One of your first stops should be Chokoloskee Bay. Here, you'll be able to orient yourself and get some great ideas before you set out exploring.
This Everglades City tourist information center is an interesting spot to begin your day of sightseeing. There's loads to see close by, including Everglades City Hall, and Museum of the Everglades. Wander around at your leisure at Chokoloskee Bay before making tracks to these other fine sights.