Title: Effingham Vacation Rentals from $196: Search Short-Term Rentals | Expedia.com

[Hotels in Effingham](https://expedia.com/Effingham-Hotels.d553248635975849973.Travel-Guide-Hotels)[Car Rentals in Effingham](https://expedia.com/Car-Rentals-In-Effingham.d553248635975849973.Car-Rental-Guide)[Effingham Vacation Packages](https://expedia.com/Effingham.d553248635975849973.Destination-Travel-Guides)

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## Check prices for these dates

In two weeks

[Mar 13 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=553248635975849973&startDate=2026-03-13&endDate=2026-03-15&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[Apr 24 - Apr 26](https://www.expedia.com/Hotel-Search?regionId=553248635975849973&startDate=2026-04-24&endDate=2026-04-26&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In three months

[May 22 - May 24](https://www.expedia.com/Hotel-Search?regionId=553248635975849973&startDate=2026-05-22&endDate=2026-05-24&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In four months

[Jun 19 - Jun 21](https://www.expedia.com/Hotel-Search?regionId=553248635975849973&startDate=2026-06-19&endDate=2026-06-21&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Effingham vacation rentals

![1 bedroom, iron/ironing board, travel crib, free WiFi](https://images.trvl-media.com/lodging/96000000/95030000/95026900/95026870/e767c5d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/96000000/95030000/95026900/95026870/ba3e11be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/96000000/95030000/95026900/95026870/74a4cc64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/96000000/95030000/95026900/95026870/08dcc409.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cottage in Sellers

[](https://www.expedia.com/Sellers-Hotels-Charming-Cottage-With-Easy-Access-To-Local-Attractions-Pet-And-Kid-Friendly.h95026870.Hotel-Information)

9.6/10

Exceptional

(23 reviews)

"So charming. The hostess is very accommodating and willing. We felt very welcome. All the accoutrements are tasteful. We had plenty of what we needed for our little celebration. Not too far of a skirt to Flo-town for a bite and some dessert. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Benjamin

$180 nightly

$196 total

Mar 1 - Mar 2

Total with taxes and fees

[](https://www.expedia.com/Sellers-Hotels-Charming-Cottage-With-Easy-Access-To-Local-Attractions-Pet-And-Kid-Friendly.h95026870.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/125000000/124500000/124497200/124497136/58e89181.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/125000000/124500000/124497200/124497136/8a82536c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/125000000/124500000/124497200/124497136/01a0adf6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/125000000/124500000/124497200/124497136/835fbd1a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Mobile Home in Latta

[](https://www.expedia.com/Latta-Hotels-The-Pinecone-Retreat-Only-1-Mile-From-I95.h124497136.Hotel-Information)

$128 nightly

$140 total

Feb 26 - Feb 27

Total with taxes and fees

[](https://www.expedia.com/Latta-Hotels-The-Pinecone-Retreat-Only-1-Mile-From-I95.h124497136.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/c148491e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, books, printers](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/24f777ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/ad5ff8fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/d862c686.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Florence

[](https://www.expedia.com/Florence-Hotels-Walking-Distance-From-One-Of-South-Carolinas-Top-Medical-Centers.h79668437.Hotel-Information)

9.8/10

Exceptional

(43 reviews)

"Everything was great!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Debra B.

$207 nightly

$232 total

Mar 2 - Mar 3

Total with taxes and fees

[](https://www.expedia.com/Florence-Hotels-Walking-Distance-From-One-Of-South-Carolinas-Top-Medical-Centers.h79668437.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/34000000/33750000/33743000/33742964/8b91a232.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV, fireplace, video games, DVD player](https://images.trvl-media.com/lodging/34000000/33750000/33743000/33742964/5beed59d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/34000000/33750000/33743000/33742964/281cef30.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/34000000/33750000/33743000/33742964/61eb4d8c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cabin in Marion

[](https://www.expedia.com/Marion-Hotels-Secret-SC-Cabin-On-100-Acres-Hot-Tub-Large-Pond.h33742964.Hotel-Information)

9.6/10

Exceptional

(181 reviews)

"Our stay at Rodney’s cabin was just what we needed... Some time alone on 100 acres. Other than the peaceful sound of the waterfall trickling to the pond, Mother Nature and animals can only be heard. The cabin is equipped with everything you need to enjoy your stay as you reconnect with one another and the great outdoors. Bring whatever flavors you like and learn to cook together on a Big Green Egg that Rodney has built into his outdoor kitchen!! We relaxed in the hot tub each night and can’t...

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

michael l.

$432 nightly

$470 total

Mar 1 - Mar 2

Total with taxes and fees

[](https://www.expedia.com/Marion-Hotels-Secret-SC-Cabin-On-100-Acres-Hot-Tub-Large-Pond.h33742964.Hotel-Information)

![Microwave, oven, stovetop, dishwasher](https://images.trvl-media.com/lodging/114000000/113650000/113648000/113647916/a9ad6210.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, iron/ironing board, travel crib, WiFi](https://images.trvl-media.com/lodging/114000000/113650000/113648000/113647916/bb4cb484.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/114000000/113650000/113648000/113647916/b4772b44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/114000000/113650000/113648000/113647916/245d30d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Hartsville

[](https://www.expedia.com/Hartsville-Hotels-Charming-2-Bedroom-Apartment-MINUTES-From-Darlington-Raceway-With-Pond-Views.h113647916.Hotel-Information)

10/10

Exceptional

(9 reviews)

"Sooo good. Peaceful country setting yet close to everything. We will definitely try staying here again next time."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Randy W.

$387 nightly

$422 total

Mar 22 - Mar 23

Total with taxes and fees

[](https://www.expedia.com/Hartsville-Hotels-Charming-2-Bedroom-Apartment-MINUTES-From-Darlington-Raceway-With-Pond-Views.h113647916.Hotel-Information)

![Dining](https://images.trvl-media.com/lodging/88000000/87660000/87657300/87657259/90a72a60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Living area](https://images.trvl-media.com/lodging/88000000/87660000/87657300/87657259/b4721f87.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Private kitchen](https://images.trvl-media.com/lodging/88000000/87660000/87657300/87657259/94a0d867.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/88000000/87660000/87657300/87657259/8f4ad967.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Marion

[](https://www.expedia.com/Marion-Hotels-Located-In-Marion-Only-1-Hour-From-Myrtle-Beach.h87657259.Hotel-Information)

9.0/10

Wonderful

(6 reviews)

"It was a great place. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Cindy N.

$549 nightly

$598 total

Feb 26 - Feb 27

Total with taxes and fees

[](https://www.expedia.com/Marion-Hotels-Located-In-Marion-Only-1-Hour-From-Myrtle-Beach.h87657259.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/123000000/122690000/122683200/122683191/48ab0078.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/123000000/122690000/122683200/122683191/d5fef904.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/123000000/122690000/122683200/122683191/fa8515b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/123000000/122690000/122683200/122683191/c60efe7a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Florence

[](https://www.expedia.com/Florence-Hotels-Perfect-Stop-Near-I-95.h122683191.Hotel-Information)

9.6/10

Exceptional

(5 reviews)

$243 nightly

$272 total

Feb 26 - Feb 27

Total with taxes and fees

[](https://www.expedia.com/Florence-Hotels-Perfect-Stop-Near-I-95.h122683191.Hotel-Information)

![Dining](https://images.trvl-media.com/lodging/124000000/123130000/123127500/123127484/c3d44dee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/124000000/123130000/123127500/123127484/d9622cff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/124000000/123130000/123127500/123127484/5d047f8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/124000000/123130000/123127500/123127484/93bab7ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Florence

[](https://www.expedia.com/Florence-Hotels-Charming-3-Bedroom.h123127484.Hotel-Information)

8.8/10

Excellent

(3 reviews)

"Convenient location"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Bonney W.

$457 nightly

$512 total

Mar 1 - Mar 2

Total with taxes and fees

[](https://www.expedia.com/Florence-Hotels-Charming-3-Bedroom.h123127484.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/e85ce030.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/78ec87e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/f2cc1121.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, iron/ironing board, travel crib, WiFi](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/de384ec0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Florence

[](https://www.expedia.com/Florence-Hotels-Take-A-Rest-In-Florence-Ideal-For-I95-Traveler-And-Florence-Center-And-Buc-Ees.h103861731.Hotel-Information)

10/10

Exceptional

(46 reviews)

"I would definitely stay again! Great location."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

LaDara D.

$229 nightly

$257 total

Feb 26 - Feb 27

Total with taxes and fees

[](https://www.expedia.com/Florence-Hotels-Take-A-Rest-In-Florence-Ideal-For-I95-Traveler-And-Florence-Center-And-Buc-Ees.h103861731.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.com/Hotel-Search?startDate=2026-03-11&endDate=2026-03-12&regionId=553248635975849973&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true)

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## 

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## Find vacation rentals that suit your style

Cabins

[](https://www.expedia.com/Hotel-Search?destination=Effingham%2C+South+Carolina%2C+United+States+of+America&regionId=553248635975849973&latLong=34.057571%2C-79.75341&adults=2&startDate=2026-05-25&d1=2026-05-25&endDate=2026-05-28&d2=2026-05-28&lodging=CABIN)

Private vacation homes

[](https://www.expedia.com/Hotel-Search?destination=Effingham%2C+South+Carolina%2C+United+States+of+America&regionId=553248635975849973&latLong=34.057571%2C-79.75341&adults=2&startDate=2026-05-25&d1=2026-05-25&endDate=2026-05-28&d2=2026-05-28&lodging=VACATION_HOME)

Cottages

[](https://www.expedia.com/Hotel-Search?destination=Effingham%2C+South+Carolina%2C+United+States+of+America&regionId=553248635975849973&latLong=34.057571%2C-79.75341&adults=2&startDate=2026-05-25&d1=2026-05-25&endDate=2026-05-28&d2=2026-05-28&lodging=COTTAGE)

Apartments

[](https://www.expedia.com/Hotel-Search?destination=Effingham%2C+South+Carolina%2C+United+States+of+America&regionId=553248635975849973&latLong=34.057571%2C-79.75341&adults=2&startDate=2026-05-25&d1=2026-05-25&endDate=2026-05-28&d2=2026-05-28&lodging=APARTMENT)

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## Top Effingham Hotel Reviews

![Hyatt Place Florence Downtown](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/c29c3321_y.jpg)

### Hyatt Place Florence Downtown

10/10 Excellent

"All was very good"

[](https://expedia.com/Florence-Hotels-Hyatt-Place-Florence-Downtown.h32772870.Hotel-Information)

![Quality Inn & Suites Florence Civic Center](https://images.trvl-media.com/lodging/1000000/20000/11600/11535/74f401dc_y.jpg)

### Quality Inn & Suites Florence Civic Center

10/10 Excellent

"Room was clean, staff very accommodating, breakfast was good. "

[](https://expedia.com/Florence-Hotels-Quality-Inn-And-Suites-Civic.h11535.Hotel-Information)

![Hampton Inn & Suites Florence Center](https://images.trvl-media.com/lodging/1000000/50000/42900/42876/e1b59003_y.jpg)

### Hampton Inn & Suites Florence Center

10/10 Excellent

"Staff was amazing, and rooms where so nice!"

[](https://expedia.com/Florence-Hotels-Hampton-Inn-Suites-Florence-Center.h42876.Hotel-Information)

![Hampton Inn & Suites Florence-North-I-95](https://images.trvl-media.com/lodging/3000000/2400000/2393000/2392993/36a85f8e_y.jpg)

### Hampton Inn & Suites Florence-North-I-95

10/10 Excellent

"Everything was wonderful "

[](https://expedia.com/Florence-Hotels-Hampton-Inn-Suites-Florence-North-I-95.h2392993.Hotel-Information)

![Howard Johnson by Wyndham Florence](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/32fd6fc1_y.jpg)

### Howard Johnson by Wyndham Florence

10/10 Excellent

"Spotless room, friendly staff and great value."

[](https://expedia.com/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information)

![Best Western Inn](https://images.trvl-media.com/lodging/1000000/10000/500/455/344e3fdf_y.jpg)

### Best Western Inn

10/10 Excellent

"It was a pleasure. Everything was great."

[](https://expedia.com/Florence-Hotels-Best-Western-Inn.h455.Hotel-Information)

![Comfort Inn & Suites Florence Center Area](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/a0861bce_y.jpg)

### Comfort Inn & Suites Florence Center Area

10/10 Excellent

"Everyone was friendly, they had the place decorated for Valentine's day, it smelled nice in there as soon as you walked in "

[](https://expedia.com/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information)

![Park Inn by Radisson Florence, SC](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/96d5feb4_y.jpg)

### Park Inn by Radisson Florence, SC

10/10 Excellent

"Clean, safe, pet friendly, nice staff"

[](https://expedia.com/Florence-Hotels-Park-Inn-By-Radisson-Florence.h47086732.Hotel-Information)

![La Quinta Inn & Suites by Wyndham Florence](https://images.trvl-media.com/lodging/1000000/80000/74500/74404/484ca695_y.jpg)

### La Quinta Inn & Suites by Wyndham Florence

10/10 Excellent

"Room was spotless, Staff upon checking in was great. Hotel seemed a bit old we probably needs remodeling at some point. We were there for a quick night on our way to Florida. It was perfect for what we needed. "

[](https://expedia.com/Florence-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Florence.h74404.Hotel-Information)

## Find out more about Effingham

**Everything you need to know about Effingham vacation rentals**

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Effingham vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Effingham vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

**Effingham vacation rentals: An excellent choice for every season**

Whenever you want to travel, a warm welcome awaits you in Effingham. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Effingham in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $196 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

**How to find incredible deals on Effingham rentals**

At Expedia, we put the best Effingham vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Effingham rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Effingham vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Effingham. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

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- [Vacation Homes in Effingham ](https://expedia.com/Effingham-Private-Vacation-Homes.d553248635975849973-aaPrivateVacationHomes.Travel-Guide-Accommodation)
- [Motels in Effingham ](https://expedia.com/Effingham-Motels.d553248635975849973-aaMotels.Travel-Guide-Accommodation)
- [Cottages in Effingham ](https://expedia.com/Effingham-Cottages.d553248635975849973-aaCottages.Travel-Guide-Accommodation)
- [Apartments in Effingham ](https://expedia.com/Effingham-Apartments.d553248635975849973-aaApartments.Travel-Guide-Accommodation)
- [Cabin Rentals in Effingham ](https://expedia.com/Effingham-Cabins.d553248635975849973-aaCabins.Travel-Guide-Accommodation)
- [Condo Rentals in Effingham ](https://expedia.com/Effingham-Condos.d553248635975849973-aaCondos.Travel-Guide-Accommodation)
- [Farmstay in Effingham ](https://expedia.com/Effingham-Agritourism.d553248635975849973-aaAgritourism.Travel-Guide-Accommodation)
- [B&B in Effingham ](https://expedia.com/Effingham-Bed-And-Breakfast.d553248635975849973-aaBedAndBreakfast.Travel-Guide-Accommodation)

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