$205 Cheap Flights from Myrtle Beach (MYR) to Panama City (PTY)

View $205 flight on Thu, Dec 4, 2025Opens in a new window

Popular airlines from Myrtle Beach Intl. Airport (MYR) to Tocumen Intl. Airport (PTY)

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Cheap Flights from Myrtle Beach to Panama City (MYR-PTY)

Prices were available within the past 7 days and start at $205 for one-way flights and $440 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Thu, Dec 4 - Wed, Dec 10
MYR
Myrtle Beach
PTY
Panama City
$440 Roundtrip, found 1 hour ago
$440
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Thu, Dec 4 from Myrtle Beach to Panama City, returning Wed, Dec 10, priced at $440 found 1 hour ago
Delta
Sun, Feb 1 - Wed, Feb 11
MYR
Myrtle Beach
PTY
Panama City
$443 Roundtrip, found 3 days ago
$443
Roundtrip
found 3 days ago
Select Delta flight, departing Sun, Feb 1 from Myrtle Beach to Panama City, returning Wed, Feb 11, priced at $443 found 3 days ago
Delta
Sun, Mar 8 - Wed, Mar 11
MYR
Myrtle Beach
PTY
Panama City
$450 Roundtrip, found 3 days ago
$450
Roundtrip
found 3 days ago
Select Delta flight, departing Sun, Mar 8 from Myrtle Beach to Panama City, returning Wed, Mar 11, priced at $450 found 3 days ago
Delta
Fri, Dec 5 - Tue, Dec 16
MYR
Myrtle Beach
PTY
Panama City
$456 Roundtrip, found 3 days ago
$456
Roundtrip
found 3 days ago
Select Delta flight, departing Fri, Dec 5 from Myrtle Beach to Panama City, returning Tue, Dec 16, priced at $456 found 3 days ago
Delta
Sun, Dec 7 - Sun, Dec 21
MYR
Myrtle Beach
PTY
Panama City
$463 Roundtrip, found 3 days ago
$463
Roundtrip
found 3 days ago
Select Delta flight, departing Sun, Dec 7 from Myrtle Beach to Panama City, returning Sun, Dec 21, priced at $463 found 3 days ago
Delta
Mon, Jan 12 - Fri, Jan 23
MYR
Myrtle Beach
PTY
Panama City
$470 Roundtrip, found 12 hours ago
$470
Roundtrip
found 12 hours ago
Select Delta flight, departing Mon, Jan 12 from Myrtle Beach to Panama City, returning Fri, Jan 23, priced at $470 found 12 hours ago
American Airlines
Thu, Jan 8 - Thu, Jan 15
MYR
Myrtle Beach
PTY
Panama City
$472 Roundtrip, found 5 days ago
$472
Roundtrip
found 5 days ago
Select American Airlines flight, departing Thu, Jan 8 from Myrtle Beach to Panama City, returning Thu, Jan 15, priced at $472 found 5 days ago
United
Tue, Mar 3 - Mon, Mar 9
MYR
Myrtle Beach
PTY
Panama City
$475 Roundtrip, found 3 days ago
$475
Roundtrip
found 3 days ago
Select United flight, departing Tue, Mar 3 from Myrtle Beach to Panama City, returning Mon, Mar 9, priced at $475 found 3 days ago
American Airlines
Thu, Dec 4 - Wed, Dec 10
MYR
Myrtle Beach
PTY
Panama City
$476 Roundtrip, found 1 hour ago
$476
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Thu, Dec 4 from Myrtle Beach to Panama City, returning Wed, Dec 10, priced at $476 found 1 hour ago
American Airlines
Thu, Jan 8 - Thu, Jan 15
MYR
Myrtle Beach
PTY
Panama City
$478 Roundtrip, found 5 days ago
$478
Roundtrip
found 5 days ago
Select American Airlines flight, departing Thu, Jan 8 from Myrtle Beach to Panama City, returning Thu, Jan 15, priced at $478 found 5 days ago

Alternative airports near Panama City

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Tocumen Intl. PTY. Cheapest option available. Average driving time to city center is 16 minutes. Flights from $503
PTY
Tocumen Intl.
Cheapest
Average driving time to city center16 min
Flights from $503

Frequently asked questions

How much does a flight from Myrtle Beach Intl. Airport (MYR) to Tocumen Intl. Airport (PTY) cost?
Secure a cheap one-way flight from $205 or cheap return flight from $440 from Myrtle Beach Intl. Airport (MYR) to Tocumen Intl. Airport (PTY) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Myrtle Beach Intl. Airport (MYR) to Tocumen Intl. Airport (PTY)?
The cheapest month to fly from MYR to PTY is December, when demand is low. Off-peak months are usually when airlines offer lower prices between these airports.
What is the cheapest airline that flies from Myrtle Beach Intl. Airport (MYR) to Tocumen Intl. Airport (PTY)?
Use the filters on Expedia to compare different airlines and find the cheapest carrier that'll fly you from MYR to PTY. Then, sort your results by "Price (lowest to highest)" to snag a great deal.
How many flights per day from Myrtle Beach Intl. Airport (MYR) to Tocumen Intl. Airport (PTY)?
You'll need to book a flight with a layover if you're traveling from Myrtle Beach Intl. Airport (MYR) to Tocumen Intl. Airport (PTY). Direct flights don't operate daily on this route. However, simply filter your search to include one or more stops to find the best option for your trip.
What day of the week has the most flights from MYR to PTY?
Friday is generally the busiest day for flights, while Tuesday tends to be the quietest.* Keep in mind that flight schedules can change depending on various factors, such as the carrier and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Myrtle Beach Intl. Airport (MYR) to Tocumen Intl. Airport (PTY)?
Choose a flight from Myrtle Beach Intl. Airport (MYR) to Tocumen Intl. Airport (PTY) that leaves before 3 PM to reduce the risk of cancellations. Later departures have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Myrtle Beach Intl. Airport (MYR) to Tocumen Intl. Airport (PTY) last-minute?
Booking your flight from MYR to PTY right before your trip is usually more expensive. But if you're flexible with your departure times and dates, you could land a cheap last-minute fare.
Is it cheaper to book a MYR to PTY flight and hotel package?
Booking a MYR to PTY flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your travels in one place. Choose from our wide range of hotels and then add flights, activities and car rentals to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Myrtle Beach Intl. Airport (MYR) to Tocumen Intl. Airport (PTY)?
Typically, you can modify or cancel your MYR to PTY flight. However, there may be additional fees, especially if you made your booking over 24 hours ago. Check your itinerary for the airline's fees and guidelines on flight changes, or if you want further details, visit our Customer Service portal.

Travel information

Origin airport
Myrtle Beach Intl.
Destination airport
Tocumen Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
$440
Distance
1700 mi

Book with confidence

Myrtle Beach to Panama City Flights

The cheapest times to fly from Myrtle Beach to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Myrtle Beach to Panama City are during the month of December. You can find some of the cheapest flights from Myrtle Beach to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Myrtle Beach to Panama City

Sunday is one of the best days to book for cheap flights from Myrtle Beach to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Myrtle Beach to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Myrtle Beach to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $205 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Myrtle Beach to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Myrtle Beach to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Myrtle Beach to Panama City Flights

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*Available to One Key members.