San Francisco Vacations

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Your San Francisco Vacation

Say bye-bye to planning worries and hello to a San Francisco vacation package. With the finer details organized before you go, you can focus on discovering the best of this city, starting with El Cangrejo, which is good for distilleries and craft breweries, bars and pubs and cafes. Make your trip to San Francisco even more fun and exciting by going sightseeing. Bridge of the Americas, Miraflores Locks and Metropolitan Cathedral of Panama are among the most popular attractions worth exploring. Whoever you're escaping with and whatever you plan to spend, your dream San Francisco vacation is just a few clicks away with Expedia.

The Latest San Francisco Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Save 100% on your flight
per person
Aug 7 - Aug 13
Roundtrip flight included
Newark (EWR) to Panama City (PTY)
9/10 Wonderful! (682 reviews)
Best place to stay in the old town.

Reviewed on May 21, 2024

Dreams Playa Bonita Panama - All Inclusive

Dreams Playa Bonita Panama - All Inclusive

4 out of 5
per person
Aug 7 - Aug 13
Roundtrip flight included
Newark (EWR) to Panama City (PTY)
7.4/10 Good! (973 reviews)
We had a wonderful experience here. The staff was very attentive and accommodating to myself and my wife. Adalberto, Cindy, Giovanna, Marcos, Ruben, Nick. Carlos and the list go on and on. This staff members treated us like family. I know a missed quite a few names from the Queen as we called her at the front desk, Veronica the concierge to Emmanuel our driver. Everyone made our first stay in Panama amazing. We cannot leave out the bar tender in the hotel Lobby. He presented us with gifts, professionalisms and a great time. We cannot express our heartfelt appreciation enough. So, we thank you for a wonderful experience at Dreams Playa Bonita Panama. If your time was not filled with joy, it's your fault. God Bless everyone. The Jacksons.

Reviewed on May 20, 2024

Isla Palenque Member of the Cayuga Collection

Isla Palenque Member of the Cayuga Collection

4 out of 5
Save 100% on your flight
per person
Jun 30 - Jul 5
Roundtrip non-stop flight included
New York (JFK) to Panama City (PTY)
10/10 Exceptional! (6 reviews)
Absolutely incredible time!

Reviewed on May 7, 2024

Hotel Panamonte

Hotel Panamonte

3.5 out of 5
per person
Jun 30 - Jul 5
Roundtrip non-stop flight included
New York (JFK) to Panama City (PTY)
9.4/10 Exceptional! (65 reviews)
Beautiful gardens and great restaurant with excellent food service. The bedding /sheets were clean and fine, but the bathroom needed more cleaning.

Reviewed on May 13, 2024

La Coralina Island House

La Coralina Island House

3.5 out of 5
per person
Jul 25 - Jul 30
Roundtrip flight included
New York (NYC) to Panama City (PTY)
9.4/10 Exceptional! (44 reviews)
Very difficult to get around because of the only unpaved road. The resort was fine. If you go there, plan on staying 3-4 days because it’s very hard to get to due to the only bumpy road.

Reviewed on May 17, 2024

Where to stay in San Francisco

Find the best San Francisco areas and neighborhoods for the activities you enjoy most. Learn more about San Francisco
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Casco Viejo

4.5/5(178 area reviews)

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Metropolitan Cathedral of Panama or National Theater while you're exploring the area.

Find hotel + flight trips in Casco Viejo

San Francisco Hotel Deals

Megapolis Hotel Panamá
Megapolis Hotel Panamá
4.5 out of 5
Avenida Balboa, Panama City
Fully refundableReserve now, pay when you stay
The price is $128 per night from May 23 to May 24
$128
$140 total
includes taxes & fees
May 23 - May 24
8.2/10 Very Good! (406 reviews)
"Excellent service The people very nice"

Reviewed on May 16, 2024

Megapolis Hotel Panamá
Decapolis Hotel Panama City
Decapolis Hotel Panama City
4 out of 5
Avenida Balboa Con Multicentro, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is $77 per night from May 26 to May 27
$77
$85 total
includes taxes & fees
May 26 - May 27
8.4/10 Very Good! (1,014 reviews)
"Staff very friendly. Rooms in need of renovation."

Reviewed on May 18, 2024

Decapolis Hotel Panama City
Plaza Paitilla Inn Hotel
Plaza Paitilla Inn Hotel
3.5 out of 5
Italy Avenue, Punta Paitilla, Winston Churchill Street, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is $117 per night from May 23 to May 24
$117
$129 total
includes taxes & fees
May 23 - May 24
9/10 Wonderful! (1,392 reviews)
"Great place , staff and super breakfast"

Reviewed on May 19, 2024

Plaza Paitilla Inn Hotel
See all 1,278 properties in San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Explore other types of vacation packages

All Inclusive Vacations

All Inclusive Vacations

Beach Vacations

Beach Vacations

Kid Friendly Vacations

Kid Friendly Vacations

Frequently asked questions

How much does a San Francisco vacation package cost?
Much less than you might think — from a low $968, in fact! By bundling hotels, flights and car rentals into a custom-built vacation package, your San Francisco escape is only clicks away.
How do I get a cheap travel package to San Francisco?
Lock in flights that suit your schedule, add a hotel to your booking and watch how much you save with a San Francisco vacation package. It’s that easy! From flights and hotels to rental cars and activities, Expedia makes traveling on the cheap easy. And with more than 550 partner airlines and 1,000,000 hotel options around the globe to pick from, you’ll never be short of choice.
Where should I stay in San Francisco?
Make sightseeing easy by staying near San Francisco’s main attractions. Miraflores Locks and Metropolitan Cathedral of Panama are two which top many visitors’ bucket lists.
What are the top hotels in San Francisco?
If this will be your first visit to San Francisco, secure a room at Sublime Apartment City Center. Ph Boutique Quartier Atlapa or New Cozy Apartment Ocean View. Quartier Del Mar. Both hotels will make you feel at home and are popular options with lots of travelers.
How far in advance should I book my San Francisco vacation?
It can be hard to know when is the ideal time to book your trip to San Francisco. But typically the earlier you book, the lower the prices. Sometimes, you can reserve your flights and hotels up to a year prior to your departure date. If you’re eager to escape on a last-minute getaway, no need to fret! There are unbeatable deals announced on Expedia every day.
What does an Expedia San Francisco travel package include?
That mostly depends on you. You can choose from a range of San Francisco packages, such as a hotel, rental car and flight. You can also book a hotel and a flight, or a flight and a rental car. Once you’ve made your booking, you can add the fun stuff like experiences and tours. Whatever your ideal San Francisco vacation looks like, you’re sure to save!
What should I know before booking a San Francisco travel package?
So many places to go, so many things to see and do. With a travel package, you’ll be able to afford more of them. Bundle your hotels, flights and rental cars and land big savings.
Can I choose my airline with a San Francisco Expedia vacation package?
Yes, definitely. Expedia has more than 550 airline partners to choose from worldwide. With such a huge range of choice, finding the ideal carrier to whisk you off to San Francisco won’t be difficult.
If I'm not able to travel, can I cancel my San Francisco vacation package?
Your situation can change in a flash, so yes, you can. You may be able to amend or cancel your San Francisco vacation package for free if you’ve booked in the last 24 hours. For older bookings, you can still make changes, but your car rental company, airline or hotel may charge a fee. Need more information? Look up our Customer Service Portal. We’ll help make sure your trip goes off without a hitch.

Discover the most popular places to visit in San Francisco

Image for Multiplaza Pacific Mall

Multiplaza Pacific Mall

4.5/5(634 reviews)

During your trip to Panama City, you can enjoy retail therapy at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.

Multiplaza Pacific Mall
Image for ATLAPA Conventions Center

ATLAPA Conventions Center

3.5/5(21 reviews)

Learn about the events happening at ATLAPA Conventions Center during your trip to Panama City. Stroll along the seaside in this vibrant area, or check out its lively bars.

ATLAPA Conventions Center
Image for Multicentro Panama

Multicentro Panama

4/5(148 reviews)

During your trip to Panama City, you can find the perfect gifts to bring home at Multicentro Panama. Stroll along the seaside or visit the casinos in this vibrant area.

Multicentro Panama

Things to do

Image for Eco Boat Canal Cruise & Monkey Habitat Tour

Eco Boat Canal Cruise & Monkey Habitat Tour

$85
Per adult
Eco Boat Canal Cruise & Monkey Habitat Tour
Image for Live the Experience of a Full Day in San Blas

Live the Experience of a Full Day in San Blas

$165
Per adult
100% of travellers recommend
Live the Experience of a Full Day in San Blas
Image for 1- or 2-Night Experience in San Blas Islands

1- or 2-Night Experience in San Blas Islands

$260
Per adult
1- or 2-Night Experience in San Blas Islands
See all activities in Panama City

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.