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$274 Cheap Flights from Mobile (MOB) to St. Louis (STL)

View $274 flight on Fri, Oct 23, 2026Opens in a new window

Popular airlines from Mobile Regional Airport (MOB) to St. Louis Lambert Intl. Airport (STL)

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Cheap Flights from Mobile to St. Louis (MOB-STL)

Prices were available within the past 7 days and start at $274 for one-way flights and $319 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Fri, Oct 23 - Sun, Oct 25
MOB
Mobile
STL
St. Louis
$319 Roundtrip, found 1 hour ago
$319
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Fri, Oct 23 from Mobile to St. Louis, returning Sun, Oct 25, priced at $319 found 1 hour ago
United
Wed, Oct 21 - Wed, Oct 28
MOB
Mobile
STL
St. Louis
$324 Roundtrip, found 10 hours ago
$324
Roundtrip
found 10 hours ago
Select United flight, departing Wed, Oct 21 from Mobile to St. Louis, returning Wed, Oct 28, priced at $324 found 10 hours ago
United
Fri, Oct 2 - Mon, Oct 5
MOB
Mobile
STL
St. Louis
$327 Roundtrip, found 4 days ago
$327
Roundtrip
found 4 days ago
Select United flight, departing Fri, Oct 2 from Mobile to St. Louis, returning Mon, Oct 5, priced at $327 found 4 days ago
Delta
Thu, Sep 24 - Wed, Sep 30
MOB
Mobile
STL
St. Louis
$333 Roundtrip, found 1 day ago
$333
Roundtrip
found 1 day ago
Select Delta flight, departing Thu, Sep 24 from Mobile to St. Louis, returning Wed, Sep 30, priced at $333 found 1 day ago
American Airlines
Thu, Sep 24 - Sun, Sep 27
MOB
Mobile
STL
St. Louis
$334 Roundtrip, found 6 hours ago
$334
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Thu, Sep 24 from Mobile to St. Louis, returning Sun, Sep 27, priced at $334 found 6 hours ago
United
Wed, Oct 21 - Wed, Oct 28
MOB
Mobile
STL
St. Louis
$337 Roundtrip, found 10 hours ago
$337
Roundtrip
found 10 hours ago
Select United flight, departing Wed, Oct 21 from Mobile to St. Louis, returning Wed, Oct 28, priced at $337 found 10 hours ago
United
Wed, Oct 21 - Wed, Oct 28
MOB
Mobile
STL
St. Louis
$342 Roundtrip, found 10 hours ago
$342
Roundtrip
found 10 hours ago
Select United flight, departing Wed, Oct 21 from Mobile to St. Louis, returning Wed, Oct 28, priced at $342 found 10 hours ago
United
Thu, Nov 12 - Sun, Nov 15
MOB
Mobile
STL
St. Louis
$346 Roundtrip, found 10 hours ago
$346
Roundtrip
found 10 hours ago
Select United flight, departing Thu, Nov 12 from Mobile to St. Louis, returning Sun, Nov 15, priced at $346 found 10 hours ago
Delta
Fri, Oct 23 - Sun, Oct 25
MOB
Mobile
STL
St. Louis
$353 Roundtrip, found 1 hour ago
$353
Roundtrip
found 1 hour ago
Select Delta flight, departing Fri, Oct 23 from Mobile to St. Louis, returning Sun, Oct 25, priced at $353 found 1 hour ago
United
Wed, Sep 23 - Sat, Sep 26
MOB
Mobile
STL
St. Louis
$363 Roundtrip, found 17 hours ago
$363
Roundtrip
found 17 hours ago
Select United flight, departing Wed, Sep 23 from Mobile to St. Louis, returning Sat, Sep 26, priced at $363 found 17 hours ago

Find the cheapest month to fly from Mobile (MOB) to St. Louis (STL)

February is typically the cheapest month to fly

From $248 - $406 per traveler.

What you need to know for your flight from Mobile Regional to Lambert-St. Louis Intl.

Mobile (MOB) to St. Louis (STL) at a glance

Travel to St. Louis (STL) from Mobile (MOB) with a selection of airlines offering convenient short-haul flights. Explore various options from full-service carriers to find the itinerary that aligns with your budget, schedule, and travel preferences while you discover the renowned attractions and neighborhoods of St. Louis. Get all the essential information for flights departing from Mobile Regional Airport (MOB) to Lambert-St. Louis International Airport (STL).

  • Fastest flight duration: around 3h 45m in-flight, plus roughly 1h 30m layover with one stop
  • Route distance: roughly 600 miles (970 km)
  • Flights per week: around 8 departures on average
  • Typical fares (one-way): economy tickets often range from $120–$485, depending on seasonality and how far ahead you book

Flights from Mobile Regional Airport (MOB) to Lambert-St. Louis International Airport (STL)

Based on the latest traveler reservations, here are the top airlines preferred for one-stop flights from Mobile to St. Louis. Many travelers choose routes with layovers at Hartsfield-Jackson Atlanta International Airport (ATL, approximately 1 hour 30 minutes), Dallas-Fort Worth International Airport (DFW, also around 1 hour 30 minutes), and George Bush Intercontinental Airport (IAH, roughly 1 hour 15 minutes). This allows you to easily compare prices, total travel times, and cabin classes to create the best travel itinerary for your needs.

  • Delta: As a comprehensive airline providing one-stop service, Delta represents about 47% of the departures on this route. One-way ticket prices generally fall between $120 and $505. The flight duration is approximately 3 hours and 45 minutes, with an overall travel time of around 5 hours and 15 minutes, including layover.
  • American Airlines: This full-service airline, also offering one-stop options, makes up roughly 29% of the departures for this route. Passengers can expect one-way fares in the range of $140 to $465. The in-flight time is similar at 3 hours and 45 minutes, bringing the total journey to about 5 hours and 15 minutes, factoring in the layover.
  • United: Another full-service carrier providing one-stop service, United accounts for about 23% of the departures on this route. One-way prices typically range from $135 to $450. The flight lasts around 3 hours and 45 minutes, with the complete travel time being approximately 5 hours and 15 minutes, including any layover.

Best time to fly from Mobile (MOB) to St. Louis (STL)

The most popular months for travelers flying from Mobile to St. Louis are February, April, and June, when peak temperatures in St. Louis reach up to 76.1°F in June. If you prefer quieter travel, consider August, the least busy time to visit with temperatures around 77°F and typically the lowest average one-way fare (around $188). Flight availability peaks in November, with approximately 11 flights per week, making it easier to find convenient departure times.

  • Cheapest time to fly: August usually offers good deals with average one-way fare around $188, roughly 33% cheaper than the yearly average.
  • Most flight options: November has the highest number of flights from Mobile to St. Louis, with approximately 11 flights per week, giving you more flexibility in scheduling your trip.
calendar iconMonthtemperature iconTemperaturecrowd level iconDemandflights iconWeekly Flightsprice iconAverage one-way Fare
January31.6°F (-0.2°C)Average7$327
February34.9°F (1.6°C)High8$280
March46.4°F (8.0°C)Average7$352
April56.1°F (13.4°C)High8$323
May66.6°F (19.2°C)Average8$236
June76.1°F (24.5°C)High8$255
July78.6°F (25.9°C)Average8$225
August77.0°F (25.0°C)Low7$188
September70.9°F (21.6°C)Average8$278
October58.6°F (14.8°C)Average8$341
November46.2°F (7.9°C)Low11$261
December37.8°F (3.2°C)Low7$322

*Average one-way fare is based on Expedia flight booking data from January 2025 to April 2026 for the specified route and travel class and may change depending on availability, dates, and demand.

Alternative route from Mobile (MOB) to St. Louis (STL)

  • Gulfport to St. Louis (GPT-STL): Gulfport - Biloxi International Airport (GPT) is located approximately 53 miles from Mobile Regional Airport (MOB). One-way economy tickets for this route generally fall between $120 and $425, influenced by the time of year and how early you make your reservation. Travelers will typically find one-stop flights, with common layover points being Hartsfield-Jackson Atlanta International Airport (ATL) and Dallas-Fort Worth International Airport (DFW). Major airlines servicing this route include Delta and American Airlines. Additionally, options for business and first-class service are available.

How to find the best prices for flights from Mobile (MOB) to St. Louis (STL)

Getting some of the best deals on flights from Mobile to St. Louis is all about timing and flexibility. Here are some key tips to help you save:

  1. Best times to book and fly: cheaper fares are usually found when booking 2-8 weeks in advance, though most travelers tend to book within 2 weeks. Evening departures from 6 PM to 12 AM often offer lower prices, while morning flights between 5 AM and 12 PM are the most popular. Additionally, flying on Thursday generally results in cheaper rates, although Friday remains the busiest travel day.
  2. Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
  3. Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.*
  4. Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
  5. Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
  6. Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.

*Members only. Savings vary and are not available on all bundles. Select hotels.

Arriving at Lambert-St. Louis International Airport from Mobile Regional Airport

St. Louis welcomes travelers from Mobile with a range of transport options based on price, convenience, and proximity. Here's how to reach St. Louis efficiently:

  • Hotel transfer: Transfers offer a convenient way to reach your hotel in St. Louis, with private rides that can be arranged in advance.
  • Car rental: Renting a car from Lambert-St. Louis International Airport is a great option if you plan to explore and sightsee beyond the city. Browse cheap car rentals at Lambert-St. Louis International Airport on Expedia.
  • Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.
  • Public transportation: From Lambert-St. Louis International Airport, Lambert Main Terminal Station, a metro station, is conveniently located just 0.1 miles away on foot, providing easy access to public transportation.

Frequently asked questions

How much does a flight from Mobile, AL (MOB-Mobile Regional) to St. Louis, MO (STL-Lambert-St. Louis Intl.) cost?
You can find cheap one-way flights from $274 and cheap return flights from $319 Mobile, AL (MOB-Mobile Regional) to St. Louis, MO (STL-Lambert-St. Louis Intl.) with Expedia. One-way flights typically cost between $305 and $784, and return flights often range between $368 and $1239. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Mobile, AL (MOB-Mobile Regional) to St. Louis, MO (STL-Lambert-St. Louis Intl.) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Mobile, AL (MOB-Mobile Regional) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
May is the cheapest month to fly from Mobile to St. Louis, with average round-trip fares around $337. This is about 12% lower than the average price throughout the year, as travel demand tends to be lower in spring. Other budget-friendly months include September and October.*Averages based on flights available on Expedia in the last year.
Which airlines fly direct from Mobile, AL (MOB-Mobile Regional) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
Enter MOB to STL and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Mobile, AL (MOB-Mobile Regional) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
American Airlines is one of the cheapest airlines offering connecting flights from Mobile Regional (MOB) to Lambert-St. Louis Intl. (STL) with a layover in Charlotte-Douglas Intl. (CLT) starting from around $650. Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Mobile, AL (MOB-Mobile Regional) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
To find a cheap flight from Mobile, AL (MOB-Mobile Regional) to St. Louis, MO (STL-Lambert-St. Louis Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Mobile, AL (MOB-Mobile Regional) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
For flights from Mobile, AL (MOB) to St. Louis, MO (STL), the best months to travel are May and October. May offers return flights at around $337, making it a budget-friendly choice, while October also provides good value and pleasant weather. This insight is based on booking data from the past year, ensuring you have a solid plan for your journey.*Prices based on flights available on Expedia in the last year.
What is the earliest flight from Mobile, AL (MOB-Mobile Regional) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
The earliest flight from Mobile Regional (MOB) to Lambert-St. Louis International (STL) typically departs at around 5:05 AM, operated by American Airlines. This seasonal service can help you start your day early and maximize your time in St. Louis. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Mobile, AL (MOB-Mobile Regional) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
The most popular departure times for flights from Mobile, AL (MOB) to St. Louis, MO (STL) are in the late morning, from 9am to noon. About 34% of passengers prefer this time window. Many major carriers, including American Airlines and United Airlines, offer flights during this window. This timing works well because it allows you to travel after breakfast and arrive in St. Louis with plenty of time to explore.
How long does it take to fly from Mobile, AL (MOB-Mobile Regional) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
Flying from MOB to STL with a connection usually takes about 6 hours 50 minutes, traveling roughly 570 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Mobile, AL (MOB-Mobile Regional) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
You can fly first class between MOB and STL. First class cabins are available on:

  • American Airlines
  • Delta Air Lines
  • United Airlines

How do I earn miles on a Mobile, AL (MOB-Mobile Regional) to St. Louis, MO (STL-Lambert-St. Louis Intl.) flight with Expedia?
It's easy to earn miles on a Mobile, AL (MOB-Mobile Regional) to St. Louis, MO (STL-Lambert-St. Louis Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for St. Louis from Mobile Regional (MOB)?
From Mobile Regional (MOB), you can fly into Lambert-St. Louis Intl. (STL) to reach St. Louis. Some flights may connect through major hubs like George Bush Intercontinental (IAH), Charlotte-Douglas Intl. (CLT), Washington Dulles Intl. (IAD) before reaching St. Louis. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Mobile, AL (MOB-Mobile Regional) to St. Louis, MO (STL-Lambert-St. Louis Intl.) at the last minute?
Typically, booking a last minute flight from Mobile, AL (MOB-Mobile Regional) to St. Louis, MO (STL-Lambert-St. Louis Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Mobile, AL (MOB-Mobile Regional) to St. Louis, MO (STL-Lambert-St. Louis Intl.) flight and hotel package?
Securing a Mobile, AL (MOB-Mobile Regional) to St. Louis, MO (STL-Lambert-St. Louis Intl.) St Louis Vacation Packages is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Mobile, AL (MOB-Mobile Regional) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
If you booked your Mobile, AL (MOB-Mobile Regional) to St. Louis, MO (STL-Lambert-St. Louis Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Mobile Regional
Destination airport
Lambert-St. Louis Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
$318
Distance
569 mi

Book with confidence

Mobile to St. Louis Flights

The cheapest times to fly from Mobile to St. Louis

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Mobile to St. Louis are during the month of October. You can find some of the cheapest flights from Mobile to St. Louis with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Mobile to St. Louis

Sunday is one of the best days to book for cheap flights from Mobile to St. Louis: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Mobile to St. Louis

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Mobile to St. Louis in 2026. You can also book with separate airlines for your outbound and return journeys, from $274 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Mobile to St. Louis flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Mobile to St. Louis airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Mobile to St. Louis Flights

*Flight schedules are subject to change.

*Available to One Key members.

 

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