$94 Cheap Flights from Chicago (MDW) to Knoxville (TYS)

View $94 flight on Sun, Dec 7, 2025Opens in a new window

Popular airlines from Chicago Midway Airport (MDW) to McGhee Tyson Airport (TYS)

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Cheap Flights from Chicago to Knoxville (MDW-TYS)

Prices were available within the past 7 days and start at $94 for one-way flights and $173 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frontier Airlines
Sun, Dec 7 - Thu, Dec 11
MDW
Chicago
TYS
Knoxville
$173 Roundtrip, found 2 days ago
$173
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Sun, Dec 7 from Chicago to Knoxville, returning Thu, Dec 11, priced at $173 found 2 days ago
Frontier Airlines
Sun, Dec 7 - Sun, Dec 14
MDW
Chicago
TYS
Knoxville
$186 Roundtrip, found 2 days ago
$186
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Sun, Dec 7 from Chicago to Knoxville, returning Sun, Dec 14, priced at $186 found 2 days ago
Delta
Tue, Nov 18 - Sun, Nov 23
MDW
Chicago
TYS
Knoxville
$209 Roundtrip, found 2 hours ago
$209
Roundtrip
found 2 hours ago
Select Delta flight, departing Tue, Nov 18 from Chicago to Knoxville, returning Sun, Nov 23, priced at $209 found 2 hours ago
Delta
Mon, Dec 8 - Thu, Dec 11
MDW
Chicago
TYS
Knoxville
$221 Roundtrip, found 1 day ago
$221
Roundtrip
found 1 day ago
Select Delta flight, departing Mon, Dec 8 from Chicago to Knoxville, returning Thu, Dec 11, priced at $221 found 1 day ago
Frontier Airlines
Sun, Dec 7 - Thu, Jan 15
MDW
Chicago
TYS
Knoxville
$223 Roundtrip, found 1 day ago
$223
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Sun, Dec 7 from Chicago to Knoxville, returning Thu, Jan 15, priced at $223 found 1 day ago
Delta
Tue, Mar 10 - Sat, Mar 14
MDW
Chicago
TYS
Knoxville
$234 Roundtrip, found 1 day ago
$234
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Mar 10 from Chicago to Knoxville, returning Sat, Mar 14, priced at $234 found 1 day ago
Delta
Tue, Nov 11 - Mon, Nov 17
MDW
Chicago
TYS
Knoxville
$239 Roundtrip, just found
$239
Roundtrip
just found
Select Delta flight, departing Tue, Nov 11 from Chicago to Knoxville, returning Mon, Nov 17, priced at $239 just found
Delta
Sat, Nov 22 - Mon, Nov 24
MDW
Chicago
TYS
Knoxville
$243 Roundtrip, just found
$243
Roundtrip
just found
Select Delta flight, departing Sat, Nov 22 from Chicago to Knoxville, returning Mon, Nov 24, priced at $243 just found
Delta
Sun, Nov 2 - Fri, Nov 14
MDW
Chicago
TYS
Knoxville
$244 Roundtrip, found 5 days ago
$244
Roundtrip
found 5 days ago
Select Delta flight, departing Sun, Nov 2 from Chicago to Knoxville, returning Fri, Nov 14, priced at $244 found 5 days ago
Southwest Airlines
Tue, May 12 - Mon, May 18
MDW
Chicago
TYS
Knoxville
$254 Roundtrip, found 1 hour ago
$254
Roundtrip
found 1 hour ago
Select Southwest Airlines flight, departing Tue, May 12 from Chicago to Knoxville, returning Mon, May 18, priced at $254 found 1 hour ago

Find the cheapest month to fly from Chicago (MDW) to Knoxville (TYS)

January is typically the cheapest month to fly

From $138 - $682 per traveler.

Alternative airports near Knoxville

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to McGhee Tyson TYS. Cheapest and Closest option available. Average driving time to city center is 22 minutes. Flights from $224
TYS
McGhee Tyson
CheapestClosest
Average driving time to city center22 min
Flights from $224

Frequently asked questions

How much does a flight from Midway Intl. Airport (MDW) to McGhee Tyson Airport (TYS) cost?
Snag a cheap one-way flight from $94 or cheap return flight from $173 from Midway Intl. Airport (MDW) to McGhee Tyson Airport (TYS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Midway Intl. Airport (MDW) to McGhee Tyson Airport (TYS)?
The cheapest month to fly from MDW to TYS is December, when demand is low. Off-peak months are often when you'll find lower airfares between these airports.
Which airlines fly direct from Midway Intl. Airport (MDW) to McGhee Tyson Airport (TYS)?
There are no direct routes from Chicago, IL (MDW-Midway Intl.) to McGhee Tyson Airport (TYS). However, you can find other airports that offer nonstop flights. Begin your journey at O'Hare Intl. Airport (ORD) and fly straight to Knoxville without layovers.
What is the cheapest airline that flies from Midway Intl. Airport (MDW) to McGhee Tyson Airport (TYS)?
Use the filters on Expedia to compare different airlines and find the most affordable carrier that'll fly you from MDW to TYS. Then, sort your results by "Price (lowest to highest)" to pick up a good deal.
How many flights per day from Midway Intl. Airport (MDW) to McGhee Tyson Airport (TYS)?
There are no daily direct flights available from Midway Intl. Airport (MDW) to McGhee Tyson Airport (TYS). But you can book flights with layovers. Filter your search on Expedia to include one or more stops, and you'll be soaring above the clouds in no time at all.
What day of the week has the most flights from MDW to TYS?
Usually you'll find the largest variety of flight choices on a Friday. Tuesdays are often the quietest.* However, this can vary based on the airline, season and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Midway Intl. Airport (MDW) to McGhee Tyson Airport (TYS)?
To arrive at McGhee Tyson Airport (TYS) on time, pick a flight that takes off from Midway Intl. Airport (MDW) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Midway Intl. Airport (MDW) to McGhee Tyson Airport (TYS) last-minute?
Last-minute bookings from MDW to TYS are typically more expensive. To secure the best rates, start looking for flights early. That said, if you can play around with your travel dates, it's possible to land a cheap ticket right before your journey.
Is it cheaper to book a MDW to TYS flight and hotel package?
Compared with arranging flights and hotels separately, booking a MDW to TYS flight and hotel package with Expedia could result in significant savings. What's more, having it all in one place takes the hassle out of planning your trip. Just pick your flights and choose from our wide range of hotels, then tailor your trip with extras like tours, activities and car rentals.
Can I cancel or change the date of my flight from Midway Intl. Airport (MDW) to McGhee Tyson Airport (TYS)?
You can usually reschedule or cancel your MDW to TYS flight. However, if the booking was made more than 24 hours ago, additional fees may apply. Check your airline's policies in your itinerary to see what changes are possible and if any costs are involved. You'll also find further details on our Customer Service portal.

Travel information

Origin airport
Midway Intl.
Destination airport
McGhee Tyson
Airlines serving
Delta, Frontier Airlines, Southwest Airlines
Roundtrip price
$173
Distance
459 mi
Average flight time
2 hours 24 mins

Book with confidence

Chicago to Knoxville Flights

The cheapest times to fly from Chicago to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Chicago to Knoxville are during the month of December. You can find some of the cheapest flights from Chicago to Knoxville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Chicago to Knoxville

Sunday is one of the best days to book for cheap flights from Chicago to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Chicago to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Chicago to Knoxville in 2025. You can also book with separate airlines for your outbound and return journeys, from $94 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Chicago to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Chicago to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Chicago to Knoxville Flights

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*Available to One Key members.