS are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from Midway Intl. Airport (MDW) to McGhee Tyson Airport (TYS)?
There are no direct routes from Chicago, IL (MDW-Midway Intl.) to McGhee Tyson Airport (TYS). However, you can find other airports that offer nonstop flights. Begin your journey at O'Hare Intl. Airport (ORD) and fly straight to Knoxville without layovers.
What is the cheapest airline that flies from MDW to TYS?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from MDW to TYS. Sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from Midway Intl. Airport (MDW) to McGhee Tyson Airport (TYS)?
There are no daily direct flights available from Midway Intl. Airport (MDW) to McGhee Tyson Airport (TYS). But you can book flights with layovers. Filter your search on Expedia to include one or more stops, and you'll be soaring above the clouds in no time at all.
What day of the week has the most flights from MDW to TYS?
Usually you'll find the largest variety of flight choices on a Friday. Tuesdays are often the quietest.* However, this can vary based on the airline, season and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Midway Intl. Airport (MDW) to McGhee Tyson Airport (TYS)?
To arrive at McGhee Tyson Airport (TYS) on time, pick a flight that takes off from Midway Intl. Airport (MDW) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Midway Intl. Airport (MDW) to McGhee Tyson Airport (TYS) last-minute?
Last-minute bookings from MDW to TYS are typically more expensive. To secure the best rates, start looking for flights early. That said, if you can play around with your travel dates, it's possible to land a cheap ticket right before your journey.
Is it cheaper to book a MDW to TYS flight and hotel package?
Compared with arranging flights and hotels separately, booking a MDW to TYS flight and hotel package with Expedia could result in significant savings. What's more, having it all in one place takes the hassle out of planning your trip. Just pick your flights and choose from our wide range of hotels, then tailor your trip with extras like tours, activities and car rentals.
Can I cancel or change the date of my flight from Midway Intl. Airport (MDW) to McGhee Tyson Airport (TYS)?
You can usually reschedule or cancel your MDW to TYS flight. However, if the booking was made more than 24 hours ago, additional fees may apply. Check your airline's policies in your itinerary to see what changes are possible and if any costs are involved. You'll also find further details on our Customer Service portal.

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*Available to One Key members.