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$139 Cheap Flights from Syracuse (SYR) to St. Louis (STL)

View $139 flight on Mon, Oct 19, 2026Opens in a new window

Popular airlines from Hancock Intl. Airport (SYR) to St. Louis Lambert Intl. Airport (STL)

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Cheap Flights from Syracuse to St. Louis (SYR-STL)

Prices were available within the past 7 days and start at $139 for one-way flights and $301 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Nov 4 - Tue, Nov 10
SYR
Syracuse
STL
St. Louis
$301 Roundtrip, found 1 day ago
$301
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Nov 4 from Syracuse to St. Louis, returning Tue, Nov 10, priced at $301 found 1 day ago
American Airlines
Wed, Nov 4 - Mon, Nov 9
SYR
Syracuse
STL
St. Louis
$310 Roundtrip, found 1 day ago
$310
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Nov 4 from Syracuse to St. Louis, returning Mon, Nov 9, priced at $310 found 1 day ago
United
Tue, Oct 20 - Thu, Oct 29
SYR
Syracuse
STL
St. Louis
$315 Roundtrip, found 2 days ago
$315
Roundtrip
found 2 days ago
Select United flight, departing Tue, Oct 20 from Syracuse to St. Louis, returning Thu, Oct 29, priced at $315 found 2 days ago
American Airlines
Tue, Dec 1 - Thu, Dec 31
SYR
Syracuse
STL
St. Louis
$320 Roundtrip, found 1 day ago
$320
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Dec 1 from Syracuse to St. Louis, returning Thu, Dec 31, priced at $320 found 1 day ago
Delta
Tue, Oct 20 - Tue, Oct 27
SYR
Syracuse
STL
St. Louis
$321 Roundtrip, just found
$321
Roundtrip
just found
Select Delta flight, departing Tue, Oct 20 from Syracuse to St. Louis, returning Tue, Oct 27, priced at $321 just found
United
Tue, Oct 20 - Tue, Oct 27
SYR
Syracuse
STL
St. Louis
$326 Roundtrip, just found
$326
Roundtrip
just found
Select United flight, departing Tue, Oct 20 from Syracuse to St. Louis, returning Tue, Oct 27, priced at $326 just found
United
Sat, Oct 17 - Mon, Oct 19
SYR
Syracuse
STL
St. Louis
$330 Roundtrip, found 1 day ago
$330
Roundtrip
found 1 day ago
Select United flight, departing Sat, Oct 17 from Syracuse to St. Louis, returning Mon, Oct 19, priced at $330 found 1 day ago
United
Fri, Nov 27 - Fri, Dec 4
SYR
Syracuse
STL
St. Louis
$334 Roundtrip, found 6 days ago
$334
Roundtrip
found 6 days ago
Select United flight, departing Fri, Nov 27 from Syracuse to St. Louis, returning Fri, Dec 4, priced at $334 found 6 days ago
United
Wed, Oct 21 - Mon, Oct 26
SYR
Syracuse
STL
St. Louis
$335 Roundtrip, found 6 days ago
$335
Roundtrip
found 6 days ago
Select United flight, departing Wed, Oct 21 from Syracuse to St. Louis, returning Mon, Oct 26, priced at $335 found 6 days ago
Frontier Airlines
Mon, Nov 16 - Fri, Nov 20
SYR
Syracuse
STL
St. Louis
$478 Roundtrip, found 3 days ago
$478
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Mon, Nov 16 from Syracuse to St. Louis, returning Fri, Nov 20, priced at $478 found 3 days ago

Alternative airports near St. Louis

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Lambert-St. Louis Intl. STL. Cheapest option available. Average driving time to city center is 20 minutes. Flights from $642
STL
Lambert-St. Louis Intl.
Cheapest
Average driving time to city center20 min
Flights from $642

What you need to know for your flight from Hancock Intl. to Lambert-St. Louis Intl.

Syracuse (SYR) to St. Louis (STL) at a glance

Travel from Syracuse (SYR) to St. Louis (STL) with a range of airlines serving this domestic short-haul route. Whether you prefer full-service airlines or budget-friendly options, you can easily compare flights to find the itinerary that aligns with your budget, schedule, and travel plans as you discover the highlights of St. Louis. Get all the essential information for flights departing from Hancock International Airport (SYR) to Lambert-St. Louis International Airport (STL).

  • Fastest flight duration: around 3h 45m in-flight, plus roughly 1h 15m layover with one stop
  • Route distance: roughly 800 miles (1,290 km)
  • Flights per week: around 12 departures on average
  • Typical fares (one-way): economy tickets often range from $125–$400, depending on seasonality and how far ahead you book

Flights from Hancock International Airport (SYR) to Lambert-St. Louis International Airport (STL)

Based on the latest traveler bookings, here are the most popular airlines flying from Syracuse to St. Louis, particularly favored for their one-stop service. Common layover spots include Detroit Metropolitan Wayne County Airport (DTW) with about a 1h 15m layover, O'Hare International Airport (ORD) also with a 1h 15m layover, and Hartsfield-Jackson Atlanta International Airport (ATL), which typically has a 1h 15m layover. These options allow you to tailor your journey by balancing price, total travel time, and cabin class for the ideal itinerary.

  • Delta: This major airline provides a full-service experience with one-stop options, featuring one-way fares generally between $125 and $375. Delta represents nearly 48% of departures on this route, with a flight duration of 3 hours and 45 minutes, leading to an overall travel time of about 5 hours, including layover.
  • American Airlines: Another full-service provider, American Airlines offers one-stop flights with one-way ticket prices typically ranging from $125 to $430. It accounts for around 38% of departures on this route, with an in-flight duration of 3 hours and 45 minutes and a total travel time of approximately 5 hours, inclusive of layover.
  • United: United Airlines operates as a full-service carrier with one-stop services, where one-way fares usually fall between $135 and $420. It makes up about 13% of departures on this route, featuring a flight time of 3 hours and 45 minutes, and a total journey time of close to 5 hours, factoring in layover.

Travelers flying from Syracuse to St. Louis can opt to enhance their experience with upgraded seating. Delta provides both first class and premium economy options, while American Airlines exclusively features first class service.

Best time to fly from Syracuse (SYR) to St. Louis (STL)

The most popular months for travelers flying from Syracuse to St. Louis are March, April, and May, when peak temperatures in St. Louis reach up to 66.6°F in May. If you prefer quieter travel, consider December, the least busy and relatively cheaper time to visit with fewer crowds and temperatures around 37.8°F. For better deals, July usually offers the lowest average one-way fare around $184. Flight availability peaks in May, with approximately 16 flights per week, making it easier to find convenient departure times. January has the fewest flights, with approximately 8 flights per week.

  • Cheapest time to fly: July usually offers good deals with average one-way fare around $184, roughly 18% cheaper than the yearly average.
  • More budget-friendly months to fly: August and May typically offer average one-way fares of around $195.
  • Most flight options: May has the highest number of flights from Syracuse to St. Louis, with approximately 16 flights per week, giving you more flexibility in scheduling your trip.
calendar iconMonthtemperature iconTemperaturecrowd level iconDemandflights iconWeekly Flightsprice iconAverage one-way Fare
January31.6°F (-0.2°C)Moderately Low8$229
February34.9°F (1.6°C)Average10$266
March46.4°F (8.0°C)Moderately High10$242
April56.1°F (13.4°C)Moderately High12$254
May66.6°F (19.2°C)Moderately High16$197
June76.1°F (24.5°C)Average11$231
July78.6°F (25.9°C)Average14$184
August77.0°F (25.0°C)Average13$193
September70.9°F (21.6°C)Average14$213
October58.6°F (14.8°C)Moderately Low11$235
November46.2°F (7.9°C)Average12$239
December37.8°F (3.2°C)Moderately Low10$220

*Average one-way fare is based on Expedia flight booking data from January 2025 to April 2026 for the specified route and travel class and may change depending on availability, dates, and demand.

Alternative routes from Syracuse (SYR) to St. Louis (STL)

  • Syracuse to St. Louis (SYR-CPS): The St. Louis Downtown Airport (CPS) lies approximately 16 miles from Lambert-St. Louis International Airport (STL).
  • Rome to St. Louis (RME-STL): Griffiss International Airport (RME) is located about 36 miles from Hancock International Airport (SYR).

How to find the best prices for flights from Syracuse (SYR) to St. Louis (STL)

Getting some of the best deals on flights from Syracuse to St. Louis is all about timing and flexibility. Here are some key tips to help you save:

  1. Best times to book and fly: cheaper fares are usually found when booking 2 to 8 weeks in advance, which aligns with when most travelers make their reservations. Afternoon departures from 12 PM to 6 PM often offer lower prices, even though morning flights from 5 AM to 12 PM are the most popular. Additionally, flying on Tuesday generally provides cheaper rates, while Friday remains the busiest travel day.
  2. Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
  3. Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.*
  4. Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
  5. Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
  6. Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.

*Members only. Savings vary and are not available on all bundles. Select hotels.

Arriving at Lambert-St. Louis International Airport from Hancock International Airport

St. Louis welcomes travelers from Syracuse with a range of transport options based on price, convenience, and proximity. For departures, Hancock International Airport is roughly a 10-minute drive (covering about 8 miles) from central Syracuse. Here's how to reach St. Louis efficiently:

  • Hotel transfer: Transfers offer a convenient way to reach your hotel in St. Louis, with private rides that can be arranged in advance.
  • Car rental: Renting a car from Lambert-St. Louis International Airport is a great option if you plan to explore and sightsee beyond the city. Browse cheap car rentals at Lambert-St. Louis International Airport on Expedia.
  • Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.
  • Public transportation: From Lambert-St. Louis International Airport, Lambert Main Terminal Station, a metro station, is located about 0.1 miles away on foot, providing easy access to public transportation for travelers.

Frequently asked questions

How much does a flight from Syracuse, NY (SYR-Hancock Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.) cost?
You can find cheap one-way flights from $139 and cheap return flights from $301 Syracuse, NY (SYR-Hancock Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.) with Expedia. One-way flights usually range from $238 to $675, and return flights typically cost between $351 and $1211. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Syracuse, NY (SYR-Hancock Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Syracuse, NY (SYR-Hancock Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
September is the cheapest month to fly from Syracuse (SYR) to St. Louis (STL), with average return fares around $339. This is about 18% lower than the average price, as early fall often sees a dip in travel demand. Other budget-friendly months to consider are January and August.*Averages based on flights available on Expedia in the last year.
Which airlines fly direct from Syracuse, NY (SYR-Hancock Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
Enter SYR to STL and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Syracuse, NY (SYR-Hancock Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
American Airlines is one of the cheapest airlines offering connecting flights from Syracuse, NY (SYR) to St. Louis, MO (STL) with a layover in Ronald Reagan Washington National (DCA), starting from around $248 for a round-trip ticket. Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Syracuse, NY (SYR-Hancock Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
To find a cheap flight from Syracuse, NY (SYR-Hancock Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Syracuse, NY (SYR-Hancock Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
The best time to fly from Syracuse, NY (SYR) to St. Louis, MO (STL) is typically in September or January. September offers a great balance of moderate prices at around $339 for a return flight and a good travel experience, while January is also affordable, making it a smart choice for budget-conscious travelers. These months are ideal as they fall outside of peak travel seasons, allowing you to enjoy lower fares and more flight options.*Prices based on flights available on Expedia in the last year.
What is the earliest flight from Syracuse, NY (SYR-Hancock Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
The earliest flight from Hancock International Airport (SYR) to Lambert-St. Louis International Airport (STL) typically departs at around 5:00 AM local time, operated by American Airlines. This seasonal service is available in March, allowing you to maximize your time in St. Louis. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Syracuse, NY (SYR-Hancock Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
The most popular departure times for flights from Syracuse, NY (SYR-Hancock Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.) are in the early morning, from 6am to 9am. About 32% of passengers prefer this time window. Airlines like American Airlines, Delta, and United operate flights during this period, making it a convenient option for early risers.
How long does it take to fly from Syracuse, NY (SYR-Hancock Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
Flying from SYR to STL with a connection usually takes about 5 hours 20 minutes, traveling roughly 802 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Syracuse, NY (SYR-Hancock Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
You can fly first class between SYR and STL. First class cabins are available on:

  • American Airlines
  • Delta Air Lines
  • United Airlines

How do I earn miles on a Syracuse, NY (SYR-Hancock Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.) flight with Expedia?
It's easy to earn miles on a Syracuse, NY (SYR-Hancock Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for St. Louis from Hancock Intl. (SYR)?
From Hancock Intl. (SYR), you can fly into Lambert-St. Louis Intl. (STL) to reach St. Louis. Some flights may connect through major hubs like Washington Dulles Intl. (IAD), Liberty Intl. (EWR), Ronald Reagan Washington National (DCA) before reaching St. Louis. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Syracuse, NY (SYR-Hancock Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.) at the last minute?
Typically, booking a last minute flight from Syracuse, NY (SYR-Hancock Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Syracuse, NY (SYR-Hancock Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.) flight and hotel package?
Securing a Syracuse, NY (SYR-Hancock Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.) St Louis Vacation Packages is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Syracuse, NY (SYR-Hancock Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
If you booked your Syracuse, NY (SYR-Hancock Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Hancock Intl.
Destination airport
Lambert-St. Louis Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
$300
Distance
801 mi

Book with confidence

Syracuse to St. Louis Flights

The cheapest times to fly from Syracuse to St. Louis

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Syracuse to St. Louis are during the month of November. You can find some of the cheapest flights from Syracuse to St. Louis with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Syracuse to St. Louis

Sunday is one of the best days to book for cheap flights from Syracuse to St. Louis: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Syracuse to St. Louis

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Syracuse to St. Louis in 2026. You can also book with separate airlines for your outbound and return journeys, from $139 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Syracuse to St. Louis flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Syracuse to St. Louis airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Syracuse to St. Louis Flights

*Flight schedules are subject to change.

*Available to One Key members.

 

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