If you're craving some mental stimulation, spend an afternoon at Byzantine Museum. Whether it's history, culture or beliefs, you'll find lots of interesting displays to keep you entertained here.
Situated in Ioannina Town Centre, this collection of historical artifacts is well worth including on your itinerary. But you'll find loads more to check out in this area. Ioannina Castle, Perama Cave, and Ali Pasha Residence aren't too far from Byzantine Museum.