You may spot Sao Jose Cathedral in the skyline before you actually find this amazing place of worship. Peek inside if it's open or just appreciate the facade from the street.
You're spoiled for sightseeing choice in São José do Rio Preto. Sao Jose Cathedral is a great place to start here, but there are numerous other worthy sights to discover. CEASA Public Market, Rio Preto Shopping Center, and Plaza Avenida Shopping Center are near the principal church and and will cap off your day nicely.