$129 Cheap Flights from Syracuse (SYR) to St. Louis (STL)

View $129 flight on Thu, Oct 30, 2025Opens in a new window

Popular airlines from Hancock Intl. Airport (SYR) to St. Louis Lambert Intl. Airport (STL)

Cheap Flights from Syracuse to St. Louis (SYR-STL)

Prices were available within the past 7 days and start at $129 for one-way flights and $228 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frontier Airlines
Sat, Oct 11 - Sat, Oct 25
SYR
Syracuse
STL
St. Louis
$228 Roundtrip, found 11 hours ago
$228
Roundtrip
found 11 hours ago
Select Frontier Airlines flight, departing Sat, Oct 11 from Syracuse to St. Louis, returning Sat, Oct 25, priced at $228 found 11 hours ago
Frontier Airlines
Sat, Aug 23 - Thu, Aug 28
SYR
Syracuse
STL
St. Louis
$238 Roundtrip, found 4 hours ago
$238
Roundtrip
found 4 hours ago
Select Frontier Airlines flight, departing Sat, Aug 23 from Syracuse to St. Louis, returning Thu, Aug 28, priced at $238 found 4 hours ago
United
Wed, Jan 7 - Tue, Jan 20
SYR
Syracuse
STL
St. Louis
$244 Roundtrip, found 1 hour ago
$244
Roundtrip
found 1 hour ago
Select United flight, departing Wed, Jan 7 from Syracuse to St. Louis, returning Tue, Jan 20, priced at $244 found 1 hour ago
Frontier Airlines
Thu, Aug 21 - Sun, Aug 24
SYR
Syracuse
STL
St. Louis
$248 Roundtrip, found 4 hours ago
$248
Roundtrip
found 4 hours ago
Select Frontier Airlines flight, departing Thu, Aug 21 from Syracuse to St. Louis, returning Sun, Aug 24, priced at $248 found 4 hours ago
American Airlines
Wed, Jan 7 - Tue, Jan 20
SYR
Syracuse
STL
St. Louis
$249 Roundtrip, found 1 hour ago
$249
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Wed, Jan 7 from Syracuse to St. Louis, returning Tue, Jan 20, priced at $249 found 1 hour ago
Delta
Wed, Jan 7 - Tue, Jan 20
SYR
Syracuse
STL
St. Louis
$249 Roundtrip, found 1 hour ago
$249
Roundtrip
found 1 hour ago
Select Delta flight, departing Wed, Jan 7 from Syracuse to St. Louis, returning Tue, Jan 20, priced at $249 found 1 hour ago
United
Wed, Jan 7 - Tue, Jan 20
SYR
Syracuse
STL
St. Louis
$250 Roundtrip, found 1 hour ago
$250
Roundtrip
found 1 hour ago
Select United flight, departing Wed, Jan 7 from Syracuse to St. Louis, returning Tue, Jan 20, priced at $250 found 1 hour ago
American Airlines
Sat, Aug 30 - Sun, Aug 31
SYR
Syracuse
STL
St. Louis
$251 Roundtrip, found 1 day ago
$251
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Aug 30 from Syracuse to St. Louis, returning Sun, Aug 31, priced at $251 found 1 day ago
Delta
Sat, Sep 6 - Mon, Sep 22
SYR
Syracuse
STL
St. Louis
$254 Roundtrip, found 1 day ago
$254
Roundtrip
found 1 day ago
Select Delta flight, departing Sat, Sep 6 from Syracuse to St. Louis, returning Mon, Sep 22, priced at $254 found 1 day ago
United
Wed, Jan 7 - Tue, Jan 20
SYR
Syracuse
STL
St. Louis
$254 Roundtrip, found 1 hour ago
$254
Roundtrip
found 1 hour ago
Select United flight, departing Wed, Jan 7 from Syracuse to St. Louis, returning Tue, Jan 20, priced at $254 found 1 hour ago

Find the cheapest month to fly from Syracuse (SYR) to St. Louis (STL)

November is typically the cheapest month to fly

From $148 - $604 per traveler.

Graph displaying average flight prices per month

Alternative airports near St. Louis

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Lambert-St. Louis Intl. STL. Cheapest option available. Average driving time to city center is 20 minutes. Flights from $304
STL
Lambert-St. Louis Intl.
Cheapest
Average driving time to city center20 min
Flights from $304
Flights from Syracuse (SYR) to St. Louis (STL)
Origin airport
Hancock Intl.
Destination airport
Lambert-St. Louis Intl.
Airlines serving
American Airlines, Delta, Frontier Airlines, United
Roundtrip price
$228
Distance
801 mi

Syracuse to St. Louis Flights

The cheapest times to fly from Syracuse to St. Louis

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Syracuse to St. Louis are during the month of October. You can find some of the cheapest flights from Syracuse to St. Louis with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Syracuse to St. Louis

Sunday is one of the best days to book for cheap flights from Syracuse to St. Louis: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Syracuse to St. Louis

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Syracuse to St. Louis in 2025. You can also book with separate airlines for your outbound and return journeys, from $129 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Syracuse to St. Louis flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Syracuse to St. Louis airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Hancock Intl. Airport (SYR) to Lambert-St. Louis Intl. Airport (STL) cost?
Get a cheap one-way flight from $129 or cheap return flight from $228 from Hancock Intl. Airport (SYR) to Lambert-St. Louis Intl. Airport (STL) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Hancock Intl. Airport (SYR) to Lambert-St. Louis Intl. Airport (STL)?
October is the most affordable month to fly from SYR to STL. Avoiding peak travel times is often the key to scoring lower fares.
What is the cheapest airline that flies from Hancock Intl. Airport (SYR) to Lambert-St. Louis Intl. Airport (STL)?
Use the filter tool on Expedia to compare airlines and find the most affordable carrier that'll take you from SYR to STL. Then, sort your results by "Price (lowest to highest)" to score a good deal.
How many flights per day from Hancock Intl. Airport (SYR) to Lambert-St. Louis Intl. Airport (STL)?
You'll have to hop on a flight with a layover when traveling from Hancock Intl. Airport (SYR) to Lambert-St. Louis Intl. Airport (STL). Direct flights don't operate daily on this route. However, just filter your search to include one or two stops to find an option that works for you.
What day of the week has the most flights from SYR to STL?
You'll generally find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can vary from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Hancock Intl. Airport (SYR) to Lambert-St. Louis Intl. Airport (STL)?
To land at Lambert-St. Louis Intl. Airport (STL) on time, choose a flight that leaves Hancock Intl. Airport (SYR) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Hancock Intl. Airport (SYR) to Lambert-St. Louis Intl. Airport (STL) last-minute?
Booking your plane ticket from SYR to STL shortly before your trip is usually more expensive. However, if you're flexible with your schedule, you could grab a cheap last-minute fare.
Is it cheaper to book a SYR to STL flight and hotel package?
Booking a SYR to STL flight and hotel package is generally cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip all in one place. Select from our impressive range of stays and then add activities, car rentals and flights to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Hancock Intl. Airport (SYR) to Lambert-St. Louis Intl. Airport (STL)?
Typically, you can cancel or reschedule your SYR to STL flight. However, additional charges may apply, especially if you booked more than 24 hours ago. Check your itinerary for the airline's fees and policies on flight changes, or if you want further information, visit our Customer Service portal.

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*Available to One Key members.