$144 Cheap Flights from Manchester (MHT) to St. Louis (STL)

View $144 flight on Wed, Feb 25, 2026Opens in a new window

Popular airlines from Manchester-Boston Regional Airport (MHT) to St. Louis Lambert Intl. Airport (STL)

Cheap Flights from Manchester to St. Louis (MHT-STL)

Prices were available within the past 7 days and start at $144 for one-way flights and $287 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Southwest Airlines
Wed, Jan 14 - Sun, Jan 18
MHT
Manchester
STL
St. Louis
$287 Roundtrip, found 1 day ago
$287
Roundtrip
found 1 day ago
Select Southwest Airlines flight, departing Wed, Jan 14 from Manchester to St. Louis, returning Sun, Jan 18, priced at $287 found 1 day ago
American Airlines
Wed, Jan 14 - Sun, Jan 18
MHT
Manchester
STL
St. Louis
$287 Roundtrip, found 1 day ago
$287
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Jan 14 from Manchester to St. Louis, returning Sun, Jan 18, priced at $287 found 1 day ago
Southwest Airlines
Wed, Jan 14 - Sun, Jan 18
MHT
Manchester
STL
St. Louis
$292 Roundtrip, found 1 day ago
$292
Roundtrip
found 1 day ago
Select Southwest Airlines flight, departing Wed, Jan 14 from Manchester to St. Louis, returning Sun, Jan 18, priced at $292 found 1 day ago
United
Wed, Jan 14 - Sun, Jan 18
MHT
Manchester
STL
St. Louis
$297 Roundtrip, found 1 day ago
$297
Roundtrip
found 1 day ago
Select United flight, departing Wed, Jan 14 from Manchester to St. Louis, returning Sun, Jan 18, priced at $297 found 1 day ago
United
Wed, Jan 14 - Sun, Jan 18
MHT
Manchester
STL
St. Louis
$299 Roundtrip, found 1 day ago
$299
Roundtrip
found 1 day ago
Select United flight, departing Wed, Jan 14 from Manchester to St. Louis, returning Sun, Jan 18, priced at $299 found 1 day ago
United
Mon, Dec 15 - Wed, Dec 17
MHT
Manchester
STL
St. Louis
$304 Roundtrip, found 3 days ago
$304
Roundtrip
found 3 days ago
Select United flight, departing Mon, Dec 15 from Manchester to St. Louis, returning Wed, Dec 17, priced at $304 found 3 days ago
Southwest Airlines
Thu, Dec 11 - Mon, Dec 15
MHT
Manchester
STL
St. Louis
$311 Roundtrip, found 4 hours ago
$311
Roundtrip
found 4 hours ago
Select Southwest Airlines flight, departing Thu, Dec 11 from Manchester to St. Louis, returning Mon, Dec 15, priced at $311 found 4 hours ago
Southwest Airlines
Thu, Dec 11 - Mon, Dec 15
MHT
Manchester
STL
St. Louis
$316 Roundtrip, found 4 hours ago
$316
Roundtrip
found 4 hours ago
Select Southwest Airlines flight, departing Thu, Dec 11 from Manchester to St. Louis, returning Mon, Dec 15, priced at $316 found 4 hours ago
United
Mon, Dec 15 - Wed, Dec 17
MHT
Manchester
STL
St. Louis
$321 Roundtrip, found 3 days ago
$321
Roundtrip
found 3 days ago
Select United flight, departing Mon, Dec 15 from Manchester to St. Louis, returning Wed, Dec 17, priced at $321 found 3 days ago
Southwest Airlines
Mon, Dec 22 - Thu, Dec 25
MHT
Manchester
STL
St. Louis
$327 Roundtrip, found 3 days ago
$327
Roundtrip
found 3 days ago
Select Southwest Airlines flight, departing Mon, Dec 22 from Manchester to St. Louis, returning Thu, Dec 25, priced at $327 found 3 days ago

Find the cheapest month to fly from Manchester (MHT) to St. Louis (STL)

August is typically the cheapest month to fly

From $178 - $746 per traveler.

Alternative airports near St. Louis

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Lambert-St. Louis Intl. STL. Cheapest option available. Average driving time to city center is 20 minutes. Flights from $467
STL
Lambert-St. Louis Intl.
Cheapest
Average driving time to city center20 min
Flights from $467

Frequently asked questions

How much does a flight from Manchester-Boston Regional Airport (MHT) to Lambert-St. Louis Intl. Airport (STL) cost?
Secure a cheap one-way flight from $144 or cheap return flight from $287 from Manchester-Boston Regional Airport (MHT) to Lambert-St. Louis Intl. Airport (STL) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Manchester-Boston Regional Airport (MHT) to Lambert-St. Louis Intl. Airport (STL)?
Traveling in January can help you save, as it's the cheapest month for flights between MHT and STL. You'll typically find the lowest fares during off-peak months.
Which airlines fly direct from Manchester-Boston Regional Airport (MHT) to Lambert-St. Louis Intl. Airport (STL)?
You can't fly directly from Manchester, NH (MHT-Manchester-Boston Regional) to Lambert-St. Louis Intl. Airport (STL). However, there are other airports offering nonstop flights. Begin your journey at Logan Intl. Airport (BOS) and head straight to St. Louis without any detours.
What is the cheapest airline that flies from Manchester-Boston Regional Airport (MHT) to Lambert-St. Louis Intl. Airport (STL)?
Expedia's filter tool lets you easily compare airlines, flight times and baggage options all in one place. Choose your preferences, then sort by "Price (lowest to highest)" to find out which carrier offers the cheapest MHT to STL flight.
How many flights per day from Manchester-Boston Regional Airport (MHT) to Lambert-St. Louis Intl. Airport (STL)?
Nonstop flights from Manchester-Boston Regional Airport (MHT) to Lambert-St. Louis Intl. Airport (STL) aren't available daily, so you'll have to take a flight with a layover. Explore your options with our filter tool. Enter your travel details and choose either "1 Stop" or "2+ Stops."
What day of the week has the most flights from MHT to STL?
Generally you'll have the most choice when it comes to flights on a Friday. Tuesdays are often the quietest.* But this can vary depending on the time of year, airline and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Manchester-Boston Regional Airport (MHT) to Lambert-St. Louis Intl. Airport (STL)?
To avoid possible delays on the Manchester-Boston Regional Airport (MHT) to Lambert-St. Louis Intl. Airport (STL) route, travel before 3 PM. Later departures have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Manchester-Boston Regional Airport (MHT) to Lambert-St. Louis Intl. Airport (STL) last-minute?
Holding off until just before your departure to book your flight from MHT to STL generally means paying more. While you may find some last-minute deals, they're not always guaranteed. Be flexible with your travel plans for a better chance of scoring a bargain.
Is it cheaper to book a MHT to STL flight and hotel package?
Booking a MHT to STL flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your trip all in one place. Select from our impressive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Manchester-Boston Regional Airport (MHT) to Lambert-St. Louis Intl. Airport (STL)?
Generally, it's possible to cancel or reschedule your MHT to STL flight. However, for bookings made more than 24 hours ago, additional charges may apply. Check your airline's policies in your itinerary to see what changes are allowed and whether any costs are involved. You'll also find more information on our Customer Service portal.

Travel information

Origin airport
Manchester-Boston Regional
Destination airport
Lambert-St. Louis Intl.
Airlines serving
American Airlines, Southwest Airlines, United
Roundtrip price
$286
Distance
1028 mi

Book with confidence

Manchester to St. Louis Flights

The cheapest times to fly from Manchester to St. Louis

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Manchester to St. Louis are during the month of January. You can find some of the cheapest flights from Manchester to St. Louis with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Manchester to St. Louis

Sunday is one of the best days to book for cheap flights from Manchester to St. Louis: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Manchester to St. Louis

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Manchester to St. Louis in 2025. You can also book with separate airlines for your outbound and return journeys, from $144 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Manchester to St. Louis flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Manchester to St. Louis airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Manchester to St. Louis Flights

Explore a world of travel with Expedia

*Available to One Key members.