A coastal fortress with a stone wall and a tiled-roof building.

Find 4 Star Hotels in Syracuse from $87

Check availability on Syracuse 4 Star Hotels

Tonight
Sep 4 - Sep 5
Tomorrow
Sep 5 - Sep 6
This weekend
Sep 4 - Sep 6
Next weekend
Sep 11 - Sep 13

Our top choices for Syracuse 4-star hotels

A historic building with a central entrance, multiple balconies, and a large potted plant in front.
A spacious living area with a large mirror, a chandelier, and a fireplace. There are multiple seating options including a sofa and chairs.
An interior corridor with an arched stone doorway, a staircase, and a table with a vase of flowers.
An interior view of a restaurant with stone arches, wooden beams, and tables set for dining.

1. Algila' Ortigia Charme Hotel

Algila' Ortigia Charme Hotel
Ortigia
United Kingdom
Rachael
$340 nightly
$385 total
Sep 15 - Sep 16
Total with taxes and fees
Algila' Ortigia Charme Hotel
A historic building with ornate balconies, a grand entrance, and flags of the European Union and Italy.
A spacious living room with a large sofa, two armchairs, a dining area with a table and chairs, and a kitchen in the background.
A spacious outdoor seating area with wicker furniture, potted plants, and a view of the building's interior.
A buffet with various food items and condiments.

2. Grande Albergo Alfeo

Grande Albergo Alfeo
Santa Lucia
Australia
Janet
$115 nightly
$131 total
Sep 23 - Sep 24
Total with taxes and fees
Grande Albergo Alfeo
A bakery display with various baked goods and a sign indicating apple and jam cake.
An outdoor patio area with seating and potted plants, under a night sky.
A hallway with a stone wall, a wooden door, and a purple-lit wall.
A spa area with a reflective pool, a candlelit candelabra, and a cave-like wall.

3. UNA Hotels One Siracusa Wellness & SPA

UNA Hotels One Siracusa Wellness & SPA
Grottasanta
United States
Tanasha
$137 nightly
$156 total
Oct 4 - Oct 5
Total with taxes and fees
UNA Hotels One Siracusa Wellness & SPA
A poolside setting with a person relaxing, a table with a drink and fruit, and a view of the pool and chairs in the background.
A courtyard with tables set up for an event, surrounded by buildings with large windows and a well-lit exterior.
A buffet with various food items, including pastries and a meat display, in a well-lit room with a neutral color scheme.
A pathway leading through a garden with large planters and tall conical lights.

4. Hotel Parco delle Fontane

Hotel Parco delle Fontane
Tiche
United States
Tony
$145 nightly
$166 total
Sep 13 - Sep 14
Total with taxes and fees
Hotel Parco delle Fontane
A large, multi-story building with a grand staircase leading to the entrance, stone walls, and multiple illuminated windows.
An outdoor seating area with tables and chairs, a large tree, and a building with a tiled roof.
A waterfront promenade with clear water, a stone walkway, and a row of beach umbrellas.
A swimming pool with water features, outdoor seating, and a bar area.

5. Dolce by Wyndham Siracusa I Monasteri Golf & Spa

Dolce by Wyndham Siracusa I Monasteri Golf & Spa
Syracuse
United States
Myrnalyn
$86 nightly
$98 total
Sep 21 - Sep 22
Total with taxes and fees
Dolce by Wyndham Siracusa I Monasteri Golf & Spa
A woman holding a wine glass on a balcony overlooking a street with historic buildings and a clock tower.
A bar with a stone ceiling, a marble countertop, and shelves stocked with liquor bottles.
A building with three balconies, a central entrance with an archway, and a sign indicating it is a small luxury hotel.
A grand lobby with arched ceilings, marble columns, a chandelier, and a reception desk.

6. Palazzo Artemide - VRetreats, SLH Collection

Palazzo Artemide - VRetreats, SLH Collection
Ortigia
United States
Victor
$371 nightly
$419 total
Sep 27 - Sep 28
Total with taxes and fees
Palazzo Artemide - VRetreats, SLH Collection
A coastal terrace with wicker furniture, striped umbrellas, and a rocky backdrop.
A grand staircase with marble steps and red carpet, flanked by wooden balustrades and potted plants, leading to a room with ornate decor and a chandelier.
A swimming pool with lounge chairs and umbrellas, surrounded by buildings with a staircase and a view of the city skyline.
A grand lobby with a central red seating area, a staircase, and a high ceiling with skylights.

7. Grand Hotel Villa Politi

Grand Hotel Villa Politi
Grottasanta
France
abdulrahman
$184 nightly
$210 total
Sep 6 - Sep 7
Total with taxes and fees
Grand Hotel Villa Politi
A spacious restaurant with high wooden ceilings and large windows.
A modern multi-story hotel with a glass facade, a visible entrance with a sign, and a balcony area.
A nighttime pool area with a clear view of the pool, lounge chairs, and umbrellas.
A modern dining area with round tables and chairs, large windows with sheer curtains, and pendant lighting.

8. Mercure Siracusa Prometeo

Mercure Siracusa Prometeo
Neapolis
United States
John
$144 nightly
$175 total
Oct 2 - Oct 3
Total with taxes and fees
Mercure Siracusa Prometeo
A riverside walkway with people walking and sitting, overlooking a body of water.
A bedroom with a stone wall, a bed with a headboard, a desk, a chair, a television, and a window with a view of the sea.
A view from an open window overlooking a body of water with a distant shoreline.
A stone staircase with a large urn on the landing, leading to a balcony with a metal railing overlooking the sea.

9. Charme Hotel Henry's House

Charme Hotel Henry's House
Ortigia
United States
Komal
$351 nightly
$398 total
Sep 5 - Sep 6
Total with taxes and fees
Charme Hotel Henry's House
A poolside breakfast setup with a newspaper, fruit bowl, juice, and coffee.
A modern dining area with multiple tables and chairs, a kitchen in the background, and decorative plants.
A terrace with outdoor seating, a table with food and drinks, and potted plants.
A spacious living area with a modern design, featuring a sofa set, a coffee table, and a bookshelf.

10. Albatros Hotel

Albatros Hotel
Syracuse
United Kingdom
lynda
$95 nightly
$109 total
Oct 5 - Oct 6
Total with taxes and fees
Albatros Hotel
A nighttime pool area with lounge chairs and umbrellas, surrounded by palm trees and a building with balconies.
An outdoor covered patio area with tables and chairs, a stone wall, and a palm tree.
A buffet with various fruits and pastries.
A modern hotel lobby with a long reception desk, multiple seating areas, and large windows offering views of the outdoors.

11. Eureka Palace Hotel Spa

Eureka Palace Hotel Spa
Syracuse
Ireland
Sharon
$76 nightly
$87 total
Oct 4 - Oct 5
Total with taxes and fees
Eureka Palace Hotel Spa
A beach with white umbrellas and lounge chairs arranged in rows.
A spacious indoor area with high ceilings and large windows, featuring multiple seating arrangements and a modern design.
A spacious dining area with multiple tables set for dining, large windows allowing natural light, and a modern ceiling design.
An aerial view of a resort with two swimming pools, a beach, and a coastal backdrop.

12. VOI Arenella Resort

VOI Arenella Resort
Syracuse
United States
Frank
VOI Arenella Resort
A swimming pool with a curved edge, surrounded by lounge chairs and umbrellas, with buildings and palm trees in the background.
A view through a window of a landscape with trees and a clear sky.
An aerial view of a coastal residential area with a row of houses, a swimming pool, and a clear view of the ocean.
A hotel room with a neatly made bed, a bedside lamp, and a window with curtains.

13. Residence Archimede

Residence Archimede
Syracuse
United States
Anthony
$123 nightly
$140 total
Oct 4 - Oct 5
Total with taxes and fees
Residence Archimede
A swimming pool with a tiled deck, a covered seating area with tables and chairs, and a building with a green roof in the background.
A hallway with a tiled floor, a staircase, and a reception desk.
A two-story building with a flat roof, a balcony on the second floor, and a paved driveway leading to the entrance.
An outdoor dining area with round tables and chairs, a pool, and a view of a building in the background.

14. Villa Fanusa

Villa Fanusa
Syracuse
United Kingdom
J
$87 nightly
$100 total
Oct 3 - Oct 4
Total with taxes and fees
Villa Fanusa
A clear view of a beach with rocky formations in the water.
A table set with various foods and drinks, including a bottle of champagne, plates of appetizers, and glasses of water and juice, by a poolside.
A garden pathway leading to a sign that reads "Rooms Beach."
A table set with a plate of food, a glass of orange juice, a glass of red drink, a white vase, and a cup.

15. Hotel Villamare

Hotel Villamare
Syracuse
United Kingdom
Ceri
$188 nightly
$214 total
Oct 4 - Oct 5
Total with taxes and fees
Hotel Villamare
A stone pathway leading to a sunset view, flanked by lanterns and greenery.
An aerial view of a resort with a large, uniquely shaped swimming pool surrounded by lounge areas and palm trees.
A cozy living room with a white sofa, a wooden coffee table with newspapers, and a bookshelf filled with books.
A modern, compact hotel room with a kitchenette, a small dining area, and a bed with a striped pillow.

16. Borgo Pantano

Borgo Pantano
Syracuse
United Kingdom
Christopher
$186 nightly
$212 total
Sep 29 - Sep 30
Total with taxes and fees
Borgo Pantano
A swimming pool with lounge chairs and umbrellas, surrounded by buildings with arched windows and palm trees.
A view through an arched window of a residential area with a swimming pool, parked cars, and palm trees.
A dining area with multiple tables and chairs, a variety of wine bottles on display, and a large window providing natural light.
A hotel with a courtyard featuring outdoor seating and umbrellas, surrounded by palm trees and a well-maintained lawn.

17. Hotel Relax

Hotel Relax
Epipoli
United Kingdom
Fabrizio
$143 nightly
$163 total
Oct 4 - Oct 5
Total with taxes and fees
Hotel Relax
A pool with a view of the sea, surrounded by lounge chairs and a wooden deck.
A coastal building with multiple balconies and a stone staircase leading up to it.
A stone staircase leading to a scenic overlook with a view of the sea, surrounded by lush greenery and a tiled wall with colorful artwork.
A bedroom with a large bed, a nightstand, a chair, and a painting on the wall.

18. La Rosa sul Mare

La Rosa sul Mare
Syracuse
Denmark
Lene
$148 nightly
$169 total
Sep 7 - Sep 8
Total with taxes and fees
La Rosa sul Mare
A spacious patio area with a view of the city skyline, featuring modern furniture and potted plants.
A spacious living area with a wooden ceiling, a staircase, a red sofa, and a potted plant.
An indoor swimming pool with blue and red lighting, surrounded by walls and a glass window.
A hotel entrance with a metal archway, double doors, and two potted plants.

19. Hotel Centrale

Hotel Centrale
Syracuse
United Kingdom
Philippa
$150 nightly
$171 total
Sep 10 - Sep 11
Total with taxes and fees
Hotel Centrale

20. Aretusa Palace Hotel

Aretusa Palace Hotel
Syracuse
Italy
Vincenzo
Aretusa Palace Hotel
Save an average of 15% on thousands of hotels when you're signed in

Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Syracuse.
Ortea Palace Hotel, Sicily, Autograph Collection

Ortea Palace Hotel, Sicily, Autograph Collection

Via Riva Nazario Sauro Syracuse SR
$506 nightly
$568 total
Sep 6 - Sep 7
Total with taxes and fees
Ortea Palace Hotel, Sicily, Autograph Collection
Grand Hotel Ortigia Siracusa

Grand Hotel Ortigia Siracusa

Viale Mazzini, 12 Syracuse SR
$328 nightly
$372 total
Oct 4 - Oct 5
Total with taxes and fees
9/10 Wonderful! (622 reviews)
Grand Hotel Ortigia Siracusa
Grand Hotel Des Ètrangers - The Leading Hotels of the World

Grand Hotel Des Ètrangers - The Leading Hotels of the World

Passeggio Adorno 10/12 Syracuse SR
$640 nightly
$716 total
Sep 20 - Sep 21
Total with taxes and fees
Grand Hotel Des Ètrangers - The Leading Hotels of the World
Still don't see what you're looking for?
See all properties in Syracuse.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Syracuse

Ancient Greek ruins in the Archaeological Park include the impressive Teatro Greco where summer performances still take place. Wander through Ortygia's narrow streets to discover the Duomo, built around a former Greek temple with columns still visible from inside.

See all hotels in Syracuse
An ancient amphitheater with stone ruins and a grassy field.

Top Syracuse Hotel Reviews

Algila' Ortigia Charme Hotel

Algila' Ortigia Charme Hotel

10/10 Excellent
"Rooms are very unique and not one is the same. Very charming rooms and buildings. Hotel provides a great breakfast with cook to order service. Staff was truly amazing so helpful in every way. Great place to stay. Location to town square about 7 minute walk! Highly recommend!!"
Paul 3-night trip
Posted 6 hours ago
Algila' Ortigia Charme Hotel
Mercure Siracusa Prometeo

Mercure Siracusa Prometeo

8/10 Good
"Très bel hôtel et personnel cpurypid"
caroline 2-night trip
Posted 2 days ago
Mercure Siracusa Prometeo
Palazzo Artemide - VRetreats, SLH Collection

Palazzo Artemide - VRetreats, SLH Collection

10/10 Excellent
"Great experience with an amazing and very helpful staff!"
Brigyte 2-night trip
Posted 2 days ago
Palazzo Artemide - VRetreats, SLH Collection
Dolce by Wyndham Siracusa I Monasteri Golf & Spa

Dolce by Wyndham Siracusa I Monasteri Golf & Spa

10/10 Excellent
"Beautiful room and friendly service."
Myrnalyn 2-night trip
Posted 7 days ago
Dolce by Wyndham Siracusa I Monasteri Golf & Spa
Hotel Parco delle Fontane

Hotel Parco delle Fontane

10/10 Excellent
"Please clarify the specific procedures or instructions for gaining access to the facility, particularly regarding the address displayed at the gate."
Salvatore 1-night trip
Posted 10 days ago
Hotel Parco delle Fontane
Grande Albergo Alfeo

Grande Albergo Alfeo

10/10 Excellent
"Great spot in Siracusa and easy walk into Ortigia. The staff was friendly and Alessandro was a great help to us and answered our questions in English and Italian. Plus who can resist the refreshingly delicious free granita."
Elizabeth 3-night trip
Posted 11 days ago
Grande Albergo Alfeo
UNA Hotels One Siracusa Wellness & SPA

UNA Hotels One Siracusa Wellness & SPA

10/10 Excellent
"It’s a really beautiful hotel. Great staff, great food, AC works, beautiful spa. It’s in central place but not in the midst of all the chaos at the same time!"
Tanasha 2-night trip
Posted 2 months ago
UNA Hotels One Siracusa Wellness & SPA

Find out more about Syracuse

The outset of any holiday gets started with picking a location. Syracuse is a popular option with tourists because of everything it offers. Location is everything, but that accounts for more than the area you are flying into. Now that you have got a feeling for this city, it's time you to get to know your residence for the next several days.

Properties as Scenic as the City

Syracuse saw its fair share of visitors in the last year. Expedia's review section features tips and tricks on which accommodation will satisfy your desires for a wonderful vacation. The resorts found here aim to make your stay as gratifying as your days and nights hanging out in Syracuse. These hotels aim to make the grounds and facilities welcoming during your stay. You won't have to search long for to keep up with your exercise schedule, an invigorating spa treatment, or nice dinner.

Rooms have been designed to keep you as comfortable as possible, with amenities like ultra-comfortable bedding, designer bathroom products, and in-room coffee or tea. So, lay back and relax. Moreover, if you find that you're need of anything further, you can rest assured the staff will do their best to ensure you remain satisfied during your time. These properties are so lovely that you'll regret the day you have to check-out.

Book a 4-Star Hotel in Syracuse Today!

A holiday to Syracuse should be one where you won't have to concern yourself about the little things. With Expedia, you can get great deals on world-class accommodations to take your trip to the next level.

Frequently asked questions

What are the best 4-star hotels in Syracuse?
Look forward to 4-star hotel comfort at Algila Ortigia Charme Hotel. Rated highly by many of our guests, it comes with concierge services and room service. Also take a look at Hotel Roma. Premium bedding and concierge services help make this retreat another popular pick in Syracuse.
How much does it cost to stay in a 4-star hotel in Syracuse?
With Expedia's sort and search filters, locking in a superb deal on a 4-star hotel in Syracuse just got simpler. Start by keying in your chosen travel dates and length of your trip. Then sort the results by price and pick the option that best suits your budget and style.
  • Search for the lowest price from $372
What's the difference between 5-star and 4-star hotels in Syracuse?
Offering an inviting traveler experience and upscale décor, 4-star hotels are a fabulous option for your Syracuse vacation. These kinds of accommodations generally come with lots of handy amenities that make it simple to kick back and relax — think complimentary bathrobes, gyms and pools. Or live in the lap of luxury at a 5-star hotel designed to spoil you with high-end perks and amenities. A personalized service, oversized bathrooms and world-class dining are typically featured at these plush retreats.

Explore a world of travel with Expedia