Knoxville (TYS) to Buffalo (BUF) at a glance

Travel between Knoxville (TYS) and Buffalo (BUF) with a selection of airlines offering convenient routes for this domestic short-haul journey. Discover cheap flights from Knoxville to Buffalo, comparing various options from both full-service and low-cost carriers. This enables you to find the itinerary that aligns with your budget and travel schedule while you explore Buffalo's renowned attractions and neighborhoods. Here are the essential details for flights from McGhee Tyson Airport (TYS) to Buffalo Niagara International Airport (BUF).

• Fastest flight duration: around 3h 15m in-flight, plus roughly 1h 15m layover with one stop
• Route distance: roughly 600 miles (970 km)
• Flights per week: around 10 departures on average
• Typical fares (one-way): economy tickets often range from $110–$450, depending on seasonality and how far ahead you book

Flights from McGhee Tyson Airport (TYS) to Buffalo Niagara International Airport (BUF)

Based on recent traveler bookings, the top airlines for flights from Knoxville to Buffalo typically offer one-stop services, with popular layover options including Charlotte-Douglas International Airport (CLT) with an approximate 55-minute layover, Philadelphia International Airport (PHL) around a 1-hour layover, and Detroit Metropolitan Wayne County Airport (DTW) with about a 1 hour and 15-minute layover. This allows you the flexibility to balance price, total travel time, and cabin class while selecting the best itinerary.

• American Airlines: This major airline provides a full-service experience with one-stop flights, generally priced between $110 and $425 for one-way tickets. It represents about 59% of departures on this route, with an in-flight duration of 3 hours and 15 minutes, leading to a total travel time of approximately 4 hours and 15 minutes, including layover time.
• Delta: Offering a full-service travel option, Delta features one-stop flights with one-way fares usually between $115 and $500. It accounts for around 24% of the flights on this route, with an in-air time of 3 hours and 15 minutes, resulting in a total journey duration of about 4 hours and 15 minutes, factoring in layovers.
• United: As a full-service airline, United provides one-stop service with one-way ticket prices typically ranging from $130 to $455. It makes up about 15% of the departures on this route, with a flight time of 3 hours and 15 minutes, leading to a total travel time of roughly 4 hours and 15 minutes, including layover periods.
• Southwest Airlines: This budget airline offers one-stop service, with one-way fares generally falling between $170 and $330. Southwest accounts for about 2% of the flights on this route, featuring an in-flight duration of 3 hours and 15 minutes, which results in a total journey time of approximately 4 hours and 15 minutes, including layovers.

Travelers flying from Knoxville to Buffalo have the option to upgrade their flight, with Delta providing first-class service on this route.

Best time to fly from Knoxville (TYS) to Buffalo (BUF)

The most popular months for travelers flying from Knoxville to Buffalo are April, May, and August, when peak temperatures in Buffalo reach up to 70.7°F in August. If you prefer quieter travel, consider September, the least busy and relatively cheaper time to visit with fewer crowds and temperatures around 64.6°F. For better deals, August usually offers the lowest average one-way fare around $195. Flight availability peaks in May, with approximately 13 flights per week, making it easier to find convenient departure times. December has the fewest flights, with approximately 7 flights per week.

• Cheapest time to fly: August usually offers good deals with average one-way fare around $195, roughly 19% cheaper than the yearly average.
• More budget-friendly months to fly: September and July typically offer average one-way fares of around $212.
• Most flight options: May has the highest number of flights from Knoxville to Buffalo, with approximately 13 flights per week, giving you more flexibility in scheduling your trip.

Month	Temperature	Demand	Weekly Flights	Average one-way Fare
January	25.5°F (-3.6°C)	Average	10	$292
February	26.1°F (-3.3°C)	Average	8	$265
March	34.3°F (1.3°C)	Average	8	$255
April	45.0°F (7.2°C)	High	9	$253
May	57.7°F (14.3°C)	High	13	$235
June	66.0°F (18.9°C)	Average	10	$238
July	72.0°F (22.2°C)	Average	10	$213
August	70.7°F (21.5°C)	High	11	$195
September	64.6°F (18.1°C)	Low	12	$211
October	53.2°F (11.8°C)	Average	11	$249
November	41.4°F (5.2°C)	Low	11	$256
December	33.1°F (0.6°C)	Low	7	$228

*Average one-way fare is based on Expedia flight booking data from January 2025 to April 2026 for the specified route and travel class and may change depending on availability, dates, and demand.

Alternative route from Knoxville (TYS) to Buffalo (BUF)

• Knoxville to Rochester (TYS-ROC): Greater Rochester International Airport (ROC) is located approximately 56 miles from Buffalo Niagara International Airport (BUF). One-way economy tickets for this route generally fall between $125 and $425, influenced by the season and how far in advance you secure your booking. Travelers often find one-stop flight options, with common layover points including Ronald Reagan Washington National Airport (DCA) and LaGuardia Airport (LGA). Major airlines servicing this route are American Airlines and Delta, with first-class service also available.

How to find the best prices for flights from Knoxville (TYS) to Buffalo (BUF)

Getting some of the best deals on flights from Knoxville to Buffalo is all about timing and flexibility. Here are some key tips to help you save:

1. Best times to book and fly: cheaper fares are typically found when booking 2-8 weeks in advance, which coincides with when most travelers make their reservations. Afternoon departures (12pm-6pm) often provide better prices, even though morning flights (5am-12pm) are more popular. Additionally, flying on Saturday usually results in lower costs, while Sunday remains the busiest travel day.
2. Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
3. Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.*
4. Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
5. Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
6. Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.

*Members only. Savings vary and are not available on all bundles. Select hotels.

Arriving at Buffalo Niagara International Airport from McGhee Tyson Airport

Buffalo welcomes travelers from Knoxville with a range of transport options based on price, convenience, and proximity. For departures, McGhee Tyson Airport is roughly a 20-minute drive (covering about 15 miles) from central Knoxville. Here's how to reach Buffalo efficiently:

• Hotel transfer: Transfers offer a convenient way to reach your hotel in Buffalo, with private rides that can be arranged in advance.
• Car rental: Renting a car from Buffalo Niagara International Airport is a great option if you plan to explore and sightsee beyond the city. Browse cheap car rentals at Buffalo Niagara International Airport on Expedia.
• Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.
• Public transportation: From Buffalo Niagara International Airport, Buffalo-Depew Station, a train station, is located about 2.6 miles away by car, while University Station, a metro station, is situated approximately 6.5 miles from the airport, both accessible by car.